S100A8/A9: A Potential New Diagnostic Aid for Acute Appendicitis
Objectives: Diagnosing acute appendicitis is a daunting clinical challenge, as there is no single test that reliably distinguishes acute appendicitis from other etiologies of acute abdominal pain. In this study, the authors examined whether circulating levels of S100A8/A9 could be useful as a marke...
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| Veröffentlicht in: | Academic emergency medicine 2010-03, Vol.17 (3), p.333-336 |
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| creator | Bealer, John F. Colgin, Mark |
| description | Objectives: Diagnosing acute appendicitis is a daunting clinical challenge, as there is no single test that reliably distinguishes acute appendicitis from other etiologies of acute abdominal pain. In this study, the authors examined whether circulating levels of S100A8/A9 could be useful as a marker to aid in the diagnosis of acute appendicitis.
Methods: Plasma samples from emergency department (ED) patients with acute abdominal pain (n = 181) were tested using an immunoassay for S100A8/A9.
Results: The sensitivity and specificity for S100A8/A9 in diagnosing acute appendicitis were estimated to be 93% (95% confidence interval [CI] = 81% to 97%) and 54% (95% CI = 45% to 62%), respectively. Negative predictive value (NPV) was 96% (95% CI = 89% to 99%), and positive predictive value (PPV) was 37% (95% CI = 28% to 47%). Performance characteristics of elevated white blood cell (WBC) count were also estimated: sensitivity 63% (95% CI = 47% to 76%), specificity 67% (95% CI = 59% to 75%), NPV 86% (95% CI = 78% to 91%), and PPV 36% (95% CI = 26% to 47%).
Conclusions: This is the first report exploring the relationship between circulating S100A8/A9 and acute appendicitis and establishes proof of concept for this biomarker as a diagnostic test for acute appendicitis. Further studies are indicated to optimize the use of this biomarker, in conjunction with other established approaches.
ACADEMIC EMERGENCY MEDICINE 2010; 17:333–336 © 2010 by the Society for Academic Emergency Medicine |
| doi_str_mv | 10.1111/j.1553-2712.2010.00663.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733645699</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1975928421</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4453-81e85933f17fc2be2ad323f298202542be79d7a645aa7c6f870e33aaaf6045a23</originalsourceid><addsrcrecordid>eNqNkN1LwzAUxYMobk7_BQm--NTuNlmSRhAsc37A_AD1OWRtKhldO5uWbf-9qZt78Mm85HLu7xwuByEcQRj5N5yHEWM0ICIiIQGvAnBOw_UB6u8Xh34GLgPOOO2hE-fmAMCEFMeoR4AKEDzuo5u3CCCJh4m8wgl-rRpTNlYX-Nms8K3Vn2XlGpvixGY4r2qcpG1jcLJcmjKzqW2sO0VHuS6cOdv9A_RxN3kfPwTTl_vHcTIN0tHIXxRHJmaS0jwSeUpmhuiMEpoTGRMgbOQVITOh-YhpLVKexwIMpVrrnIPXCB2gy23usq6-WuMatbAuNUWhS1O1TglKvZlL6cmLP-S8auvSH6cIgZgRJoWH4i2U1pVztcnVsrYLXW9UBKrrWM1VV6XqqlRdx-qnY7X21vNdfjtbmGxv_C3VA9dbYGULs_l3sErGkyc_0W9uZ4Yi</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>220852597</pqid></control><display><type>article</type><title>S100A8/A9: A Potential New Diagnostic Aid for Acute Appendicitis</title><source>MEDLINE</source><source>Wiley Online Library Journals</source><source>Wiley Online Library Free Content</source><source>EZB Electronic Journals Library</source><creator>Bealer, John F. ; Colgin, Mark</creator><creatorcontrib>Bealer, John F. ; Colgin, Mark</creatorcontrib><description>Objectives: Diagnosing acute appendicitis is a daunting clinical challenge, as there is no single test that reliably distinguishes acute appendicitis from other etiologies of acute abdominal pain. In this study, the authors examined whether circulating levels of S100A8/A9 could be useful as a marker to aid in the diagnosis of acute appendicitis.
Methods: Plasma samples from emergency department (ED) patients with acute abdominal pain (n = 181) were tested using an immunoassay for S100A8/A9.
Results: The sensitivity and specificity for S100A8/A9 in diagnosing acute appendicitis were estimated to be 93% (95% confidence interval [CI] = 81% to 97%) and 54% (95% CI = 45% to 62%), respectively. Negative predictive value (NPV) was 96% (95% CI = 89% to 99%), and positive predictive value (PPV) was 37% (95% CI = 28% to 47%). Performance characteristics of elevated white blood cell (WBC) count were also estimated: sensitivity 63% (95% CI = 47% to 76%), specificity 67% (95% CI = 59% to 75%), NPV 86% (95% CI = 78% to 91%), and PPV 36% (95% CI = 26% to 47%).
Conclusions: This is the first report exploring the relationship between circulating S100A8/A9 and acute appendicitis and establishes proof of concept for this biomarker as a diagnostic test for acute appendicitis. Further studies are indicated to optimize the use of this biomarker, in conjunction with other established approaches.
ACADEMIC EMERGENCY MEDICINE 2010; 17:333–336 © 2010 by the Society for Academic Emergency Medicine</description><identifier>ISSN: 1069-6563</identifier><identifier>EISSN: 1553-2712</identifier><identifier>DOI: 10.1111/j.1553-2712.2010.00663.x</identifier><identifier>PMID: 20370768</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Abdomen, Acute - blood ; Abdomen, Acute - diagnosis ; Abdomen, Acute - etiology ; Acute Disease ; Adolescent ; Adult ; Aged ; Appendicitis ; Appendicitis - blood ; Appendicitis - diagnosis ; Appendicitis - epidemiology ; Appendicitis - immunology ; Biomarkers ; Biomarkers - blood ; Calgranulin A - blood ; Calgranulin B - blood ; calprotectin ; Child ; diagnosis ; Diagnosis, Differential ; Emergency Treatment - methods ; Female ; Humans ; Immunoassay ; Leukocyte Count ; Male ; Mass Screening - methods ; Medical diagnosis ; Middle Aged ; Pilot Projects ; Predictive Value of Tests ; Prospective Studies ; ROC Curve ; S100A8/A9 ; Sensitivity and Specificity ; Studies</subject><ispartof>Academic emergency medicine, 2010-03, Vol.17 (3), p.333-336</ispartof><rights>2010 by the Society for Academic Emergency Medicine</rights><rights>Copyright (c) 2010 by the Society for Academic Emergency Medicine.</rights><rights>Copyright Hanley & Belfus, Inc. Mar 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4453-81e85933f17fc2be2ad323f298202542be79d7a645aa7c6f870e33aaaf6045a23</citedby><cites>FETCH-LOGICAL-c4453-81e85933f17fc2be2ad323f298202542be79d7a645aa7c6f870e33aaaf6045a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1553-2712.2010.00663.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1553-2712.2010.00663.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20370768$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bealer, John F.</creatorcontrib><creatorcontrib>Colgin, Mark</creatorcontrib><title>S100A8/A9: A Potential New Diagnostic Aid for Acute Appendicitis</title><title>Academic emergency medicine</title><addtitle>Acad Emerg Med</addtitle><description>Objectives: Diagnosing acute appendicitis is a daunting clinical challenge, as there is no single test that reliably distinguishes acute appendicitis from other etiologies of acute abdominal pain. In this study, the authors examined whether circulating levels of S100A8/A9 could be useful as a marker to aid in the diagnosis of acute appendicitis.
Methods: Plasma samples from emergency department (ED) patients with acute abdominal pain (n = 181) were tested using an immunoassay for S100A8/A9.
Results: The sensitivity and specificity for S100A8/A9 in diagnosing acute appendicitis were estimated to be 93% (95% confidence interval [CI] = 81% to 97%) and 54% (95% CI = 45% to 62%), respectively. Negative predictive value (NPV) was 96% (95% CI = 89% to 99%), and positive predictive value (PPV) was 37% (95% CI = 28% to 47%). Performance characteristics of elevated white blood cell (WBC) count were also estimated: sensitivity 63% (95% CI = 47% to 76%), specificity 67% (95% CI = 59% to 75%), NPV 86% (95% CI = 78% to 91%), and PPV 36% (95% CI = 26% to 47%).
Conclusions: This is the first report exploring the relationship between circulating S100A8/A9 and acute appendicitis and establishes proof of concept for this biomarker as a diagnostic test for acute appendicitis. Further studies are indicated to optimize the use of this biomarker, in conjunction with other established approaches.
ACADEMIC EMERGENCY MEDICINE 2010; 17:333–336 © 2010 by the Society for Academic Emergency Medicine</description><subject>Abdomen, Acute - blood</subject><subject>Abdomen, Acute - diagnosis</subject><subject>Abdomen, Acute - etiology</subject><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Appendicitis</subject><subject>Appendicitis - blood</subject><subject>Appendicitis - diagnosis</subject><subject>Appendicitis - epidemiology</subject><subject>Appendicitis - immunology</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Calgranulin A - blood</subject><subject>Calgranulin B - blood</subject><subject>calprotectin</subject><subject>Child</subject><subject>diagnosis</subject><subject>Diagnosis, Differential</subject><subject>Emergency Treatment - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Mass Screening - methods</subject><subject>Medical diagnosis</subject><subject>Middle Aged</subject><subject>Pilot Projects</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>ROC Curve</subject><subject>S100A8/A9</subject><subject>Sensitivity and Specificity</subject><subject>Studies</subject><issn>1069-6563</issn><issn>1553-2712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkN1LwzAUxYMobk7_BQm--NTuNlmSRhAsc37A_AD1OWRtKhldO5uWbf-9qZt78Mm85HLu7xwuByEcQRj5N5yHEWM0ICIiIQGvAnBOw_UB6u8Xh34GLgPOOO2hE-fmAMCEFMeoR4AKEDzuo5u3CCCJh4m8wgl-rRpTNlYX-Nms8K3Vn2XlGpvixGY4r2qcpG1jcLJcmjKzqW2sO0VHuS6cOdv9A_RxN3kfPwTTl_vHcTIN0tHIXxRHJmaS0jwSeUpmhuiMEpoTGRMgbOQVITOh-YhpLVKexwIMpVrrnIPXCB2gy23usq6-WuMatbAuNUWhS1O1TglKvZlL6cmLP-S8auvSH6cIgZgRJoWH4i2U1pVztcnVsrYLXW9UBKrrWM1VV6XqqlRdx-qnY7X21vNdfjtbmGxv_C3VA9dbYGULs_l3sErGkyc_0W9uZ4Yi</recordid><startdate>201003</startdate><enddate>201003</enddate><creator>Bealer, John F.</creator><creator>Colgin, Mark</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>201003</creationdate><title>S100A8/A9: A Potential New Diagnostic Aid for Acute Appendicitis</title><author>Bealer, John F. ; Colgin, Mark</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4453-81e85933f17fc2be2ad323f298202542be79d7a645aa7c6f870e33aaaf6045a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Abdomen, Acute - blood</topic><topic>Abdomen, Acute - diagnosis</topic><topic>Abdomen, Acute - etiology</topic><topic>Acute Disease</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Appendicitis</topic><topic>Appendicitis - blood</topic><topic>Appendicitis - diagnosis</topic><topic>Appendicitis - epidemiology</topic><topic>Appendicitis - immunology</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Calgranulin A - blood</topic><topic>Calgranulin B - blood</topic><topic>calprotectin</topic><topic>Child</topic><topic>diagnosis</topic><topic>Diagnosis, Differential</topic><topic>Emergency Treatment - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Mass Screening - methods</topic><topic>Medical diagnosis</topic><topic>Middle Aged</topic><topic>Pilot Projects</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>ROC Curve</topic><topic>S100A8/A9</topic><topic>Sensitivity and Specificity</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bealer, John F.</creatorcontrib><creatorcontrib>Colgin, Mark</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Academic emergency medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bealer, John F.</au><au>Colgin, Mark</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>S100A8/A9: A Potential New Diagnostic Aid for Acute Appendicitis</atitle><jtitle>Academic emergency medicine</jtitle><addtitle>Acad Emerg Med</addtitle><date>2010-03</date><risdate>2010</risdate><volume>17</volume><issue>3</issue><spage>333</spage><epage>336</epage><pages>333-336</pages><issn>1069-6563</issn><eissn>1553-2712</eissn><abstract>Objectives: Diagnosing acute appendicitis is a daunting clinical challenge, as there is no single test that reliably distinguishes acute appendicitis from other etiologies of acute abdominal pain. In this study, the authors examined whether circulating levels of S100A8/A9 could be useful as a marker to aid in the diagnosis of acute appendicitis.
Methods: Plasma samples from emergency department (ED) patients with acute abdominal pain (n = 181) were tested using an immunoassay for S100A8/A9.
Results: The sensitivity and specificity for S100A8/A9 in diagnosing acute appendicitis were estimated to be 93% (95% confidence interval [CI] = 81% to 97%) and 54% (95% CI = 45% to 62%), respectively. Negative predictive value (NPV) was 96% (95% CI = 89% to 99%), and positive predictive value (PPV) was 37% (95% CI = 28% to 47%). Performance characteristics of elevated white blood cell (WBC) count were also estimated: sensitivity 63% (95% CI = 47% to 76%), specificity 67% (95% CI = 59% to 75%), NPV 86% (95% CI = 78% to 91%), and PPV 36% (95% CI = 26% to 47%).
Conclusions: This is the first report exploring the relationship between circulating S100A8/A9 and acute appendicitis and establishes proof of concept for this biomarker as a diagnostic test for acute appendicitis. Further studies are indicated to optimize the use of this biomarker, in conjunction with other established approaches.
ACADEMIC EMERGENCY MEDICINE 2010; 17:333–336 © 2010 by the Society for Academic Emergency Medicine</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20370768</pmid><doi>10.1111/j.1553-2712.2010.00663.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Abdomen, Acute - blood Abdomen, Acute - diagnosis Abdomen, Acute - etiology Acute Disease Adolescent Adult Aged Appendicitis Appendicitis - blood Appendicitis - diagnosis Appendicitis - epidemiology Appendicitis - immunology Biomarkers Biomarkers - blood Calgranulin A - blood Calgranulin B - blood calprotectin Child diagnosis Diagnosis, Differential Emergency Treatment - methods Female Humans Immunoassay Leukocyte Count Male Mass Screening - methods Medical diagnosis Middle Aged Pilot Projects Predictive Value of Tests Prospective Studies ROC Curve S100A8/A9 Sensitivity and Specificity Studies |
| title | S100A8/A9: A Potential New Diagnostic Aid for Acute Appendicitis |
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