Body weight and fat-free mass changes in a cohort of patients receiving chemotherapy
Purpose Malnutrition is prevalent in cancer patients and it can become even greater during its treatment. The purpose of the present study is to verify changes in the fat-free mass (FFM) and body weight (BW) in cancer patients during chemotherapy treatment and to identify their significant determina...
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| Veröffentlicht in: | Supportive care in cancer 2010-05, Vol.18 (5), p.617-625 |
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| container_title | Supportive care in cancer |
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| creator | Halpern-Silveira, Denise Susin, Lulie Rosane O. Borges, Lúcia R. Paiva, Silvana I. Assunção, Maria Cecília F. Gonzalez, Maria Cristina |
| description | Purpose
Malnutrition is prevalent in cancer patients and it can become even greater during its treatment. The purpose of the present study is to verify changes in the fat-free mass (FFM) and body weight (BW) in cancer patients during chemotherapy treatment and to identify their significant determinants.
Methods
In a longitudinal study of 174 patients starting a chemotherapy protocol, bioelectrical impedance analysis (BIA) was used to estimate FFM and the nutritional assessment by patient-generated subjective global assessment. BW and FFM changes have been calculated and their significant determinants were identified after a multivariate analysis.
Results
Malnutrition was found in 23% of the patients at the admission. After a multivariate analysis, a significant BW change was found during the treatment in patients submitted to previous/adjuvant and palliative chemotherapy (weight gain of 4.15% and 2.23%, respectively,
p
= 0.05) and a significant FFM loss (7.61%,
p
|
| doi_str_mv | 10.1007/s00520-009-0703-6 |
| format | Article |
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Malnutrition is prevalent in cancer patients and it can become even greater during its treatment. The purpose of the present study is to verify changes in the fat-free mass (FFM) and body weight (BW) in cancer patients during chemotherapy treatment and to identify their significant determinants.
Methods
In a longitudinal study of 174 patients starting a chemotherapy protocol, bioelectrical impedance analysis (BIA) was used to estimate FFM and the nutritional assessment by patient-generated subjective global assessment. BW and FFM changes have been calculated and their significant determinants were identified after a multivariate analysis.
Results
Malnutrition was found in 23% of the patients at the admission. After a multivariate analysis, a significant BW change was found during the treatment in patients submitted to previous/adjuvant and palliative chemotherapy (weight gain of 4.15% and 2.23%, respectively,
p
= 0.05) and a significant FFM loss (7.61%,
p
< 0.01) in patients with severe malnutrition at admission.
Conclusions
Only the chemotherapy protocol and initial nutritional state had a significant influence in BW and FFM changes during the chemotherapy. BIA may contribute to other methods of nutritional assessment, in order to detect modifications in body composition even in the absence of BW changes.</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-009-0703-6</identifier><identifier>PMID: 19621246</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adolescent ; Adult ; Analysis ; Antineoplastic Agents - therapeutic use ; Body fat ; Body Weight ; Brazil ; Cancer ; Cancer patients ; Care and treatment ; Changes ; Chemotherapy ; Child ; Cohort Studies ; Female ; Humans ; Male ; Malnutrition ; Malnutrition - etiology ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasms - drug therapy ; Nursing ; Nursing Research ; Nutrition ; Nutrition Assessment ; Nutritional Status ; Oncology ; Original Article ; Pain Medicine ; Physiological aspects ; Product/Service Evaluations ; Prospective Studies ; Rehabilitation Medicine ; Thinness - etiology ; Weight ; Young Adult</subject><ispartof>Supportive care in cancer, 2010-05, Vol.18 (5), p.617-625</ispartof><rights>Springer-Verlag 2009</rights><rights>COPYRIGHT 2010 Springer</rights><rights>Springer-Verlag 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-b6adadce5001f9d6027e4d6b510db7416fc533ff0b538307fd8319a0a646cf7a3</citedby><cites>FETCH-LOGICAL-c503t-b6adadce5001f9d6027e4d6b510db7416fc533ff0b538307fd8319a0a646cf7a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-009-0703-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-009-0703-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19621246$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Halpern-Silveira, Denise</creatorcontrib><creatorcontrib>Susin, Lulie Rosane O.</creatorcontrib><creatorcontrib>Borges, Lúcia R.</creatorcontrib><creatorcontrib>Paiva, Silvana I.</creatorcontrib><creatorcontrib>Assunção, Maria Cecília F.</creatorcontrib><creatorcontrib>Gonzalez, Maria Cristina</creatorcontrib><title>Body weight and fat-free mass changes in a cohort of patients receiving chemotherapy</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Purpose
Malnutrition is prevalent in cancer patients and it can become even greater during its treatment. The purpose of the present study is to verify changes in the fat-free mass (FFM) and body weight (BW) in cancer patients during chemotherapy treatment and to identify their significant determinants.
Methods
In a longitudinal study of 174 patients starting a chemotherapy protocol, bioelectrical impedance analysis (BIA) was used to estimate FFM and the nutritional assessment by patient-generated subjective global assessment. BW and FFM changes have been calculated and their significant determinants were identified after a multivariate analysis.
Results
Malnutrition was found in 23% of the patients at the admission. After a multivariate analysis, a significant BW change was found during the treatment in patients submitted to previous/adjuvant and palliative chemotherapy (weight gain of 4.15% and 2.23%, respectively,
p
= 0.05) and a significant FFM loss (7.61%,
p
< 0.01) in patients with severe malnutrition at admission.
Conclusions
Only the chemotherapy protocol and initial nutritional state had a significant influence in BW and FFM changes during the chemotherapy. BIA may contribute to other methods of nutritional assessment, in order to detect modifications in body composition even in the absence of BW changes.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Analysis</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Body fat</subject><subject>Body Weight</subject><subject>Brazil</subject><subject>Cancer</subject><subject>Cancer patients</subject><subject>Care and treatment</subject><subject>Changes</subject><subject>Chemotherapy</subject><subject>Child</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Malnutrition</subject><subject>Malnutrition - etiology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasms - drug therapy</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Nutrition</subject><subject>Nutrition Assessment</subject><subject>Nutritional Status</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pain Medicine</subject><subject>Physiological aspects</subject><subject>Product/Service Evaluations</subject><subject>Prospective Studies</subject><subject>Rehabilitation Medicine</subject><subject>Thinness - etiology</subject><subject>Weight</subject><subject>Young Adult</subject><issn>0941-4355</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kc2KFDEUhYMoTjv6AG4k6MJVxpvKX9dyHPyDATfjOqSSm-4MXZU2qR7ptzdNNQyKkkUg-c7lJB8hrzlccQDzoQKoDhhAz8CAYPoJWXEpBDNC9E_JCnrJmRRKXZAXtd4DcGNU95xc8F53vJN6Re4-5nCkvzBttjN1U6DRzSwWRDq6WqnfummDlaaJOurzNpeZ5kj3bk44zZUW9Jge0rRpJI553mJx--NL8iy6XcVX5_2S_Pj86e7mK7v9_uXbzfUt8wrEzAbtggseVSsW-6ChMyiDHhSHMBjJdfRKiBhhUGItwMSwFrx34LTUPhonLsn7Ze6-5J8HrLMdU_W427kJ86Ha9g1aSqVUI9_-Rd7nQ5laObvWvVSa932D3i3Qxu3QpinmuTh_GmmvhTJrLQWHRl39g2or4Jh8njCmdv5HgC8BX3KtBaPdlzS6crQc7MmjXTza5tGePFrdMm_OfQ_DiOExcRbXgG4Bartqisrjg_4_9TeAKaXN</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>Halpern-Silveira, Denise</creator><creator>Susin, Lulie Rosane O.</creator><creator>Borges, Lúcia R.</creator><creator>Paiva, Silvana I.</creator><creator>Assunção, Maria Cecília F.</creator><creator>Gonzalez, Maria Cristina</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M2S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20100501</creationdate><title>Body weight and fat-free mass changes in a cohort of patients receiving chemotherapy</title><author>Halpern-Silveira, Denise ; Susin, Lulie Rosane O. ; Borges, Lúcia R. ; Paiva, Silvana I. ; Assunção, Maria Cecília F. ; Gonzalez, Maria Cristina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-b6adadce5001f9d6027e4d6b510db7416fc533ff0b538307fd8319a0a646cf7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Analysis</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Body fat</topic><topic>Body Weight</topic><topic>Brazil</topic><topic>Cancer</topic><topic>Cancer patients</topic><topic>Care and treatment</topic><topic>Changes</topic><topic>Chemotherapy</topic><topic>Child</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Malnutrition</topic><topic>Malnutrition - etiology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasms - drug therapy</topic><topic>Nursing</topic><topic>Nursing Research</topic><topic>Nutrition</topic><topic>Nutrition Assessment</topic><topic>Nutritional Status</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pain Medicine</topic><topic>Physiological aspects</topic><topic>Product/Service Evaluations</topic><topic>Prospective Studies</topic><topic>Rehabilitation Medicine</topic><topic>Thinness - etiology</topic><topic>Weight</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Halpern-Silveira, Denise</creatorcontrib><creatorcontrib>Susin, Lulie Rosane O.</creatorcontrib><creatorcontrib>Borges, Lúcia R.</creatorcontrib><creatorcontrib>Paiva, Silvana I.</creatorcontrib><creatorcontrib>Assunção, Maria Cecília F.</creatorcontrib><creatorcontrib>Gonzalez, Maria Cristina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Supportive care in cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Halpern-Silveira, Denise</au><au>Susin, Lulie Rosane O.</au><au>Borges, Lúcia R.</au><au>Paiva, Silvana I.</au><au>Assunção, Maria Cecília F.</au><au>Gonzalez, Maria Cristina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Body weight and fat-free mass changes in a cohort of patients receiving chemotherapy</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>18</volume><issue>5</issue><spage>617</spage><epage>625</epage><pages>617-625</pages><issn>0941-4355</issn><eissn>1433-7339</eissn><abstract>Purpose
Malnutrition is prevalent in cancer patients and it can become even greater during its treatment. The purpose of the present study is to verify changes in the fat-free mass (FFM) and body weight (BW) in cancer patients during chemotherapy treatment and to identify their significant determinants.
Methods
In a longitudinal study of 174 patients starting a chemotherapy protocol, bioelectrical impedance analysis (BIA) was used to estimate FFM and the nutritional assessment by patient-generated subjective global assessment. BW and FFM changes have been calculated and their significant determinants were identified after a multivariate analysis.
Results
Malnutrition was found in 23% of the patients at the admission. After a multivariate analysis, a significant BW change was found during the treatment in patients submitted to previous/adjuvant and palliative chemotherapy (weight gain of 4.15% and 2.23%, respectively,
p
= 0.05) and a significant FFM loss (7.61%,
p
< 0.01) in patients with severe malnutrition at admission.
Conclusions
Only the chemotherapy protocol and initial nutritional state had a significant influence in BW and FFM changes during the chemotherapy. BIA may contribute to other methods of nutritional assessment, in order to detect modifications in body composition even in the absence of BW changes.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>19621246</pmid><doi>10.1007/s00520-009-0703-6</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0941-4355 |
| ispartof | Supportive care in cancer, 2010-05, Vol.18 (5), p.617-625 |
| issn | 0941-4355 1433-7339 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Adult Analysis Antineoplastic Agents - therapeutic use Body fat Body Weight Brazil Cancer Cancer patients Care and treatment Changes Chemotherapy Child Cohort Studies Female Humans Male Malnutrition Malnutrition - etiology Medicine Medicine & Public Health Middle Aged Neoplasms - drug therapy Nursing Nursing Research Nutrition Nutrition Assessment Nutritional Status Oncology Original Article Pain Medicine Physiological aspects Product/Service Evaluations Prospective Studies Rehabilitation Medicine Thinness - etiology Weight Young Adult |
| title | Body weight and fat-free mass changes in a cohort of patients receiving chemotherapy |
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