Performance- and safety-enhanced lentiviral vectors containing the human interferon-β scaffold attachment region and the chicken β-globin insulator

Retroviral vectors are the most efficient means of stable gene delivery to hematopoietic stem cells (HSCs). However, transgene expression from retroviral vectors is frequently subject to the negative influence of chromosomal sequences flanking the site of integration. Toward the development of auton...

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Veröffentlicht in:	Blood 2003-06, Vol.101 (12), p.4717-4724
Hauptverfasser:	Ramezani, Ali, Hawley, Teresa S., Hawley, Robert G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Antigens, CD34 - analysis Applied cell therapy and gene therapy Binding Sites Biological and medical sciences Blotting, Southern Cell Differentiation Cell Line Cells, Cultured Chickens DNA - analysis Erythroid-Specific DNA-Binding Factors Fetal Blood - cytology Gene Expression Genetic Vectors - therapeutic use Globins - genetics Green Fluorescent Proteins Hematopoietic Stem Cells - immunology Hematopoietic Stem Cells - metabolism Humans Insulator Elements - genetics Interferon-beta - genetics Lentivirus - genetics Luminescent Proteins - genetics Medical sciences Monocytes - metabolism Nuclear Matrix-Associated Proteins - genetics Nuclear Matrix-Associated Proteins - metabolism Peptide Elongation Factor 1 - genetics Promoter Regions, Genetic Terminal Repeat Sequences Transcription Factors - genetics Transfection Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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