Two Cases of Corneal Perforation after Oral Administration of Nonsteroidal Anti-Inflammatory Drugs: Oral Nsaid-Induced Corneal Damage
Purpose. To report 2 cases of corneal perforation associated with the use of oral nonsteroidal anti-inflammatory drugs (NSAIDs). Methods. In a 62-year-old woman and a 79-year-old woman, corneal perforation occurred after 7 days and 5 months of oral NSAIDs administration, respectively. Results. After...
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| Veröffentlicht in: | European journal of ophthalmology 2010-03, Vol.20 (2), p.454-456 |
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| container_title | European journal of ophthalmology |
| container_volume | 20 |
| creator | Masuda, Ikuya Matsuo, Toshihiko Okamoto, Kazuo Matsushita, Kyoko Ohtsuki, Hiroshi |
| description | Purpose.
To report 2 cases of corneal perforation associated with the use of oral nonsteroidal anti-inflammatory drugs (NSAIDs).
Methods.
In a 62-year-old woman and a 79-year-old woman, corneal perforation occurred after 7 days and 5 months of oral NSAIDs administration, respectively.
Results.
After NSAIDs were discontinued, the cornea epithelialized and the anterior chamber formed within 14 and 10 days, respectively.
Conclusions.
It is well known that topical NSAIDs cause corneal perforation. Observations in the present cases suggest that the oral administration of NSAIDs may also cause corneal damage, and hence, medical professionals should consider the risk of damage to the cornea when administering these drugs orally. |
| doi_str_mv | 10.1177/112067211002000230 |
| format | Article |
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To report 2 cases of corneal perforation associated with the use of oral nonsteroidal anti-inflammatory drugs (NSAIDs).
Methods.
In a 62-year-old woman and a 79-year-old woman, corneal perforation occurred after 7 days and 5 months of oral NSAIDs administration, respectively.
Results.
After NSAIDs were discontinued, the cornea epithelialized and the anterior chamber formed within 14 and 10 days, respectively.
Conclusions.
It is well known that topical NSAIDs cause corneal perforation. Observations in the present cases suggest that the oral administration of NSAIDs may also cause corneal damage, and hence, medical professionals should consider the risk of damage to the cornea when administering these drugs orally.</description><identifier>ISSN: 1120-6721</identifier><identifier>EISSN: 1724-6016</identifier><identifier>DOI: 10.1177/112067211002000230</identifier><identifier>PMID: 20037896</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Administration, Oral ; Aged ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal - adverse effects ; Arthritis, Rheumatoid - drug therapy ; Cornea - drug effects ; Cornea - pathology ; Corneal Perforation - chemically induced ; Corneal Perforation - pathology ; Female ; Follow-Up Studies ; Humans ; Middle Aged ; Mixed Connective Tissue Disease - drug therapy ; Wound Healing</subject><ispartof>European journal of ophthalmology, 2010-03, Vol.20 (2), p.454-456</ispartof><rights>2010 SAGE Publications</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-e5627af03410b81593bf66a0bc2e8c096d3f7a49fc6c1a9b14492850ab2d825f3</citedby><cites>FETCH-LOGICAL-c342t-e5627af03410b81593bf66a0bc2e8c096d3f7a49fc6c1a9b14492850ab2d825f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/112067211002000230$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/112067211002000230$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21818,27923,27924,43620,43621</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20037896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Masuda, Ikuya</creatorcontrib><creatorcontrib>Matsuo, Toshihiko</creatorcontrib><creatorcontrib>Okamoto, Kazuo</creatorcontrib><creatorcontrib>Matsushita, Kyoko</creatorcontrib><creatorcontrib>Ohtsuki, Hiroshi</creatorcontrib><title>Two Cases of Corneal Perforation after Oral Administration of Nonsteroidal Anti-Inflammatory Drugs: Oral Nsaid-Induced Corneal Damage</title><title>European journal of ophthalmology</title><addtitle>Eur J Ophthalmol</addtitle><description>Purpose.
To report 2 cases of corneal perforation associated with the use of oral nonsteroidal anti-inflammatory drugs (NSAIDs).
Methods.
In a 62-year-old woman and a 79-year-old woman, corneal perforation occurred after 7 days and 5 months of oral NSAIDs administration, respectively.
Results.
After NSAIDs were discontinued, the cornea epithelialized and the anterior chamber formed within 14 and 10 days, respectively.
Conclusions.
It is well known that topical NSAIDs cause corneal perforation. Observations in the present cases suggest that the oral administration of NSAIDs may also cause corneal damage, and hence, medical professionals should consider the risk of damage to the cornea when administering these drugs orally.</description><subject>Administration, Oral</subject><subject>Aged</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - adverse effects</subject><subject>Arthritis, Rheumatoid - drug therapy</subject><subject>Cornea - drug effects</subject><subject>Cornea - pathology</subject><subject>Corneal Perforation - chemically induced</subject><subject>Corneal Perforation - pathology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Mixed Connective Tissue Disease - drug therapy</subject><subject>Wound Healing</subject><issn>1120-6721</issn><issn>1724-6016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAURC0EoqXwAyxQdqxC_UichF3V8qhUtSzKOrrxo0qVxMVOhPoB_DeOUtggsbBsec7M1R2Ebgl-ICRJpoRQzBNKCMYU-8PwGRqThEYhx4Sf-7cHwp4YoSvn9j2WRfQSjTzOkjTjY_S1_TTBHJxygdHB3NhGQRW8KauNhbY0TQC6VTbYWP89k3XZlK49Kd6wNo3zsillLzdtGS4bXUFdQ2vsMVjYbuceB_PaQSm9LDuh5O-kBdSwU9foQkPl1M3pnqD356ft_DVcbV6W89kqFCyibahiThPQmEUEFymJM1ZozgEXgqpU4IxLphOIMi24IJAVJIoymsYYCipTGms2QfdD7sGaj065Nq9LJ1RVQaNM5_KEMR6xlGSepAMprHHOKp0fbFmDPeYE5337-d_2venuFN8VtZK_lp-6PTAdAOeXzvems41f97_IbzvRjSQ</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Masuda, Ikuya</creator><creator>Matsuo, Toshihiko</creator><creator>Okamoto, Kazuo</creator><creator>Matsushita, Kyoko</creator><creator>Ohtsuki, Hiroshi</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100301</creationdate><title>Two Cases of Corneal Perforation after Oral Administration of Nonsteroidal Anti-Inflammatory Drugs: Oral Nsaid-Induced Corneal Damage</title><author>Masuda, Ikuya ; Matsuo, Toshihiko ; Okamoto, Kazuo ; Matsushita, Kyoko ; Ohtsuki, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-e5627af03410b81593bf66a0bc2e8c096d3f7a49fc6c1a9b14492850ab2d825f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Administration, Oral</topic><topic>Aged</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - adverse effects</topic><topic>Arthritis, Rheumatoid - drug therapy</topic><topic>Cornea - drug effects</topic><topic>Cornea - pathology</topic><topic>Corneal Perforation - chemically induced</topic><topic>Corneal Perforation - pathology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Mixed Connective Tissue Disease - drug therapy</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Masuda, Ikuya</creatorcontrib><creatorcontrib>Matsuo, Toshihiko</creatorcontrib><creatorcontrib>Okamoto, Kazuo</creatorcontrib><creatorcontrib>Matsushita, Kyoko</creatorcontrib><creatorcontrib>Ohtsuki, Hiroshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Masuda, Ikuya</au><au>Matsuo, Toshihiko</au><au>Okamoto, Kazuo</au><au>Matsushita, Kyoko</au><au>Ohtsuki, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two Cases of Corneal Perforation after Oral Administration of Nonsteroidal Anti-Inflammatory Drugs: Oral Nsaid-Induced Corneal Damage</atitle><jtitle>European journal of ophthalmology</jtitle><addtitle>Eur J Ophthalmol</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>20</volume><issue>2</issue><spage>454</spage><epage>456</epage><pages>454-456</pages><issn>1120-6721</issn><eissn>1724-6016</eissn><abstract>Purpose.
To report 2 cases of corneal perforation associated with the use of oral nonsteroidal anti-inflammatory drugs (NSAIDs).
Methods.
In a 62-year-old woman and a 79-year-old woman, corneal perforation occurred after 7 days and 5 months of oral NSAIDs administration, respectively.
Results.
After NSAIDs were discontinued, the cornea epithelialized and the anterior chamber formed within 14 and 10 days, respectively.
Conclusions.
It is well known that topical NSAIDs cause corneal perforation. Observations in the present cases suggest that the oral administration of NSAIDs may also cause corneal damage, and hence, medical professionals should consider the risk of damage to the cornea when administering these drugs orally.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>20037896</pmid><doi>10.1177/112067211002000230</doi><tpages>3</tpages></addata></record> |
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| ispartof | European journal of ophthalmology, 2010-03, Vol.20 (2), p.454-456 |
| issn | 1120-6721 1724-6016 |
| language | eng |
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| source | MEDLINE; SAGE Complete A-Z List |
| subjects | Administration, Oral Aged Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - adverse effects Arthritis, Rheumatoid - drug therapy Cornea - drug effects Cornea - pathology Corneal Perforation - chemically induced Corneal Perforation - pathology Female Follow-Up Studies Humans Middle Aged Mixed Connective Tissue Disease - drug therapy Wound Healing |
| title | Two Cases of Corneal Perforation after Oral Administration of Nonsteroidal Anti-Inflammatory Drugs: Oral Nsaid-Induced Corneal Damage |
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