AT1 Receptor Blockade Improves Vasorelaxation in Experimental Renal Failure

ABSTRACT—It is not known whether angiotensin II type 1 receptor antagonists can influence the function and morphology of small arteries in renal failure. We investigated the effect of 8-week losartan therapy (20 mg/kg per day) on isolated mesenteric resistance arteries by wire and pressure myographs...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2003-06, Vol.41 (6), p.1364-1371
Hauptverfasser:	Kööbi, Peeter, Kalliovalkama, Jarkko, Jolma, Pasi, Rysä, Jaana, Ruskoaho, Heikki, Vuolteenaho, Olli, Kähönen, Mika, Tikkanen, Ilkka, Fan, Meng, Ylitalo, Pauli, Pörsti, Ilkka
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Receptor Antagonists Animals Aorta - chemistry Atrial Natriuretic Factor - biosynthesis Atrial Natriuretic Factor - blood Atrial Natriuretic Factor - genetics Biological and medical sciences Blood Pressure Cardiovascular system Endothelium, Vascular - physiology Heart Ventricles - metabolism In Vitro Techniques Losartan - therapeutic use Male Medical sciences Mesenteric Arteries - drug effects Mesenteric Arteries - pathology Mesenteric Arteries - physiopathology Natriuretic Peptide, Brain - biosynthesis Natriuretic Peptide, Brain - genetics Nephrectomy Peptidyl-Dipeptidase A - analysis Pharmacology. Drug treatments Potassium Channel Blockers - pharmacology Potassium Channels, Calcium-Activated - antagonists & inhibitors Protein Precursors - blood Rats Rats, Sprague-Dawley Receptor, Angiotensin, Type 1 Renal Insufficiency - drug therapy Renal Insufficiency - pathology Renal Insufficiency - physiopathology RNA, Messenger - biosynthesis Vasoconstriction Vasodilation - drug effects Vasodilator agents. Cerebral vasodilators
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