Transcriptional Control of a Plant Stem Cell Niche
Despite the independent evolution of multicellularity in plants and animals, the basic organization of their stem cell niches is remarkably similar. Here, we report the genome-wide regulatory potential of WUSCHEL, the key transcription factor for stem cell maintenance in the shoot apical meristem of...
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| Veröffentlicht in: | Developmental cell 2010-05, Vol.18 (5), p.841-853 |
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| creator | Busch, Wolfgang Miotk, Andrej Ariel, Federico D. Zhao, Zhong Forner, Joachim Daum, Gabor Suzaki, Takuya Schuster, Christoph Schultheiss, Sebastian J. Leibfried, Andrea Haubeiß, Silke Ha, Nati Chan, Raquel L. Lohmann, Jan U. |
| description | Despite the independent evolution of multicellularity in plants and animals, the basic organization of their stem cell niches is remarkably similar. Here, we report the genome-wide regulatory potential of WUSCHEL, the key transcription factor for stem cell maintenance in the shoot apical meristem of the reference plant
Arabidopsis thaliana. WUSCHEL acts by directly binding to at least two distinct DNA motifs in more than 100 target promoters and preferentially affects the expression of genes with roles in hormone signaling, metabolism, and development. Striking examples are the direct transcriptional repression of
CLAVATA1, which is part of a negative feedback regulation of
WUSCHEL, and the immediate regulation of transcriptional repressors of the TOPLESS family, which are involved in auxin signaling. Our results shed light on the complex transcriptional programs required for the maintenance of a dynamic and essential stem cell niche.
[Display omitted]
► WUSCHEL (WUS) regulates genes with roles in metabolism, development, and signaling ► WUS binds to at least two diverse DNA motifs with different affinity ► WUS associates with more than 100 chromatin regions in vivo ► Direct WUS targets include key regulators, such as
CLAVATA1 and
TOPLESS |
| doi_str_mv | 10.1016/j.devcel.2010.03.012 |
| format | Article |
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Arabidopsis thaliana. WUSCHEL acts by directly binding to at least two distinct DNA motifs in more than 100 target promoters and preferentially affects the expression of genes with roles in hormone signaling, metabolism, and development. Striking examples are the direct transcriptional repression of
CLAVATA1, which is part of a negative feedback regulation of
WUSCHEL, and the immediate regulation of transcriptional repressors of the TOPLESS family, which are involved in auxin signaling. Our results shed light on the complex transcriptional programs required for the maintenance of a dynamic and essential stem cell niche.
[Display omitted]
► WUSCHEL (WUS) regulates genes with roles in metabolism, development, and signaling ► WUS binds to at least two diverse DNA motifs with different affinity ► WUS associates with more than 100 chromatin regions in vivo ► Direct WUS targets include key regulators, such as
CLAVATA1 and
TOPLESS</description><identifier>ISSN: 1534-5807</identifier><identifier>EISSN: 1878-1551</identifier><identifier>DOI: 10.1016/j.devcel.2010.03.012</identifier><identifier>PMID: 20493817</identifier><language>eng</language><publisher>Cambridge, MA: Elsevier Inc</publisher><subject>Arabidopsis - genetics ; Arabidopsis - growth & development ; Arabidopsis Proteins - genetics ; Arabidopsis Proteins - physiology ; Biological and medical sciences ; Cell differentiation, maturation, development, hematopoiesis ; Cell physiology ; Chromatin - genetics ; DEVBIO ; DNA-Binding Proteins - genetics ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Plant ; Genome, Plant ; Genome-Wide Association Study ; Homeodomain Proteins - genetics ; Homeodomain Proteins - physiology ; Homeostasis ; Meristem - genetics ; Meristem - physiology ; Molecular and cellular biology ; Molecular genetics ; Plant Stems - physiology ; Protein-Serine-Threonine Kinases ; Receptor Protein-Tyrosine Kinases - genetics ; STEMCELL ; Transcription Factors - genetics ; Transcription, Genetic ; Transcription. Transcription factor. Splicing. Rna processing</subject><ispartof>Developmental cell, 2010-05, Vol.18 (5), p.841-853</ispartof><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-16b020ea47bcba3fdd2f005a2fe5796ca1d726f8aacec3f512220c16c07530e13</citedby><cites>FETCH-LOGICAL-c503t-16b020ea47bcba3fdd2f005a2fe5796ca1d726f8aacec3f512220c16c07530e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1534580710001516$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22833763$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20493817$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Busch, Wolfgang</creatorcontrib><creatorcontrib>Miotk, Andrej</creatorcontrib><creatorcontrib>Ariel, Federico D.</creatorcontrib><creatorcontrib>Zhao, Zhong</creatorcontrib><creatorcontrib>Forner, Joachim</creatorcontrib><creatorcontrib>Daum, Gabor</creatorcontrib><creatorcontrib>Suzaki, Takuya</creatorcontrib><creatorcontrib>Schuster, Christoph</creatorcontrib><creatorcontrib>Schultheiss, Sebastian J.</creatorcontrib><creatorcontrib>Leibfried, Andrea</creatorcontrib><creatorcontrib>Haubeiß, Silke</creatorcontrib><creatorcontrib>Ha, Nati</creatorcontrib><creatorcontrib>Chan, Raquel L.</creatorcontrib><creatorcontrib>Lohmann, Jan U.</creatorcontrib><title>Transcriptional Control of a Plant Stem Cell Niche</title><title>Developmental cell</title><addtitle>Dev Cell</addtitle><description>Despite the independent evolution of multicellularity in plants and animals, the basic organization of their stem cell niches is remarkably similar. Here, we report the genome-wide regulatory potential of WUSCHEL, the key transcription factor for stem cell maintenance in the shoot apical meristem of the reference plant
Arabidopsis thaliana. WUSCHEL acts by directly binding to at least two distinct DNA motifs in more than 100 target promoters and preferentially affects the expression of genes with roles in hormone signaling, metabolism, and development. Striking examples are the direct transcriptional repression of
CLAVATA1, which is part of a negative feedback regulation of
WUSCHEL, and the immediate regulation of transcriptional repressors of the TOPLESS family, which are involved in auxin signaling. Our results shed light on the complex transcriptional programs required for the maintenance of a dynamic and essential stem cell niche.
[Display omitted]
► WUSCHEL (WUS) regulates genes with roles in metabolism, development, and signaling ► WUS binds to at least two diverse DNA motifs with different affinity ► WUS associates with more than 100 chromatin regions in vivo ► Direct WUS targets include key regulators, such as
CLAVATA1 and
TOPLESS</description><subject>Arabidopsis - genetics</subject><subject>Arabidopsis - growth & development</subject><subject>Arabidopsis Proteins - genetics</subject><subject>Arabidopsis Proteins - physiology</subject><subject>Biological and medical sciences</subject><subject>Cell differentiation, maturation, development, hematopoiesis</subject><subject>Cell physiology</subject><subject>Chromatin - genetics</subject><subject>DEVBIO</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Plant</subject><subject>Genome, Plant</subject><subject>Genome-Wide Association Study</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - physiology</subject><subject>Homeostasis</subject><subject>Meristem - genetics</subject><subject>Meristem - physiology</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Plant Stems - physiology</subject><subject>Protein-Serine-Threonine Kinases</subject><subject>Receptor Protein-Tyrosine Kinases - genetics</subject><subject>STEMCELL</subject><subject>Transcription Factors - genetics</subject><subject>Transcription, Genetic</subject><subject>Transcription. Transcription factor. Splicing. 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Psychology</topic><topic>Gene Expression Regulation, Plant</topic><topic>Genome, Plant</topic><topic>Genome-Wide Association Study</topic><topic>Homeodomain Proteins - genetics</topic><topic>Homeodomain Proteins - physiology</topic><topic>Homeostasis</topic><topic>Meristem - genetics</topic><topic>Meristem - physiology</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Plant Stems - physiology</topic><topic>Protein-Serine-Threonine Kinases</topic><topic>Receptor Protein-Tyrosine Kinases - genetics</topic><topic>STEMCELL</topic><topic>Transcription Factors - genetics</topic><topic>Transcription, Genetic</topic><topic>Transcription. Transcription factor. Splicing. 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Here, we report the genome-wide regulatory potential of WUSCHEL, the key transcription factor for stem cell maintenance in the shoot apical meristem of the reference plant
Arabidopsis thaliana. WUSCHEL acts by directly binding to at least two distinct DNA motifs in more than 100 target promoters and preferentially affects the expression of genes with roles in hormone signaling, metabolism, and development. Striking examples are the direct transcriptional repression of
CLAVATA1, which is part of a negative feedback regulation of
WUSCHEL, and the immediate regulation of transcriptional repressors of the TOPLESS family, which are involved in auxin signaling. Our results shed light on the complex transcriptional programs required for the maintenance of a dynamic and essential stem cell niche.
[Display omitted]
► WUSCHEL (WUS) regulates genes with roles in metabolism, development, and signaling ► WUS binds to at least two diverse DNA motifs with different affinity ► WUS associates with more than 100 chromatin regions in vivo ► Direct WUS targets include key regulators, such as
CLAVATA1 and
TOPLESS</abstract><cop>Cambridge, MA</cop><pub>Elsevier Inc</pub><pmid>20493817</pmid><doi>10.1016/j.devcel.2010.03.012</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Developmental cell, 2010-05, Vol.18 (5), p.841-853 |
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| source | MEDLINE; Open Access: Cell Press Free Archives; Elsevier ScienceDirect Journals; EZB Electronic Journals Library |
| subjects | Arabidopsis - genetics Arabidopsis - growth & development Arabidopsis Proteins - genetics Arabidopsis Proteins - physiology Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell physiology Chromatin - genetics DEVBIO DNA-Binding Proteins - genetics Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Plant Genome, Plant Genome-Wide Association Study Homeodomain Proteins - genetics Homeodomain Proteins - physiology Homeostasis Meristem - genetics Meristem - physiology Molecular and cellular biology Molecular genetics Plant Stems - physiology Protein-Serine-Threonine Kinases Receptor Protein-Tyrosine Kinases - genetics STEMCELL Transcription Factors - genetics Transcription, Genetic Transcription. Transcription factor. Splicing. Rna processing |
| title | Transcriptional Control of a Plant Stem Cell Niche |
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