Hypothalamic Orexin Stimulates Feeding-Associated Glucose Utilization in Skeletal Muscle via Sympathetic Nervous System

Hypothalamic neurons containing orexin (hypocretin) are activated during motivated behaviors and active waking. We show that injection of orexin-A into the ventromedial hypothalamus (VMH) of mice or rats increased glucose uptake and promoted insulin-induced glucose uptake and glycogen synthesis in s...

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Veröffentlicht in:	Cell metabolism 2009-12, Vol.10 (6), p.466-480
Hauptverfasser:	Shiuchi, Tetsuya, Haque, Mohammad Shahidul, Okamoto, Shiki, Inoue, Tsuyoshi, Kageyama, Haruaki, Lee, Suni, Toda, Chitoku, Suzuki, Atsushi, Bachman, Eric S., Kim, Young-Bum, Sakurai, Takashi, Yanagisawa, Masashi, Shioda, Seiji, Imoto, Keiji, Minokoshi, Yasuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue, White - metabolism Animals Feeding Behavior - physiology Glucose - metabolism Glycogen - biosynthesis HUMDISEASE Insulin - metabolism Intracellular Signaling Peptides and Proteins - metabolism Intracellular Signaling Peptides and Proteins - pharmacology Male Mice Motivation - physiology Muscle, Skeletal - metabolism Neuropeptides - metabolism Neuropeptides - pharmacology Orexin Receptors Orexins Rats Receptors, Adrenergic, beta - metabolism Receptors, G-Protein-Coupled - metabolism Receptors, Neuropeptide - metabolism Sympathetic Nervous System - metabolism Sympathomimetics - metabolism Sympathomimetics - pharmacology Ventromedial Hypothalamic Nucleus - drug effects Ventromedial Hypothalamic Nucleus - physiology
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