Resistance of metallothionein-III null mice to cadmium-induced acute hepatotoxicity

We examined the sensitivity of metallothionein (MT)-III null mice to cadmium (Cd)-induced acute hepatotoxicity. MT-I/II null mice were also used to compare Cd toxicities between MT-III null mice and MT-I/II null mice. Male MT-I/II null mice, MT-III null mice and wild-type mice were given s.c. inject...

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Veröffentlicht in:	Journal of toxicological sciences 2010, Vol.35(2), pp.209-215
Hauptverfasser:	Honda, Akiko, Komuro, Hiroaki, Hasegawa, Tatsuya, Seko, Yoshiyuki, Shimada, Akinori, Nagase, Hisamitsu, Hozumi, Isao, Inuzuka, Takashi, Hara, Hideaki, Fujiwara, Yasuyuki, Satoh, Masahiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood Animals Aspartate Aminotransferases - blood Cadmium - toxicity Hepatotoxicity Knockout mice Liver - drug effects Liver - pathology Male Mice MT-I/II MT-III Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology RNA, Messenger - analysis
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