The hepatitis B virus X protein disrupts innate immunity by downregulating mitochondrial antiviral signaling protein

Previous studies have shown that both hepatitis A virus and hepatitis C virus inhibit innate immunity by cleaving the mitochondrial antiviral signaling (MAVS) protein, an essential component of the virus-activated signaling pathway that activates NF-kappaB and IFN regulatory factor-3 to induce the p...

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Veröffentlicht in:	The Journal of immunology (1950) 2010-07, Vol.185 (2), p.1158-1168
Hauptverfasser:	Wei, Congwen, Ni, Caifei, Song, Ting, Liu, Yu, Yang, XiaoLi, Zheng, Zirui, Jia, Yongxia, Yuan, Yuan, Guan, Kai, Xu, Yang, Cheng, Xiaozhong, Zhang, Yanhong, Yang, Xiao, Wang, Youliang, Wen, Chaoyang, Wu, Qing, Shi, Wei, Zhong, Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - immunology Adaptor Proteins, Signal Transducing - metabolism Animals Cell Line Chlorocebus aethiops DEAD Box Protein 58 DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - immunology DEAD-box RNA Helicases - metabolism Down-Regulation Hep G2 Cells Humans Immunity, Innate - immunology Immunoblotting Interferon-gamma - genetics Interferon-gamma - immunology Interferon-gamma - metabolism Kinetics Mitochondrial Proteins - genetics Mitochondrial Proteins - immunology Mitochondrial Proteins - metabolism Poly dA-dT - genetics Poly dA-dT - immunology Poly dA-dT - metabolism Protein Binding Receptors, Immunologic Reverse Transcriptase Polymerase Chain Reaction Signal Transduction - immunology Trans-Activators - genetics Trans-Activators - immunology Trans-Activators - metabolism Transfection Vero Cells Viral Regulatory and Accessory Proteins
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