Hepatosplenic alphabeta T cell lymphoma
A 32-year-old male with chronic hepatitis B was admitted to a hospital with cellulitis in the right leg in September 2006. Pancytopenia, hepatosplenomegaly, and systemic superficial lymph node swelling were noted, and he was referred to our hospital. He developed fever and liver dysfunction in June...
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| Veröffentlicht in: | International journal of clinical oncology 2010-04, Vol.15 (2), p.215-219 |
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| creator | Nagai, Yuya Ikegame, Kazuhiro Mori, Minako Inoue, Daichi Kimura, Takaharu Shimoji, Sonoko Togami, Katsuhiro Tabata, Sumie Kurata, Masayuki Imai, Yukihiro Matsushita, Akiko Nagai, Kenichi Ogawa, Hiroyasu Takahashi, Takayuki |
| description | A 32-year-old male with chronic hepatitis B was admitted to a hospital with cellulitis in the right leg in September 2006. Pancytopenia, hepatosplenomegaly, and systemic superficial lymph node swelling were noted, and he was referred to our hospital. He developed fever and liver dysfunction in June 2007 and underwent a splenectomy. His pancytopenia subsequently improved. A pathologic diagnosis of hepatosplenic alphabeta T cell lymphoma was made by examining spleen tissue and biopsy specimens of the liver and mesenteric lymph node. He had stage IVB disease because neoplastic T cells were noted in the bone marrow. The response of the lymphoma to conventional chemotherapy including the CHOP (cyclophosphamide, adriamycin, vincristine, prednisolone) and DeVIC (dexamethasone, etoposide, ifoshamide, carboplatin) regimens was poor and transient. A partial remission was obtained with an ESHAP (etoposide, cisplatin, cytarabine, methylprednisolone) regimen. Therefore, we planned a bone marrow transplantation (BMT) from an HLA-haploidentical sibling donor. He was moved to the Department of Hematology, Hyogo Medical College, to receive this BMT as part of a clinical trial. During the conditioning procedure for the transplantation, however, he died of septicemia. Since hepatosplenic alphabeta T cell lymphoma is very rare with only 23 reported cases to date, herein we report this case and discuss the therapeutic strategy. |
| doi_str_mv | 10.1007/s10147-010-0028-y |
| format | Article |
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Pancytopenia, hepatosplenomegaly, and systemic superficial lymph node swelling were noted, and he was referred to our hospital. He developed fever and liver dysfunction in June 2007 and underwent a splenectomy. His pancytopenia subsequently improved. A pathologic diagnosis of hepatosplenic alphabeta T cell lymphoma was made by examining spleen tissue and biopsy specimens of the liver and mesenteric lymph node. He had stage IVB disease because neoplastic T cells were noted in the bone marrow. The response of the lymphoma to conventional chemotherapy including the CHOP (cyclophosphamide, adriamycin, vincristine, prednisolone) and DeVIC (dexamethasone, etoposide, ifoshamide, carboplatin) regimens was poor and transient. A partial remission was obtained with an ESHAP (etoposide, cisplatin, cytarabine, methylprednisolone) regimen. Therefore, we planned a bone marrow transplantation (BMT) from an HLA-haploidentical sibling donor. He was moved to the Department of Hematology, Hyogo Medical College, to receive this BMT as part of a clinical trial. During the conditioning procedure for the transplantation, however, he died of septicemia. Since hepatosplenic alphabeta T cell lymphoma is very rare with only 23 reported cases to date, herein we report this case and discuss the therapeutic strategy.</description><identifier>EISSN: 1437-7772</identifier><identifier>DOI: 10.1007/s10147-010-0028-y</identifier><identifier>PMID: 20217452</identifier><language>eng</language><publisher>Japan</publisher><subject><![CDATA[Adult ; Antineoplastic Combined Chemotherapy Protocols - administration & dosage ; Biopsy ; Bone Marrow Transplantation ; Carboplatin - administration & dosage ; Cisplatin - administration & dosage ; Cyclophosphamide - administration & dosage ; Cytarabine - administration & dosage ; Dexamethasone - administration & dosage ; Doxorubicin - administration & dosage ; Etoposide - administration & dosage ; Fatal Outcome ; Hematopoietic Stem Cell Transplantation ; Humans ; Ifosfamide - administration & dosage ; Liver Neoplasms - diagnosis ; Liver Neoplasms - immunology ; Liver Neoplasms - therapy ; Lymphoma, T-Cell - diagnosis ; Lymphoma, T-Cell - immunology ; Lymphoma, T-Cell - therapy ; Male ; Methylprednisolone - administration & dosage ; Positron-Emission Tomography ; Prednisolone - administration & dosage ; Receptors, Antigen, T-Cell, alpha-beta - immunology ; Splenic Neoplasms - diagnosis ; Splenic Neoplasms - immunology ; Splenic Neoplasms - therapy ; T-Lymphocytes - immunology ; Tomography, X-Ray Computed ; Transplantation Conditioning ; Vincristine - administration & dosage]]></subject><ispartof>International journal of clinical oncology, 2010-04, Vol.15 (2), p.215-219</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20217452$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nagai, Yuya</creatorcontrib><creatorcontrib>Ikegame, Kazuhiro</creatorcontrib><creatorcontrib>Mori, Minako</creatorcontrib><creatorcontrib>Inoue, Daichi</creatorcontrib><creatorcontrib>Kimura, Takaharu</creatorcontrib><creatorcontrib>Shimoji, Sonoko</creatorcontrib><creatorcontrib>Togami, Katsuhiro</creatorcontrib><creatorcontrib>Tabata, Sumie</creatorcontrib><creatorcontrib>Kurata, Masayuki</creatorcontrib><creatorcontrib>Imai, Yukihiro</creatorcontrib><creatorcontrib>Matsushita, Akiko</creatorcontrib><creatorcontrib>Nagai, Kenichi</creatorcontrib><creatorcontrib>Ogawa, Hiroyasu</creatorcontrib><creatorcontrib>Takahashi, Takayuki</creatorcontrib><title>Hepatosplenic alphabeta T cell lymphoma</title><title>International journal of clinical oncology</title><addtitle>Int J Clin Oncol</addtitle><description>A 32-year-old male with chronic hepatitis B was admitted to a hospital with cellulitis in the right leg in September 2006. Pancytopenia, hepatosplenomegaly, and systemic superficial lymph node swelling were noted, and he was referred to our hospital. He developed fever and liver dysfunction in June 2007 and underwent a splenectomy. His pancytopenia subsequently improved. A pathologic diagnosis of hepatosplenic alphabeta T cell lymphoma was made by examining spleen tissue and biopsy specimens of the liver and mesenteric lymph node. He had stage IVB disease because neoplastic T cells were noted in the bone marrow. The response of the lymphoma to conventional chemotherapy including the CHOP (cyclophosphamide, adriamycin, vincristine, prednisolone) and DeVIC (dexamethasone, etoposide, ifoshamide, carboplatin) regimens was poor and transient. A partial remission was obtained with an ESHAP (etoposide, cisplatin, cytarabine, methylprednisolone) regimen. Therefore, we planned a bone marrow transplantation (BMT) from an HLA-haploidentical sibling donor. He was moved to the Department of Hematology, Hyogo Medical College, to receive this BMT as part of a clinical trial. During the conditioning procedure for the transplantation, however, he died of septicemia. Since hepatosplenic alphabeta T cell lymphoma is very rare with only 23 reported cases to date, herein we report this case and discuss the therapeutic strategy.</description><subject>Adult</subject><subject>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</subject><subject>Biopsy</subject><subject>Bone Marrow Transplantation</subject><subject>Carboplatin - administration & dosage</subject><subject>Cisplatin - administration & dosage</subject><subject>Cyclophosphamide - administration & dosage</subject><subject>Cytarabine - administration & dosage</subject><subject>Dexamethasone - administration & dosage</subject><subject>Doxorubicin - administration & dosage</subject><subject>Etoposide - administration & dosage</subject><subject>Fatal Outcome</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Humans</subject><subject>Ifosfamide - administration & dosage</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Liver Neoplasms - immunology</subject><subject>Liver Neoplasms - therapy</subject><subject>Lymphoma, T-Cell - diagnosis</subject><subject>Lymphoma, T-Cell - immunology</subject><subject>Lymphoma, T-Cell - therapy</subject><subject>Male</subject><subject>Methylprednisolone - administration & dosage</subject><subject>Positron-Emission Tomography</subject><subject>Prednisolone - administration & dosage</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - immunology</subject><subject>Splenic Neoplasms - diagnosis</subject><subject>Splenic Neoplasms - immunology</subject><subject>Splenic Neoplasms - therapy</subject><subject>T-Lymphocytes - immunology</subject><subject>Tomography, X-Ray Computed</subject><subject>Transplantation Conditioning</subject><subject>Vincristine - administration & dosage</subject><issn>1437-7772</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j71OwzAURi0kREvhAVhQtk6Ge_3bjKgCilSJJXvk2NdqUNKYOB3y9hRRpm85-nQOYw8ITwhgnzMCKssBgQOIDZ-v2BKVtNxaKxbsNucvALRGixu2ECDQKi2WbL2j5KYhp46OrS9clw6uockVVeGp64pu7tNh6N0du46uy3R_2RWr3l6r7Y7vP98_ti97nrQW3HmMhNZG7TfohTbUNIEMOFChbEDF6Mj4EGLAEklAjKUMxvt4VldKNnLF1n-3aRy-T5Snum_zr4g70nDKtZXSSKkRzuTjhTw1PYU6jW3vxrn-T5M_v95Oug</recordid><startdate>201004</startdate><enddate>201004</enddate><creator>Nagai, Yuya</creator><creator>Ikegame, Kazuhiro</creator><creator>Mori, Minako</creator><creator>Inoue, Daichi</creator><creator>Kimura, Takaharu</creator><creator>Shimoji, Sonoko</creator><creator>Togami, Katsuhiro</creator><creator>Tabata, Sumie</creator><creator>Kurata, Masayuki</creator><creator>Imai, Yukihiro</creator><creator>Matsushita, Akiko</creator><creator>Nagai, Kenichi</creator><creator>Ogawa, Hiroyasu</creator><creator>Takahashi, Takayuki</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201004</creationdate><title>Hepatosplenic alphabeta T cell lymphoma</title><author>Nagai, Yuya ; 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Pancytopenia, hepatosplenomegaly, and systemic superficial lymph node swelling were noted, and he was referred to our hospital. He developed fever and liver dysfunction in June 2007 and underwent a splenectomy. His pancytopenia subsequently improved. A pathologic diagnosis of hepatosplenic alphabeta T cell lymphoma was made by examining spleen tissue and biopsy specimens of the liver and mesenteric lymph node. He had stage IVB disease because neoplastic T cells were noted in the bone marrow. The response of the lymphoma to conventional chemotherapy including the CHOP (cyclophosphamide, adriamycin, vincristine, prednisolone) and DeVIC (dexamethasone, etoposide, ifoshamide, carboplatin) regimens was poor and transient. A partial remission was obtained with an ESHAP (etoposide, cisplatin, cytarabine, methylprednisolone) regimen. Therefore, we planned a bone marrow transplantation (BMT) from an HLA-haploidentical sibling donor. He was moved to the Department of Hematology, Hyogo Medical College, to receive this BMT as part of a clinical trial. During the conditioning procedure for the transplantation, however, he died of septicemia. Since hepatosplenic alphabeta T cell lymphoma is very rare with only 23 reported cases to date, herein we report this case and discuss the therapeutic strategy.</abstract><cop>Japan</cop><pmid>20217452</pmid><doi>10.1007/s10147-010-0028-y</doi><tpages>5</tpages></addata></record> |
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| ispartof | International journal of clinical oncology, 2010-04, Vol.15 (2), p.215-219 |
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| subjects | Adult Antineoplastic Combined Chemotherapy Protocols - administration & dosage Biopsy Bone Marrow Transplantation Carboplatin - administration & dosage Cisplatin - administration & dosage Cyclophosphamide - administration & dosage Cytarabine - administration & dosage Dexamethasone - administration & dosage Doxorubicin - administration & dosage Etoposide - administration & dosage Fatal Outcome Hematopoietic Stem Cell Transplantation Humans Ifosfamide - administration & dosage Liver Neoplasms - diagnosis Liver Neoplasms - immunology Liver Neoplasms - therapy Lymphoma, T-Cell - diagnosis Lymphoma, T-Cell - immunology Lymphoma, T-Cell - therapy Male Methylprednisolone - administration & dosage Positron-Emission Tomography Prednisolone - administration & dosage Receptors, Antigen, T-Cell, alpha-beta - immunology Splenic Neoplasms - diagnosis Splenic Neoplasms - immunology Splenic Neoplasms - therapy T-Lymphocytes - immunology Tomography, X-Ray Computed Transplantation Conditioning Vincristine - administration & dosage |
| title | Hepatosplenic alphabeta T cell lymphoma |
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