Novel Cyclopeptides for the Design of MMP Directed Delivery Devices: A Novel Smart Delivery Paradigm

Purpose Matrix metalloproteinases (MMP) are a family of proteolytic enzymes, the expression of which in a key step of tumor progression has been better defined recently. The studies highlighted the ongoing need for very specific inhibitors, substrates or release devices designed to be selective for...

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Veröffentlicht in:	Pharmaceutical research 2010-08, Vol.27 (8), p.1713-1721
Hauptverfasser:	Moustoifa, El-Farouck, Alouini, Mohamed-Anis, Salaün, Arnaud, Berthelot, Thomas, Bartegi, Aghleb, Albenque-Rubio, Sandra, Déléris, Gérard
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Biochemistry Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine cyclic peptide Cyclization delivery device Drug Delivery Systems Drug Design Enzymes Fluorescence Resonance Energy Transfer fluorescent substrate Gene expression General pharmacology Humans Kinetics Matrix Metalloproteinase Inhibitors Medical Law Medical sciences MMP Molecular Sequence Data neoplasms Peptides Peptides - chemical synthesis Peptides - therapeutic use Pharmaceutical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacy Research Paper
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