Detection of Kinase Activity Using Versatile Fluorescence Quencher Probes

Turn off the light! A kinase assay system employs fluorescent peptides and a phosphate‐selective fluorescence quencher probe, and can be placed on a microfluidic chip (see picture). The system can be used for real‐time kinase monitoring, kinase inhibitor screening, and cancer diagnosis based on abno...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2010-07, Vol.49 (29), p.4919-4923
Hauptverfasser:	Rhee, Hyun-Woo, Lee, Seung Hwan, Shin, Ik-Soo, Choi, So Jung, Park, Hun Hee, Han, Kyungja, Park, Tai Hyun, Hong, Jong-In
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism cancer Casein Kinase II - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism fluorescence Fluorescent Dyes - chemistry fluorescent probes Heterocyclic Compounds, 3-Ring - chemistry Humans kinases Microfluidic Analytical Techniques - methods Neoplasms - diagnosis Neoplasms - enzymology Phosphorylation Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Protein Kinases - chemistry Protein Kinases - metabolism Proto-Oncogene Proteins c-abl - metabolism
Online-Zugang:	Volltext
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