Mitogen-activated protein kinases pathway is involved in physiological testosterone-induced tissue factor pathway inhibitor expression in endothelial cells

The mechanism of testosterone inducing the tissue factor pathway inhibitor (TFPI) in protecting against thrombosis is unknown. We aimed to elucidate the mechanisms involved in the induction by observing, in human umbilical vein endothelial cells (HUVECs), the phosphorylation of mitogen-activated pro...

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Veröffentlicht in:	Blood coagulation & fibrinolysis 2010-07, Vol.21 (5), p.420-424
Hauptverfasser:	Jin, Hong, Wang, Da-yu, Mei, Yi-fang, Qiu, Wen-bing, Zhou, Yi, Wang, Dong-ming, Tan, Xue-rui, Li, Yu-guang
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood coagulation. Blood cells Cells, Cultured Endothelial Cells - drug effects Endothelial Cells - metabolism Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Hematologic and hematopoietic diseases Humans Lipoproteins - biosynthesis Lipoproteins - genetics Lipoproteins - metabolism MAP Kinase Signaling System - drug effects Medical sciences Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Molecular and cellular biology Phosphorylation - drug effects Platelet diseases and coagulopathies Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Testosterone - pharmacology Thrombosis - prevention & control
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