Renal and cardiorespiratory effects of treatment with lactated Ringer's solution or physiologic saline (0.9% NaCl) solution in cats with experimentally induced urethral obstruction
To compare the renal and cardiorespiratory effects of IV treatment with lactated Ringer's solution (LRS) or physiologic saline (0.9% NaCl) solution (PSS) in severely decompensated cats with urethral obstruction (UO). 14 cats (4 cats were used only to establish infusion rates). An occluded ureth...
Gespeichert in:
Veröffentlicht in: | American journal of veterinary research 2010-07, Vol.71 (7), p.840-846 |
---|---|
Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 846 |
---|---|
container_issue | 7 |
container_start_page | 840 |
container_title | American journal of veterinary research |
container_volume | 71 |
creator | Cunha, Marina G.M.C.M Freitas, Gabrielle C Carregaro, Adriano B Gomes, Kleber Cunha, Joäo P.M.C.M Beckmann, Diego V Pippi, Ney L |
description | To compare the renal and cardiorespiratory effects of IV treatment with lactated Ringer's solution (LRS) or physiologic saline (0.9% NaCl) solution (PSS) in severely decompensated cats with urethral obstruction (UO).
14 cats (4 cats were used only to establish infusion rates).
An occluded urethral catheter was used to induce UO in each cat. After development of severe metabolic acidosis, hyperkalemia, and postrenal azotemia, the obstruction was relieved (0 hours); LRS or PSS (5 cats/group) was administered IV (gradually decreasing rate) beginning 15 minutes before and continuing for 48 hours after UO relief. Ten minutes before urethral catheter placement (baseline), at start of fluid therapy (SFT), and at intervals during fluid administration, various physical and clinicopathologic evaluations were performed.
Metabolic acidosis was detected in the PSS-treated group at SFT and 2 hours after relief of UO and in the LRS-treated group only at SFT The PSS-treated group had significantly lower blood pH and bicarbonate concentrations at 8 through 48 hours and lower base excess values at 2 through 48 hours, compared with the LRS-treated group. Hypocalcemia and hypernatremia were detected in the PSS-treated group at 2 and 12 hours, respectively. Absolute serum potassium and chloride concentrations did not differ significantly between groups at any time point.
Treatment with LRS or PSS appeared to be safe and effective in cats with experimentally induced UO; however, LRS was more efficient in restoring the acid-base and electrolyte balance in severely decompensated cats with UO. |
doi_str_mv | 10.2460/ajvr.71.7.840 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733627263</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733627263</sourcerecordid><originalsourceid>FETCH-LOGICAL-c355t-11ab2183876ed0b8b0c1045e56579c5b4b519ed65456ff3c1117df838397c0703</originalsourceid><addsrcrecordid>eNpFkU1v1DAQhi0EokvhyBV8QYVDgieOY-eIVuVDqkAq9Gw5zmTXlTdebAe6_4sfiJctcJqDHz_vjF5CngOrm7Zjb83tj1hLqGWtWvaArKBveSU6BQ_JijHWVH3XijPyJKVbxqBRIB6Ts4aJvmVKrciva5yNp2YeqTVxdCFi2rtocogHitOENicaJpojmrzDOdOfLm-pNzabjCO9dvMG40WiKfgluzDTEOl-e0gu-LBxlibj3Yz0Nav7V_SzWfs3_1E3l9Di_6PEuz1Gd4ww3h_K27jYErBEzNtYVgxDynGxx49PyaPJ-ITP7uc5uXl_-W39sbr68uHT-t1VZbkQuQIwQwOKK9nhyAY1MAusFSg6IXsrhnYQ0OPYiVZ008QtAMhxKjzvpWWS8XNycfLuY_i-YMp655JF782MYUlact41sul4IasTaWNIKeKk9-UWEw8amD72pI89aQla6tJT4V_cm5dhh-M_-m8xBXh5AiYTtNlEl_TN14YBZ6CkBKn4b4Y1m5A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733627263</pqid></control><display><type>article</type><title>Renal and cardiorespiratory effects of treatment with lactated Ringer's solution or physiologic saline (0.9% NaCl) solution in cats with experimentally induced urethral obstruction</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Cunha, Marina G.M.C.M ; Freitas, Gabrielle C ; Carregaro, Adriano B ; Gomes, Kleber ; Cunha, Joäo P.M.C.M ; Beckmann, Diego V ; Pippi, Ney L</creator><creatorcontrib>Cunha, Marina G.M.C.M ; Freitas, Gabrielle C ; Carregaro, Adriano B ; Gomes, Kleber ; Cunha, Joäo P.M.C.M ; Beckmann, Diego V ; Pippi, Ney L</creatorcontrib><description>To compare the renal and cardiorespiratory effects of IV treatment with lactated Ringer's solution (LRS) or physiologic saline (0.9% NaCl) solution (PSS) in severely decompensated cats with urethral obstruction (UO).
14 cats (4 cats were used only to establish infusion rates).
An occluded urethral catheter was used to induce UO in each cat. After development of severe metabolic acidosis, hyperkalemia, and postrenal azotemia, the obstruction was relieved (0 hours); LRS or PSS (5 cats/group) was administered IV (gradually decreasing rate) beginning 15 minutes before and continuing for 48 hours after UO relief. Ten minutes before urethral catheter placement (baseline), at start of fluid therapy (SFT), and at intervals during fluid administration, various physical and clinicopathologic evaluations were performed.
Metabolic acidosis was detected in the PSS-treated group at SFT and 2 hours after relief of UO and in the LRS-treated group only at SFT The PSS-treated group had significantly lower blood pH and bicarbonate concentrations at 8 through 48 hours and lower base excess values at 2 through 48 hours, compared with the LRS-treated group. Hypocalcemia and hypernatremia were detected in the PSS-treated group at 2 and 12 hours, respectively. Absolute serum potassium and chloride concentrations did not differ significantly between groups at any time point.
Treatment with LRS or PSS appeared to be safe and effective in cats with experimentally induced UO; however, LRS was more efficient in restoring the acid-base and electrolyte balance in severely decompensated cats with UO.</description><identifier>ISSN: 0002-9645</identifier><identifier>EISSN: 1943-5681</identifier><identifier>DOI: 10.2460/ajvr.71.7.840</identifier><identifier>PMID: 20594088</identifier><language>eng</language><publisher>United States</publisher><subject>acid-base balance ; Animals ; aqueous solutions ; Body Temperature - drug effects ; cardiovascular system ; cat diseases ; Cat Diseases - drug therapy ; Cat Diseases - physiopathology ; Cats ; circulatory system physiology ; complications ; disease course ; Diuresis - drug effects ; drug evaluation ; drug therapy ; electrolytes ; fluid therapy ; Fluid Therapy - methods ; Fluid Therapy - veterinary ; Heart Rate - drug effects ; intravenous injection ; Isotonic Solutions - therapeutic use ; Kidney - drug effects ; Kidney - physiology ; Kidney - physiopathology ; kidney diseases ; lactated Ringer's solution ; Male ; metabolic diseases ; metabolites ; Orchiectomy ; pharmacokinetics ; physiologic saline solution ; physiological response ; renal function ; respiratory physiology ; Ringer's solution ; saline solution ; Serum Albumin - drug effects ; Serum Albumin - metabolism ; sodium chloride ; Sodium Chloride - therapeutic use ; urethra ; urethral obstruction ; Urethral Obstruction - drug therapy ; Urethral Obstruction - physiopathology ; Urethral Obstruction - veterinary ; urinary tract diseases</subject><ispartof>American journal of veterinary research, 2010-07, Vol.71 (7), p.840-846</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-11ab2183876ed0b8b0c1045e56579c5b4b519ed65456ff3c1117df838397c0703</citedby><cites>FETCH-LOGICAL-c355t-11ab2183876ed0b8b0c1045e56579c5b4b519ed65456ff3c1117df838397c0703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20594088$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cunha, Marina G.M.C.M</creatorcontrib><creatorcontrib>Freitas, Gabrielle C</creatorcontrib><creatorcontrib>Carregaro, Adriano B</creatorcontrib><creatorcontrib>Gomes, Kleber</creatorcontrib><creatorcontrib>Cunha, Joäo P.M.C.M</creatorcontrib><creatorcontrib>Beckmann, Diego V</creatorcontrib><creatorcontrib>Pippi, Ney L</creatorcontrib><title>Renal and cardiorespiratory effects of treatment with lactated Ringer's solution or physiologic saline (0.9% NaCl) solution in cats with experimentally induced urethral obstruction</title><title>American journal of veterinary research</title><addtitle>Am J Vet Res</addtitle><description>To compare the renal and cardiorespiratory effects of IV treatment with lactated Ringer's solution (LRS) or physiologic saline (0.9% NaCl) solution (PSS) in severely decompensated cats with urethral obstruction (UO).
14 cats (4 cats were used only to establish infusion rates).
An occluded urethral catheter was used to induce UO in each cat. After development of severe metabolic acidosis, hyperkalemia, and postrenal azotemia, the obstruction was relieved (0 hours); LRS or PSS (5 cats/group) was administered IV (gradually decreasing rate) beginning 15 minutes before and continuing for 48 hours after UO relief. Ten minutes before urethral catheter placement (baseline), at start of fluid therapy (SFT), and at intervals during fluid administration, various physical and clinicopathologic evaluations were performed.
Metabolic acidosis was detected in the PSS-treated group at SFT and 2 hours after relief of UO and in the LRS-treated group only at SFT The PSS-treated group had significantly lower blood pH and bicarbonate concentrations at 8 through 48 hours and lower base excess values at 2 through 48 hours, compared with the LRS-treated group. Hypocalcemia and hypernatremia were detected in the PSS-treated group at 2 and 12 hours, respectively. Absolute serum potassium and chloride concentrations did not differ significantly between groups at any time point.
Treatment with LRS or PSS appeared to be safe and effective in cats with experimentally induced UO; however, LRS was more efficient in restoring the acid-base and electrolyte balance in severely decompensated cats with UO.</description><subject>acid-base balance</subject><subject>Animals</subject><subject>aqueous solutions</subject><subject>Body Temperature - drug effects</subject><subject>cardiovascular system</subject><subject>cat diseases</subject><subject>Cat Diseases - drug therapy</subject><subject>Cat Diseases - physiopathology</subject><subject>Cats</subject><subject>circulatory system physiology</subject><subject>complications</subject><subject>disease course</subject><subject>Diuresis - drug effects</subject><subject>drug evaluation</subject><subject>drug therapy</subject><subject>electrolytes</subject><subject>fluid therapy</subject><subject>Fluid Therapy - methods</subject><subject>Fluid Therapy - veterinary</subject><subject>Heart Rate - drug effects</subject><subject>intravenous injection</subject><subject>Isotonic Solutions - therapeutic use</subject><subject>Kidney - drug effects</subject><subject>Kidney - physiology</subject><subject>Kidney - physiopathology</subject><subject>kidney diseases</subject><subject>lactated Ringer's solution</subject><subject>Male</subject><subject>metabolic diseases</subject><subject>metabolites</subject><subject>Orchiectomy</subject><subject>pharmacokinetics</subject><subject>physiologic saline solution</subject><subject>physiological response</subject><subject>renal function</subject><subject>respiratory physiology</subject><subject>Ringer's solution</subject><subject>saline solution</subject><subject>Serum Albumin - drug effects</subject><subject>Serum Albumin - metabolism</subject><subject>sodium chloride</subject><subject>Sodium Chloride - therapeutic use</subject><subject>urethra</subject><subject>urethral obstruction</subject><subject>Urethral Obstruction - drug therapy</subject><subject>Urethral Obstruction - physiopathology</subject><subject>Urethral Obstruction - veterinary</subject><subject>urinary tract diseases</subject><issn>0002-9645</issn><issn>1943-5681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1v1DAQhi0EokvhyBV8QYVDgieOY-eIVuVDqkAq9Gw5zmTXlTdebAe6_4sfiJctcJqDHz_vjF5CngOrm7Zjb83tj1hLqGWtWvaArKBveSU6BQ_JijHWVH3XijPyJKVbxqBRIB6Ts4aJvmVKrciva5yNp2YeqTVxdCFi2rtocogHitOENicaJpojmrzDOdOfLm-pNzabjCO9dvMG40WiKfgluzDTEOl-e0gu-LBxlibj3Yz0Nav7V_SzWfs3_1E3l9Di_6PEuz1Gd4ww3h_K27jYErBEzNtYVgxDynGxx49PyaPJ-ITP7uc5uXl_-W39sbr68uHT-t1VZbkQuQIwQwOKK9nhyAY1MAusFSg6IXsrhnYQ0OPYiVZ008QtAMhxKjzvpWWS8XNycfLuY_i-YMp655JF782MYUlact41sul4IasTaWNIKeKk9-UWEw8amD72pI89aQla6tJT4V_cm5dhh-M_-m8xBXh5AiYTtNlEl_TN14YBZ6CkBKn4b4Y1m5A</recordid><startdate>20100701</startdate><enddate>20100701</enddate><creator>Cunha, Marina G.M.C.M</creator><creator>Freitas, Gabrielle C</creator><creator>Carregaro, Adriano B</creator><creator>Gomes, Kleber</creator><creator>Cunha, Joäo P.M.C.M</creator><creator>Beckmann, Diego V</creator><creator>Pippi, Ney L</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100701</creationdate><title>Renal and cardiorespiratory effects of treatment with lactated Ringer's solution or physiologic saline (0.9% NaCl) solution in cats with experimentally induced urethral obstruction</title><author>Cunha, Marina G.M.C.M ; Freitas, Gabrielle C ; Carregaro, Adriano B ; Gomes, Kleber ; Cunha, Joäo P.M.C.M ; Beckmann, Diego V ; Pippi, Ney L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-11ab2183876ed0b8b0c1045e56579c5b4b519ed65456ff3c1117df838397c0703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>acid-base balance</topic><topic>Animals</topic><topic>aqueous solutions</topic><topic>Body Temperature - drug effects</topic><topic>cardiovascular system</topic><topic>cat diseases</topic><topic>Cat Diseases - drug therapy</topic><topic>Cat Diseases - physiopathology</topic><topic>Cats</topic><topic>circulatory system physiology</topic><topic>complications</topic><topic>disease course</topic><topic>Diuresis - drug effects</topic><topic>drug evaluation</topic><topic>drug therapy</topic><topic>electrolytes</topic><topic>fluid therapy</topic><topic>Fluid Therapy - methods</topic><topic>Fluid Therapy - veterinary</topic><topic>Heart Rate - drug effects</topic><topic>intravenous injection</topic><topic>Isotonic Solutions - therapeutic use</topic><topic>Kidney - drug effects</topic><topic>Kidney - physiology</topic><topic>Kidney - physiopathology</topic><topic>kidney diseases</topic><topic>lactated Ringer's solution</topic><topic>Male</topic><topic>metabolic diseases</topic><topic>metabolites</topic><topic>Orchiectomy</topic><topic>pharmacokinetics</topic><topic>physiologic saline solution</topic><topic>physiological response</topic><topic>renal function</topic><topic>respiratory physiology</topic><topic>Ringer's solution</topic><topic>saline solution</topic><topic>Serum Albumin - drug effects</topic><topic>Serum Albumin - metabolism</topic><topic>sodium chloride</topic><topic>Sodium Chloride - therapeutic use</topic><topic>urethra</topic><topic>urethral obstruction</topic><topic>Urethral Obstruction - drug therapy</topic><topic>Urethral Obstruction - physiopathology</topic><topic>Urethral Obstruction - veterinary</topic><topic>urinary tract diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cunha, Marina G.M.C.M</creatorcontrib><creatorcontrib>Freitas, Gabrielle C</creatorcontrib><creatorcontrib>Carregaro, Adriano B</creatorcontrib><creatorcontrib>Gomes, Kleber</creatorcontrib><creatorcontrib>Cunha, Joäo P.M.C.M</creatorcontrib><creatorcontrib>Beckmann, Diego V</creatorcontrib><creatorcontrib>Pippi, Ney L</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of veterinary research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cunha, Marina G.M.C.M</au><au>Freitas, Gabrielle C</au><au>Carregaro, Adriano B</au><au>Gomes, Kleber</au><au>Cunha, Joäo P.M.C.M</au><au>Beckmann, Diego V</au><au>Pippi, Ney L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renal and cardiorespiratory effects of treatment with lactated Ringer's solution or physiologic saline (0.9% NaCl) solution in cats with experimentally induced urethral obstruction</atitle><jtitle>American journal of veterinary research</jtitle><addtitle>Am J Vet Res</addtitle><date>2010-07-01</date><risdate>2010</risdate><volume>71</volume><issue>7</issue><spage>840</spage><epage>846</epage><pages>840-846</pages><issn>0002-9645</issn><eissn>1943-5681</eissn><abstract>To compare the renal and cardiorespiratory effects of IV treatment with lactated Ringer's solution (LRS) or physiologic saline (0.9% NaCl) solution (PSS) in severely decompensated cats with urethral obstruction (UO).
14 cats (4 cats were used only to establish infusion rates).
An occluded urethral catheter was used to induce UO in each cat. After development of severe metabolic acidosis, hyperkalemia, and postrenal azotemia, the obstruction was relieved (0 hours); LRS or PSS (5 cats/group) was administered IV (gradually decreasing rate) beginning 15 minutes before and continuing for 48 hours after UO relief. Ten minutes before urethral catheter placement (baseline), at start of fluid therapy (SFT), and at intervals during fluid administration, various physical and clinicopathologic evaluations were performed.
Metabolic acidosis was detected in the PSS-treated group at SFT and 2 hours after relief of UO and in the LRS-treated group only at SFT The PSS-treated group had significantly lower blood pH and bicarbonate concentrations at 8 through 48 hours and lower base excess values at 2 through 48 hours, compared with the LRS-treated group. Hypocalcemia and hypernatremia were detected in the PSS-treated group at 2 and 12 hours, respectively. Absolute serum potassium and chloride concentrations did not differ significantly between groups at any time point.
Treatment with LRS or PSS appeared to be safe and effective in cats with experimentally induced UO; however, LRS was more efficient in restoring the acid-base and electrolyte balance in severely decompensated cats with UO.</abstract><cop>United States</cop><pmid>20594088</pmid><doi>10.2460/ajvr.71.7.840</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0002-9645 |
ispartof | American journal of veterinary research, 2010-07, Vol.71 (7), p.840-846 |
issn | 0002-9645 1943-5681 |
language | eng |
recordid | cdi_proquest_miscellaneous_733627263 |
source | MEDLINE; Alma/SFX Local Collection |
subjects | acid-base balance Animals aqueous solutions Body Temperature - drug effects cardiovascular system cat diseases Cat Diseases - drug therapy Cat Diseases - physiopathology Cats circulatory system physiology complications disease course Diuresis - drug effects drug evaluation drug therapy electrolytes fluid therapy Fluid Therapy - methods Fluid Therapy - veterinary Heart Rate - drug effects intravenous injection Isotonic Solutions - therapeutic use Kidney - drug effects Kidney - physiology Kidney - physiopathology kidney diseases lactated Ringer's solution Male metabolic diseases metabolites Orchiectomy pharmacokinetics physiologic saline solution physiological response renal function respiratory physiology Ringer's solution saline solution Serum Albumin - drug effects Serum Albumin - metabolism sodium chloride Sodium Chloride - therapeutic use urethra urethral obstruction Urethral Obstruction - drug therapy Urethral Obstruction - physiopathology Urethral Obstruction - veterinary urinary tract diseases |
title | Renal and cardiorespiratory effects of treatment with lactated Ringer's solution or physiologic saline (0.9% NaCl) solution in cats with experimentally induced urethral obstruction |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T16%3A04%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Renal%20and%20cardiorespiratory%20effects%20of%20treatment%20with%20lactated%20Ringer's%20solution%20or%20physiologic%20saline%20(0.9%25%20NaCl)%20solution%20in%20cats%20with%20experimentally%20induced%20urethral%20obstruction&rft.jtitle=American%20journal%20of%20veterinary%20research&rft.au=Cunha,%20Marina%20G.M.C.M&rft.date=2010-07-01&rft.volume=71&rft.issue=7&rft.spage=840&rft.epage=846&rft.pages=840-846&rft.issn=0002-9645&rft.eissn=1943-5681&rft_id=info:doi/10.2460/ajvr.71.7.840&rft_dat=%3Cproquest_cross%3E733627263%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733627263&rft_id=info:pmid/20594088&rfr_iscdi=true |