Monodispersed DOTA-PEG-conjugated anti-TAG-72 diabody has low kidney uptake and high tumor-to-blood ratios resulting in improved 64Cu PET

Diabodies are noncovalent dimers of single-chain antibody fragments that retain the avidity of intact IgG but have more favorable blood clearance than intact IgG. Radiometals offer a wide range of half-lives and emissions for matching imaging and therapy requirements and provide facile labeling of c...

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Veröffentlicht in:The Journal of nuclear medicine (1978) 2010-07, Vol.51 (7), p.1139
Hauptverfasser: Li, Lin, Turatti, Fabio, Crow, Desiree, Bading, James R, Anderson, Anne-Line, Poku, Erasmus, Yazaki, Paul J, Williams, Lawrence E, Tamvakis, Debra, Sanders, Paul, Leong, David, Raubitschek, Andrew, Hudson, Peter J, Colcher, David, Shively, John E
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Sprache:eng
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