$Randomized Study of Lapatinib Alone or in Combination With Trastuzumab in Women With ErbB2-Positive, Trastuzumab-Refractory Metastatic Breast Cancer$

Randomized Study of Lapatinib Alone or in Combination With Trastuzumab in Women With ErbB2-Positive, Trastuzumab-Refractory Metastatic Breast Cancer

Preclinical studies in ErbB2-positive cell lines demonstrated a synergistic interaction between lapatinib and trastuzumab, suggesting that dual blockade is more effective than a single agent alone. EGF104900 compared the activity of lapatinib alone or in combination with trastuzumab in patients with...

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Veröffentlicht in:	Journal of clinical oncology 2010-03, Vol.28 (7), p.1124-1130
Hauptverfasser:	BLACKWELL, Kimberly L, BURSTEIN, Harold J, BASELGA, Jose, O'SHAUGHNESSY, Joyce, STORNIOLO, Anna Maria, RUGO, Hope, SLEDGE, George, KOEHLER, Maria, ELLIS, Catherine, CASEY, Michelle, VUKELJA, Svetislava, BISCHOFF, Joachim
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal, Humanized Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Breast Neoplasms - drug therapy Breast Neoplasms - mortality Breast Neoplasms - pathology Disease-Free Survival Female Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Middle Aged Neoplasm Metastasis Quality of Life Quinazolines - administration & dosage Quinazolines - adverse effects Quinazolines - therapeutic use Receptor, ErbB-2 - analysis Stroke Volume - drug effects Trastuzumab Tumors Ventricular Function, Left - drug effects
Online-Zugang:	Volltext
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