Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet
In 2003, an international working group last reported on recommendations for diagnosis, response assessment, and treatment outcomes in acute myeloid leukemia (AML). Since that time, considerable progress has been made in elucidating the molecular pathogenesis of the disease that has resulted in the...
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| Veröffentlicht in: | Blood 2010-01, Vol.115 (3), p.453-474 |
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| creator | Döhner, Hartmut Estey, Elihu H. Amadori, Sergio Appelbaum, Frederick R. Büchner, Thomas Burnett, Alan K. Dombret, Hervé Fenaux, Pierre Grimwade, David Larson, Richard A. Lo-Coco, Francesco Naoe, Tomoki Niederwieser, Dietger Ossenkoppele, Gert J. Sanz, Miguel A. Sierra, Jorge Tallman, Martin S. Löwenberg, Bob Bloomfield, Clara D. |
| description | In 2003, an international working group last reported on recommendations for diagnosis, response assessment, and treatment outcomes in acute myeloid leukemia (AML). Since that time, considerable progress has been made in elucidating the molecular pathogenesis of the disease that has resulted in the identification of new diagnostic and prognostic markers. Furthermore, therapies are now being developed that target disease-associated molecular defects. Recent developments prompted an international expert panel to provide updated evidence- and expert opinion–based recommendations for the diagnosis and management of AML, that contain both minimal requirements for general practice as well as standards for clinical trials. A new standardized reporting system for correlation of cytogenetic and molecular genetic data with clinical data is proposed. |
| doi_str_mv | 10.1182/blood-2009-07-235358 |
| format | Article |
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Since that time, considerable progress has been made in elucidating the molecular pathogenesis of the disease that has resulted in the identification of new diagnostic and prognostic markers. Furthermore, therapies are now being developed that target disease-associated molecular defects. Recent developments prompted an international expert panel to provide updated evidence- and expert opinion–based recommendations for the diagnosis and management of AML, that contain both minimal requirements for general practice as well as standards for clinical trials. A new standardized reporting system for correlation of cytogenetic and molecular genetic data with clinical data is proposed.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood-2009-07-235358</identifier><identifier>PMID: 19880497</identifier><language>eng</language><publisher>Washington, DC: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Age Factors ; Biological and medical sciences ; Health Planning Guidelines ; Hematologic and hematopoietic diseases ; Humans ; International Cooperation ; Leukemia, Myeloid, Acute - diagnosis ; Leukemia, Myeloid, Acute - etiology ; Leukemia, Myeloid, Acute - therapy ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Medical sciences ; Middle Aged ; Prognosis ; Risk Factors ; Young Adult</subject><ispartof>Blood, 2010-01, Vol.115 (3), p.453-474</ispartof><rights>2010 American Society of Hematology</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-641ce4ea6c70d5062faa55abf4425baeadff3e3b0cd1925f64bd6a0b8de4aced3</citedby><cites>FETCH-LOGICAL-c503t-641ce4ea6c70d5062faa55abf4425baeadff3e3b0cd1925f64bd6a0b8de4aced3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22327199$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19880497$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Döhner, Hartmut</creatorcontrib><creatorcontrib>Estey, Elihu H.</creatorcontrib><creatorcontrib>Amadori, Sergio</creatorcontrib><creatorcontrib>Appelbaum, Frederick R.</creatorcontrib><creatorcontrib>Büchner, Thomas</creatorcontrib><creatorcontrib>Burnett, Alan K.</creatorcontrib><creatorcontrib>Dombret, Hervé</creatorcontrib><creatorcontrib>Fenaux, Pierre</creatorcontrib><creatorcontrib>Grimwade, David</creatorcontrib><creatorcontrib>Larson, Richard A.</creatorcontrib><creatorcontrib>Lo-Coco, Francesco</creatorcontrib><creatorcontrib>Naoe, Tomoki</creatorcontrib><creatorcontrib>Niederwieser, Dietger</creatorcontrib><creatorcontrib>Ossenkoppele, Gert J.</creatorcontrib><creatorcontrib>Sanz, Miguel A.</creatorcontrib><creatorcontrib>Sierra, Jorge</creatorcontrib><creatorcontrib>Tallman, Martin S.</creatorcontrib><creatorcontrib>Löwenberg, Bob</creatorcontrib><creatorcontrib>Bloomfield, Clara D.</creatorcontrib><creatorcontrib>European LeukemiaNet</creatorcontrib><title>Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet</title><title>Blood</title><addtitle>Blood</addtitle><description>In 2003, an international working group last reported on recommendations for diagnosis, response assessment, and treatment outcomes in acute myeloid leukemia (AML). Since that time, considerable progress has been made in elucidating the molecular pathogenesis of the disease that has resulted in the identification of new diagnostic and prognostic markers. Furthermore, therapies are now being developed that target disease-associated molecular defects. Recent developments prompted an international expert panel to provide updated evidence- and expert opinion–based recommendations for the diagnosis and management of AML, that contain both minimal requirements for general practice as well as standards for clinical trials. A new standardized reporting system for correlation of cytogenetic and molecular genetic data with clinical data is proposed.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Health Planning Guidelines</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>International Cooperation</subject><subject>Leukemia, Myeloid, Acute - diagnosis</subject><subject>Leukemia, Myeloid, Acute - etiology</subject><subject>Leukemia, Myeloid, Acute - therapy</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>Young Adult</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUuPFCEUhYnROO3oPzCGjXFjKY-iHi5MzDg-ko5udE1uwWUGrYIWKOP8Ev-u9HRFd65I4Dv3XM4h5DFnLzgfxMtpjtE2grGxYX0jpJJquEN2XImhYUywu2THGOuaduz5GXmQ8zfGeCuFuk_O-DgMrD7syO-3Hq5CzD5TCJYuEOAKFwyFRkfBrAXpcoNz9JbOuH7HxQP1gYJd55Jf0YQmLhW3UHwMmboUlzqoIgVTuL2EmeKvA6ZCDxBwfk5joBNew-yOFuUa6eWa4gGrar85fMLykNxzMGd8tJ3n5Ou7yy8XH5r95_cfL97sG6OYLE3XcoMtQmd6ZhXrhANQCibXtkJNgGCdkygnZiwfhXJdO9kO2DRYbMGglefk2WnuIcUfK-aiF58NznPdNa5Z91J2okY1VLI9kSbFnBM6fUh-gXSjOdPHRvRtI_rYiGa9PjVSZU82g3Va0P4TbRVU4OkGQDY1lQTB-PyXE0KKno9j5V6fOKxx_PSYdDYeQ_2Ery0UbaP__yZ_APL7rog</recordid><startdate>20100121</startdate><enddate>20100121</enddate><creator>Döhner, Hartmut</creator><creator>Estey, Elihu H.</creator><creator>Amadori, Sergio</creator><creator>Appelbaum, Frederick R.</creator><creator>Büchner, Thomas</creator><creator>Burnett, Alan K.</creator><creator>Dombret, Hervé</creator><creator>Fenaux, Pierre</creator><creator>Grimwade, David</creator><creator>Larson, Richard A.</creator><creator>Lo-Coco, Francesco</creator><creator>Naoe, Tomoki</creator><creator>Niederwieser, Dietger</creator><creator>Ossenkoppele, Gert J.</creator><creator>Sanz, Miguel A.</creator><creator>Sierra, Jorge</creator><creator>Tallman, Martin S.</creator><creator>Löwenberg, Bob</creator><creator>Bloomfield, Clara D.</creator><general>Elsevier Inc</general><general>Americain Society of Hematology</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100121</creationdate><title>Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet</title><author>Döhner, Hartmut ; Estey, Elihu H. ; Amadori, Sergio ; Appelbaum, Frederick R. ; Büchner, Thomas ; Burnett, Alan K. ; Dombret, Hervé ; Fenaux, Pierre ; Grimwade, David ; Larson, Richard A. ; Lo-Coco, Francesco ; Naoe, Tomoki ; Niederwieser, Dietger ; Ossenkoppele, Gert J. ; Sanz, Miguel A. ; Sierra, Jorge ; Tallman, Martin S. ; Löwenberg, Bob ; Bloomfield, Clara D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-641ce4ea6c70d5062faa55abf4425baeadff3e3b0cd1925f64bd6a0b8de4aced3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Health Planning Guidelines</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>International Cooperation</topic><topic>Leukemia, Myeloid, Acute - diagnosis</topic><topic>Leukemia, Myeloid, Acute - etiology</topic><topic>Leukemia, Myeloid, Acute - therapy</topic><topic>Leukemias. 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| ispartof | Blood, 2010-01, Vol.115 (3), p.453-474 |
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| subjects | Adolescent Adult Age Factors Biological and medical sciences Health Planning Guidelines Hematologic and hematopoietic diseases Humans International Cooperation Leukemia, Myeloid, Acute - diagnosis Leukemia, Myeloid, Acute - etiology Leukemia, Myeloid, Acute - therapy Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Middle Aged Prognosis Risk Factors Young Adult |
| title | Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet |
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