Long-Term Engraftment of Fresh Human Myeloma Cells in SCID Mice

Using highly purified myeloma cells from patient bone marrow, we established human-murine myeloma chimeras in severe combined immunodeficiency (SCID) mice and documented secretion of monoclonal human immunoglobulins (HuIgs) in the mice for up to 299 days. Monoclonality of circulating HuIgs was found...

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Veröffentlicht in:	Blood 1992-12, Vol.80 (11), p.2843-2850
Hauptverfasser:	Feo-Zuppardi, Francisco J., Taylor, Charles W., Iwato, Koji, Lopez, Marialouisa H.A., Grogan, Thomas M., Odeleye, Abiodun, Hersh, Evan M., Salmon, Sydney E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animal tumors. Experimental tumors Animals Biological and medical sciences Enzyme-Linked Immunosorbent Assay Experimental malignant blood diseases Female Humans Immunoenzyme Techniques Immunoglobulin G - analysis Immunoglobulin kappa-Chains - analysis Immunoglobulin Light Chains - analysis Male Medical sciences Mice Mice, SCID Middle Aged Multiple Myeloma - immunology Multiple Myeloma - pathology Neoplasm Staging Neoplasm Transplantation Transplantation, Heterologous Tumors
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