Dimerization is essential for 14-3-3zeta stability and function in vivo

Members of the conserved 14-3-3 protein family spontaneously self-assemble as homo- and heterodimers via conserved sequences in the first four (alphaA-alphaD) of the nine helices that comprise them. Dimeric 14-3-3s bind conserved motifs in diverse protein targets involved in multiple essential cellu...

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Veröffentlicht in:	The Journal of biological chemistry 2010-01, Vol.285 (3), p.1692-1700
Hauptverfasser:	Messaritou, Georgia, Grammenoudi, Sofia, Skoulakis, Efthimios M C
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins - chemistry 14-3-3 Proteins - genetics 14-3-3 Proteins - metabolism Animals Conserved Sequence Drosophila melanogaster Drosophila Proteins - chemistry Drosophila Proteins - genetics Drosophila Proteins - metabolism Homeostasis Mutation Protein Multimerization Protein Stability Protein Structure, Quaternary
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