Kidney function and future risk for adverse pregnancy outcomes: a population-based study from HUNT II, Norway

Background. Current knowledge on prepregnancy reduced kidney function and the risk of adverse pregnancy outcomes mainly relies on small studies in selected populations. We aim to investigate whether reduced kidney function is associated with the risk of adverse pregnancy-related outcomes in the general population. Methods. A population-based study linking all women attending the Second Health Study in Nord-Trøndelag, Norway (1995–97) and subsequent pregnancies registered in the Medical Birth Registry. Multivariable random-effect logistic regression analysis was used to explore the association between renal function and study outcome. Results. The mean eGFR among 3405 women was 107.6 ± 19.4 ml/min/1.73 m2 at baseline; 18.8% and 0.1% had eGFR of 60–89 and