Immunization against hepatitis C virus with a fusion protein containing the extra domain A from fibronectin and the hepatitis C virus NS3 protein

Background/Aims Vaccination strategies able to induce strong T-cell responses might contribute to eradicate hepatitis C virus (HCV) infection. We previously demonstrated that fusion of an antigen to the extra domain A from fibronectin (EDA) targets the antigen to TLR4-expressing dendritic cells (DC)...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of hepatology 2009-09, Vol.51 (3), p.520-527
Hauptverfasser:	Mansilla, Cristina, Gorraiz, Marta, Martinez, Marta, Casares, Noelia, Arribillaga, Laura, Rudilla, Francesc, Echeverria, Iciar, Riezu-Boj, José Ignacio, Sarobe, Pablo, Borrás-Cuesta, Francisco, Prieto, Jesús, Lasarte, Juan José
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Animals Antiviral Agents - therapeutic use Biological and medical sciences Cell Line Cells, Cultured Dendritic cell Dendritic Cells - cytology Dendritic Cells - metabolism Disease Models, Animal Drug Therapy, Combination EDA Escherichia coli - metabolism Female Fibronectins - biosynthesis Fibronectins - therapeutic use Gastroenterology and Hepatology Gastroenterology. Liver. Pancreas. Abdomen Hepacivirus - genetics Hepacivirus - immunology Hepacivirus - metabolism Hepatitis C Hepatitis C - immunology Hepatitis C - metabolism Hepatitis C - prevention & control HLA-A2 Antigen - genetics HLA-A2 Antigen - immunology HLA-A2 Antigen - metabolism Human viral diseases Humans Infectious diseases Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Poly I-C - therapeutic use Protein Structure, Tertiary Recombinant Proteins - biosynthesis Recombinant Proteins - therapeutic use RNA, Viral - metabolism Vaccine Viral diseases Viral Fusion Proteins - biosynthesis Viral Fusion Proteins - therapeutic use Viral hepatitis Viral Nonstructural Proteins - biosynthesis Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - therapeutic use Viral Vaccines - biosynthesis Viral Vaccines - therapeutic use
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!