Beyond symptom dimensions: Schizophrenia risk factors for patient groups derived by latent class analysis
Abstract Introduction: Patients grouped by latent class analysis of symptoms show some consensus between studies, and may be less etiologically heterogeneous than current diagnoses. If so, the effect size of ‘neurodevelopmental’ risk factors may be greater than in equivalent DSMIV diagnostic groups....
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| Veröffentlicht in: | Schizophrenia research 2009-12, Vol.115 (2), p.346-350 |
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| container_title | Schizophrenia research |
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| creator | Leask, S.J Vermunt, J.K Done, D.J Crow, T.J Blows, M Boks, M.P |
| description | Abstract Introduction: Patients grouped by latent class analysis of symptoms show some consensus between studies, and may be less etiologically heterogeneous than current diagnoses. If so, the effect size of ‘neurodevelopmental’ risk factors may be greater than in equivalent DSMIV diagnostic groups. Method: Two hundred fifty six individuals with neurodevelopmental risk factors recorded in the National Child Development Study (1958) UK birth cohort were grouped by data-driven illness subtypes, derived previously in over 1000 individuals. The effect sizes of these risks were compared between data-derived and DSMIV schizophrenia (295.x) groups. Results: Compared to DSMIV schizophrenia, the data-driven subtype broadly characterized by the presence of psychotic symptoms in the absence of affective symptoms showed significantly greater effect sizes in eight out of thirteen continuously-rated risk factors: birth weight, cognition, childhood behavioural problems, and neurological softsigns including handedness. Conclusion: A data-driven subgroup of schizophrenia patients, characterized as lacking co-morbid depressive symptoms, is less heterogeneous with respect to neurodevelopmental etiology. |
| doi_str_mv | 10.1016/j.schres.2009.09.017 |
| format | Article |
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If so, the effect size of ‘neurodevelopmental’ risk factors may be greater than in equivalent DSMIV diagnostic groups. Method: Two hundred fifty six individuals with neurodevelopmental risk factors recorded in the National Child Development Study (1958) UK birth cohort were grouped by data-driven illness subtypes, derived previously in over 1000 individuals. The effect sizes of these risks were compared between data-derived and DSMIV schizophrenia (295.x) groups. Results: Compared to DSMIV schizophrenia, the data-driven subtype broadly characterized by the presence of psychotic symptoms in the absence of affective symptoms showed significantly greater effect sizes in eight out of thirteen continuously-rated risk factors: birth weight, cognition, childhood behavioural problems, and neurological softsigns including handedness. Conclusion: A data-driven subgroup of schizophrenia patients, characterized as lacking co-morbid depressive symptoms, is less heterogeneous with respect to neurodevelopmental etiology.</description><identifier>ISSN: 0920-9964</identifier><identifier>EISSN: 1573-2509</identifier><identifier>DOI: 10.1016/j.schres.2009.09.017</identifier><identifier>PMID: 19840897</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adult and adolescent clinical studies ; Analysis of Variance ; Biological and medical sciences ; Child ; Cohort Studies ; Factor Analysis, Statistical ; Female ; Genetics ; Humans ; Male ; Medical sciences ; Netherlands - epidemiology ; Neurodevelopment ; Personality Assessment ; Psychiatric Status Rating Scales ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Psychosis ; Retrospective Studies ; Risk Factors ; Schizophrenia ; Schizophrenia - diagnosis ; Schizophrenia - etiology ; Schizophrenia - physiopathology ; Schizophrenic Psychology ; Symptom dimensions</subject><ispartof>Schizophrenia research, 2009-12, Vol.115 (2), p.346-350</ispartof><rights>2009</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-3269e0fa22e2c69b9e215d5c15f9e4f0121bbc662d6e17a432623bbcc638583f3</citedby><cites>FETCH-LOGICAL-c446t-3269e0fa22e2c69b9e215d5c15f9e4f0121bbc662d6e17a432623bbcc638583f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0920996409004368$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22199839$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19840897$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leask, S.J</creatorcontrib><creatorcontrib>Vermunt, J.K</creatorcontrib><creatorcontrib>Done, D.J</creatorcontrib><creatorcontrib>Crow, T.J</creatorcontrib><creatorcontrib>Blows, M</creatorcontrib><creatorcontrib>Boks, M.P</creatorcontrib><title>Beyond symptom dimensions: Schizophrenia risk factors for patient groups derived by latent class analysis</title><title>Schizophrenia research</title><addtitle>Schizophr Res</addtitle><description>Abstract Introduction: Patients grouped by latent class analysis of symptoms show some consensus between studies, and may be less etiologically heterogeneous than current diagnoses. If so, the effect size of ‘neurodevelopmental’ risk factors may be greater than in equivalent DSMIV diagnostic groups. Method: Two hundred fifty six individuals with neurodevelopmental risk factors recorded in the National Child Development Study (1958) UK birth cohort were grouped by data-driven illness subtypes, derived previously in over 1000 individuals. The effect sizes of these risks were compared between data-derived and DSMIV schizophrenia (295.x) groups. Results: Compared to DSMIV schizophrenia, the data-driven subtype broadly characterized by the presence of psychotic symptoms in the absence of affective symptoms showed significantly greater effect sizes in eight out of thirteen continuously-rated risk factors: birth weight, cognition, childhood behavioural problems, and neurological softsigns including handedness. Conclusion: A data-driven subgroup of schizophrenia patients, characterized as lacking co-morbid depressive symptoms, is less heterogeneous with respect to neurodevelopmental etiology.</description><subject>Adult and adolescent clinical studies</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Cohort Studies</subject><subject>Factor Analysis, Statistical</subject><subject>Female</subject><subject>Genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Netherlands - epidemiology</subject><subject>Neurodevelopment</subject><subject>Personality Assessment</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Psychosis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - etiology</subject><subject>Schizophrenia - physiopathology</subject><subject>Schizophrenic Psychology</subject><subject>Symptom dimensions</subject><issn>0920-9964</issn><issn>1573-2509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl2L1TAQhoMo7nH1H4jkRrzqMZO0aeOFoItfsODF6nXISaduzrZNzbQL9debcg4K3ggDgeSZecPDMPYcxB4E6NfHPfnbhLSXQpj9VlA_YDuoalXISpiHbCeMFIUxurxgT4iOQgioRP2YXYBpStGYesfCe1zj2HJah2mOA2_DgCOFONIbfuNvw6845ZAxOJ4C3fHO-Tkm4l1MfHJzwHHmP1JcJuItpnCPLT-svHfz9uB7R8Td6PqVAj1ljzrXEz47n5fs-8cP364-F9dfP325endd-LLUc6GkNig6JyVKr83BoISqrTxUncGyEyDhcPBay1Yj1K7MvFT5xmvVVI3q1CV7dZo7pfhzQZrtEMhj37sR40K2VkpDqQAyWZ5InyJRws5OKQwurRaE3Rzboz05tptjuxXUue3FOWA5DNj-bTpLzcDLM-DIu75LbvSB_nBSgjGNMpl7e-Iw67gPmHJaNuqxDQn9bNsY_veTfwf4PowhZ97hinSMS8ryyYIlaYW92fZhWwdhhCiVbtRvmhyyzw</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Leask, S.J</creator><creator>Vermunt, J.K</creator><creator>Done, D.J</creator><creator>Crow, T.J</creator><creator>Blows, M</creator><creator>Boks, M.P</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091201</creationdate><title>Beyond symptom dimensions: Schizophrenia risk factors for patient groups derived by latent class analysis</title><author>Leask, S.J ; Vermunt, J.K ; Done, D.J ; Crow, T.J ; Blows, M ; Boks, M.P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-3269e0fa22e2c69b9e215d5c15f9e4f0121bbc662d6e17a432623bbcc638583f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Cohort Studies</topic><topic>Factor Analysis, Statistical</topic><topic>Female</topic><topic>Genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Netherlands - epidemiology</topic><topic>Neurodevelopment</topic><topic>Personality Assessment</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Psychosis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - etiology</topic><topic>Schizophrenia - physiopathology</topic><topic>Schizophrenic Psychology</topic><topic>Symptom dimensions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leask, S.J</creatorcontrib><creatorcontrib>Vermunt, J.K</creatorcontrib><creatorcontrib>Done, D.J</creatorcontrib><creatorcontrib>Crow, T.J</creatorcontrib><creatorcontrib>Blows, M</creatorcontrib><creatorcontrib>Boks, M.P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Schizophrenia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leask, S.J</au><au>Vermunt, J.K</au><au>Done, D.J</au><au>Crow, T.J</au><au>Blows, M</au><au>Boks, M.P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beyond symptom dimensions: Schizophrenia risk factors for patient groups derived by latent class analysis</atitle><jtitle>Schizophrenia research</jtitle><addtitle>Schizophr Res</addtitle><date>2009-12-01</date><risdate>2009</risdate><volume>115</volume><issue>2</issue><spage>346</spage><epage>350</epage><pages>346-350</pages><issn>0920-9964</issn><eissn>1573-2509</eissn><abstract>Abstract Introduction: Patients grouped by latent class analysis of symptoms show some consensus between studies, and may be less etiologically heterogeneous than current diagnoses. If so, the effect size of ‘neurodevelopmental’ risk factors may be greater than in equivalent DSMIV diagnostic groups. Method: Two hundred fifty six individuals with neurodevelopmental risk factors recorded in the National Child Development Study (1958) UK birth cohort were grouped by data-driven illness subtypes, derived previously in over 1000 individuals. The effect sizes of these risks were compared between data-derived and DSMIV schizophrenia (295.x) groups. Results: Compared to DSMIV schizophrenia, the data-driven subtype broadly characterized by the presence of psychotic symptoms in the absence of affective symptoms showed significantly greater effect sizes in eight out of thirteen continuously-rated risk factors: birth weight, cognition, childhood behavioural problems, and neurological softsigns including handedness. 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| subjects | Adult and adolescent clinical studies Analysis of Variance Biological and medical sciences Child Cohort Studies Factor Analysis, Statistical Female Genetics Humans Male Medical sciences Netherlands - epidemiology Neurodevelopment Personality Assessment Psychiatric Status Rating Scales Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Psychosis Retrospective Studies Risk Factors Schizophrenia Schizophrenia - diagnosis Schizophrenia - etiology Schizophrenia - physiopathology Schizophrenic Psychology Symptom dimensions |
| title | Beyond symptom dimensions: Schizophrenia risk factors for patient groups derived by latent class analysis |
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