Reduced cerebrospinal fluid and plasma nerve growth factor in drug-naïve psychotic patients
Abstract Impaired expression and function of several major neurotrophic factors such as nerve growth factor (NGF) has been proposed to contribute to the neurodevelopmental pathology of schizophrenia. However, the evidence in the majority of studies is based on variable and inconsistent levels of pla...
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| Veröffentlicht in: | Schizophrenia research 2009-12, Vol.115 (2), p.209-214 |
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| container_title | Schizophrenia research |
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| creator | Kale, Anvita Joshi, Sadhana Pillai, Anilkumar Naphade, Nilesh Raju, MSVK Nasrallah, Henry Mahadik, Sahebarao P |
| description | Abstract Impaired expression and function of several major neurotrophic factors such as nerve growth factor (NGF) has been proposed to contribute to the neurodevelopmental pathology of schizophrenia. However, the evidence in the majority of studies is based on variable and inconsistent levels of plasma NGF in diverse populations of early psychosis or medicated patients with chronic schizophrenia. We report here the first study comparing NGF levels in cerebrospinal fluid (CSF) and plasma from a unique patient cohort (unmedicated, early psychotic patients with similar racial and dietary patterns) and matched healthy controls. Significantly lower levels of NGF in both CSF ( p = 0.038) and plasma ( p = 0.002) were observed in drug-naïve first-episode psychosis patients as compared to controls. The levels of NGF in the CSF correlated ( p = 0.05) to the plasma values in controls. The data on plasma NGF confirm the reported deficits of NGF in drug-naïve first-episode psychosis. The reduced levels first time observed here may have important implications to repeatedly reported neurobiological and clinical deficits which are discussed. |
| doi_str_mv | 10.1016/j.schres.2009.07.022 |
| format | Article |
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However, the evidence in the majority of studies is based on variable and inconsistent levels of plasma NGF in diverse populations of early psychosis or medicated patients with chronic schizophrenia. We report here the first study comparing NGF levels in cerebrospinal fluid (CSF) and plasma from a unique patient cohort (unmedicated, early psychotic patients with similar racial and dietary patterns) and matched healthy controls. Significantly lower levels of NGF in both CSF ( p = 0.038) and plasma ( p = 0.002) were observed in drug-naïve first-episode psychosis patients as compared to controls. The levels of NGF in the CSF correlated ( p = 0.05) to the plasma values in controls. The data on plasma NGF confirm the reported deficits of NGF in drug-naïve first-episode psychosis. The reduced levels first time observed here may have important implications to repeatedly reported neurobiological and clinical deficits which are discussed.</description><identifier>ISSN: 0920-9964</identifier><identifier>EISSN: 1573-2509</identifier><identifier>DOI: 10.1016/j.schres.2009.07.022</identifier><identifier>PMID: 19713082</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; Case-Control Studies ; Cerebrospinal fluid ; Double-Blind Method ; Female ; Follow-Up Studies ; Humans ; Male ; Medical sciences ; Nerve growth factor ; Nerve Growth Factor - blood ; Nerve Growth Factor - cerebrospinal fluid ; Psychiatric Status Rating Scales ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. 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However, the evidence in the majority of studies is based on variable and inconsistent levels of plasma NGF in diverse populations of early psychosis or medicated patients with chronic schizophrenia. We report here the first study comparing NGF levels in cerebrospinal fluid (CSF) and plasma from a unique patient cohort (unmedicated, early psychotic patients with similar racial and dietary patterns) and matched healthy controls. Significantly lower levels of NGF in both CSF ( p = 0.038) and plasma ( p = 0.002) were observed in drug-naïve first-episode psychosis patients as compared to controls. The levels of NGF in the CSF correlated ( p = 0.05) to the plasma values in controls. The data on plasma NGF confirm the reported deficits of NGF in drug-naïve first-episode psychosis. The reduced levels first time observed here may have important implications to repeatedly reported neurobiological and clinical deficits which are discussed.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Cerebrospinal fluid</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nerve growth factor</subject><subject>Nerve Growth Factor - blood</subject><subject>Nerve Growth Factor - cerebrospinal fluid</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Psychotic Disorders - blood</subject><subject>Psychotic Disorders - cerebrospinal fluid</subject><subject>Schizophrenia</subject><subject>Statistics as Topic</subject><subject>Young Adult</subject><issn>0920-9964</issn><issn>1573-2509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks2KFDEQgIMo7rj6BiK5iKduK5VOZ3IRZFl_YEHw5yaETLqyk7Gnu026V-apfAhfzAwzKHjxlEO--vuqGHsqoBYg2pe7OvttolwjgKlB14B4j62E0rJCBeY-W4FBqIxpmwv2KOcdAAgF-iG7EEYLCWtcsa8fqVs8ddxTok0a8xQH1_PQL7Hjbuj41Lu8d3ygdEf8No0_5i0Pzs9j4nHgXVpuq8H9-lk-p3zw23GOnk9ujjTM-TF7EFyf6cn5vWRf3lx_vnpX3Xx4-_7q9U3llcC56pwSDttmo0K7RrkRRnRrHTQ2jQ6lVWxBoFYeUUs0wUmvwIHXhRIBhZKX7MUp75TG7wvl2e5j9tT3bqBxyVZL2YoGjSlkcyJ9GTUnCnZKce_SwQqwR612Z09a7VGrBW2L1hL27Fxg2eyp-xt09liA52fAZe_6kNzgY_7DIQpj1giFe3XiqOi4i5RKtaKqLCAm8rPtxvi_Tv5N4Ps4xFLzGx0o78Yllf1lK2xGC_bT8QSOFwAGQEqt5G_MsazV</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Kale, Anvita</creator><creator>Joshi, Sadhana</creator><creator>Pillai, Anilkumar</creator><creator>Naphade, Nilesh</creator><creator>Raju, MSVK</creator><creator>Nasrallah, Henry</creator><creator>Mahadik, Sahebarao P</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091201</creationdate><title>Reduced cerebrospinal fluid and plasma nerve growth factor in drug-naïve psychotic patients</title><author>Kale, Anvita ; Joshi, Sadhana ; Pillai, Anilkumar ; Naphade, Nilesh ; Raju, MSVK ; Nasrallah, Henry ; Mahadik, Sahebarao P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-da51a264b5f6823b191d87f72447f1972601275c227329fa3c50a0c71d81f2153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Cerebrospinal fluid</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nerve growth factor</topic><topic>Nerve Growth Factor - blood</topic><topic>Nerve Growth Factor - cerebrospinal fluid</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. 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| subjects | Adolescent Adult Adult and adolescent clinical studies Biological and medical sciences Case-Control Studies Cerebrospinal fluid Double-Blind Method Female Follow-Up Studies Humans Male Medical sciences Nerve growth factor Nerve Growth Factor - blood Nerve Growth Factor - cerebrospinal fluid Psychiatric Status Rating Scales Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Psychotic Disorders - blood Psychotic Disorders - cerebrospinal fluid Schizophrenia Statistics as Topic Young Adult |
| title | Reduced cerebrospinal fluid and plasma nerve growth factor in drug-naïve psychotic patients |
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