Donepezil- and scopolamine-induced rCMRglu changes assessed by PET in conscious rhesus monkeys
Objective [ 18 F]Fluoro-2-deoxyglucose positron emission tomography (FDG-PET) is a useful tool for measuring the regional cerebral metabolic rate of glucose (rCMRglu), which is an index of neuronal activity. Donepezil, an acetylcholine esterase inhibitor (AChEI), has been recommended as a treatment...
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| Veröffentlicht in: | Annals of nuclear medicine 2009-12, Vol.23 (10), p.877-882 |
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| container_title | Annals of nuclear medicine |
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| creator | Asai, Makoto Fujikawa, Akihiko Noda, Akihiro Miyoshi, Sosuke Matsuoka, Nobuya Nishimura, Shintaro |
| description | Objective
[
18
F]Fluoro-2-deoxyglucose positron emission tomography (FDG-PET) is a useful tool for measuring the regional cerebral metabolic rate of glucose (rCMRglu), which is an index of neuronal activity. Donepezil, an acetylcholine esterase inhibitor (AChEI), has been recommended as a treatment option for patients with Alzheimer’s disease (AD). We aimed to characterize the effects of donepezil on rCMRglu using FDG-PET in non-human primates.
Methods
We investigated the effects of administration of donepezil (500 μg/kg, i.m.), the non-selective muscarinic ACh receptor antagonist scopolamine (30 μg/kg, i.m.), and the coadministration of both drugs on the rCMRglu of conscious young rhesus monkeys.
Results
Donepezil increased the rCMRglu in all regions of interest except in the thalamus. Scopolamine treatment also increased the rCMRglu in all regions of interest except the cerebellum and thalamus. However, these effects disappeared with coadministration of the drugs.
Conclusions
This PET study showed that administration of donepezil or scopolamine alone increased the rCMRglu in conscious rhesus monkeys. We also found that the donepezil-induced increase was abolished by simultaneous administration of scopolamine, suggesting that muscarinic ACh receptor function plays an important role in the effect of donepezil. |
| doi_str_mv | 10.1007/s12149-009-0316-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733612469</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>21261083</sourcerecordid><originalsourceid>FETCH-LOGICAL-c454t-8c1a068790c507050fe1d61fc1139a97c69a01e02739a6cd60212b28c6cb84b93</originalsourceid><addsrcrecordid>eNp9kV1rHCEUhqW0JNtNfkBvivSivbI9Rx0_Lss2_YCUlpDcZnAcN5l0Rjeaudj--rrsQqCQgHIQH1-PPoS8QfiIAPpTQY7SMoA6BSqmX5AFGiWZkkK8JAuwKJlGo4_J61LuALhpDD8ix2gtl0LbBbn-kmLYhL_DyKiLPS0-bdLopiEGNsR-9qGnefXz4macqb918SYU6koJdfS029LfZ5d0iNSnWPyQ5kLzbSi1TCn-CdtyQl6t3VjC6aEuydXXs8vVd3b-69uP1edz5mUjH5jx6EAZbcE3oKGBdcBe4dojCuus9so6wABc16XyvQKOvOPGK98Z2VmxJB_2uZuc7udQHtppKD6Mo4uhdtVqIRRyqXbk-2fJGqwQjKjgu__AuzTnWF9RmQYkGrmDcA_5nErJYd1u8jC5vG0R2p2jdu-orY7anaPayZK8PQTP3RT6xxMHKRXge6DUrfrj-fHmp1P_AShQmr0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>215041843</pqid></control><display><type>article</type><title>Donepezil- and scopolamine-induced rCMRglu changes assessed by PET in conscious rhesus monkeys</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Asai, Makoto ; Fujikawa, Akihiko ; Noda, Akihiro ; Miyoshi, Sosuke ; Matsuoka, Nobuya ; Nishimura, Shintaro</creator><creatorcontrib>Asai, Makoto ; Fujikawa, Akihiko ; Noda, Akihiro ; Miyoshi, Sosuke ; Matsuoka, Nobuya ; Nishimura, Shintaro</creatorcontrib><description>Objective
[
18
F]Fluoro-2-deoxyglucose positron emission tomography (FDG-PET) is a useful tool for measuring the regional cerebral metabolic rate of glucose (rCMRglu), which is an index of neuronal activity. Donepezil, an acetylcholine esterase inhibitor (AChEI), has been recommended as a treatment option for patients with Alzheimer’s disease (AD). We aimed to characterize the effects of donepezil on rCMRglu using FDG-PET in non-human primates.
Methods
We investigated the effects of administration of donepezil (500 μg/kg, i.m.), the non-selective muscarinic ACh receptor antagonist scopolamine (30 μg/kg, i.m.), and the coadministration of both drugs on the rCMRglu of conscious young rhesus monkeys.
Results
Donepezil increased the rCMRglu in all regions of interest except in the thalamus. Scopolamine treatment also increased the rCMRglu in all regions of interest except the cerebellum and thalamus. However, these effects disappeared with coadministration of the drugs.
Conclusions
This PET study showed that administration of donepezil or scopolamine alone increased the rCMRglu in conscious rhesus monkeys. We also found that the donepezil-induced increase was abolished by simultaneous administration of scopolamine, suggesting that muscarinic ACh receptor function plays an important role in the effect of donepezil.</description><identifier>ISSN: 0914-7187</identifier><identifier>EISSN: 1864-6433</identifier><identifier>DOI: 10.1007/s12149-009-0316-7</identifier><identifier>PMID: 19924379</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Animals ; Brain - diagnostic imaging ; Brain - drug effects ; Brain - metabolism ; Cholinesterase Inhibitors - administration & dosage ; Cholinesterase Inhibitors - pharmacology ; Consciousness ; Drug Combinations ; Fluorodeoxyglucose F18 ; Glucose - metabolism ; Imaging ; Indans - administration & dosage ; Indans - pharmacology ; Macaca mulatta ; Male ; Medicine ; Medicine & Public Health ; Nuclear Medicine ; Original Article ; Piperidines - administration & dosage ; Piperidines - pharmacology ; Positron-Emission Tomography ; Primates ; Radiology ; Scopolamine Hydrobromide - administration & dosage ; Scopolamine Hydrobromide - pharmacology</subject><ispartof>Annals of nuclear medicine, 2009-12, Vol.23 (10), p.877-882</ispartof><rights>The Japanese Society of Nuclear Medicine 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-8c1a068790c507050fe1d61fc1139a97c69a01e02739a6cd60212b28c6cb84b93</citedby><cites>FETCH-LOGICAL-c454t-8c1a068790c507050fe1d61fc1139a97c69a01e02739a6cd60212b28c6cb84b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12149-009-0316-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12149-009-0316-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19924379$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Asai, Makoto</creatorcontrib><creatorcontrib>Fujikawa, Akihiko</creatorcontrib><creatorcontrib>Noda, Akihiro</creatorcontrib><creatorcontrib>Miyoshi, Sosuke</creatorcontrib><creatorcontrib>Matsuoka, Nobuya</creatorcontrib><creatorcontrib>Nishimura, Shintaro</creatorcontrib><title>Donepezil- and scopolamine-induced rCMRglu changes assessed by PET in conscious rhesus monkeys</title><title>Annals of nuclear medicine</title><addtitle>Ann Nucl Med</addtitle><addtitle>Ann Nucl Med</addtitle><description>Objective
[
18
F]Fluoro-2-deoxyglucose positron emission tomography (FDG-PET) is a useful tool for measuring the regional cerebral metabolic rate of glucose (rCMRglu), which is an index of neuronal activity. Donepezil, an acetylcholine esterase inhibitor (AChEI), has been recommended as a treatment option for patients with Alzheimer’s disease (AD). We aimed to characterize the effects of donepezil on rCMRglu using FDG-PET in non-human primates.
Methods
We investigated the effects of administration of donepezil (500 μg/kg, i.m.), the non-selective muscarinic ACh receptor antagonist scopolamine (30 μg/kg, i.m.), and the coadministration of both drugs on the rCMRglu of conscious young rhesus monkeys.
Results
Donepezil increased the rCMRglu in all regions of interest except in the thalamus. Scopolamine treatment also increased the rCMRglu in all regions of interest except the cerebellum and thalamus. However, these effects disappeared with coadministration of the drugs.
Conclusions
This PET study showed that administration of donepezil or scopolamine alone increased the rCMRglu in conscious rhesus monkeys. We also found that the donepezil-induced increase was abolished by simultaneous administration of scopolamine, suggesting that muscarinic ACh receptor function plays an important role in the effect of donepezil.</description><subject>Animals</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Cholinesterase Inhibitors - administration & dosage</subject><subject>Cholinesterase Inhibitors - pharmacology</subject><subject>Consciousness</subject><subject>Drug Combinations</subject><subject>Fluorodeoxyglucose F18</subject><subject>Glucose - metabolism</subject><subject>Imaging</subject><subject>Indans - administration & dosage</subject><subject>Indans - pharmacology</subject><subject>Macaca mulatta</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nuclear Medicine</subject><subject>Original Article</subject><subject>Piperidines - administration & dosage</subject><subject>Piperidines - pharmacology</subject><subject>Positron-Emission Tomography</subject><subject>Primates</subject><subject>Radiology</subject><subject>Scopolamine Hydrobromide - administration & dosage</subject><subject>Scopolamine Hydrobromide - pharmacology</subject><issn>0914-7187</issn><issn>1864-6433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kV1rHCEUhqW0JNtNfkBvivSivbI9Rx0_Lss2_YCUlpDcZnAcN5l0Rjeaudj--rrsQqCQgHIQH1-PPoS8QfiIAPpTQY7SMoA6BSqmX5AFGiWZkkK8JAuwKJlGo4_J61LuALhpDD8ix2gtl0LbBbn-kmLYhL_DyKiLPS0-bdLopiEGNsR-9qGnefXz4macqb918SYU6koJdfS029LfZ5d0iNSnWPyQ5kLzbSi1TCn-CdtyQl6t3VjC6aEuydXXs8vVd3b-69uP1edz5mUjH5jx6EAZbcE3oKGBdcBe4dojCuus9so6wABc16XyvQKOvOPGK98Z2VmxJB_2uZuc7udQHtppKD6Mo4uhdtVqIRRyqXbk-2fJGqwQjKjgu__AuzTnWF9RmQYkGrmDcA_5nErJYd1u8jC5vG0R2p2jdu-orY7anaPayZK8PQTP3RT6xxMHKRXge6DUrfrj-fHmp1P_AShQmr0</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Asai, Makoto</creator><creator>Fujikawa, Akihiko</creator><creator>Noda, Akihiro</creator><creator>Miyoshi, Sosuke</creator><creator>Matsuoka, Nobuya</creator><creator>Nishimura, Shintaro</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20091201</creationdate><title>Donepezil- and scopolamine-induced rCMRglu changes assessed by PET in conscious rhesus monkeys</title><author>Asai, Makoto ; Fujikawa, Akihiko ; Noda, Akihiro ; Miyoshi, Sosuke ; Matsuoka, Nobuya ; Nishimura, Shintaro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-8c1a068790c507050fe1d61fc1139a97c69a01e02739a6cd60212b28c6cb84b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Brain - 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Academic</collection><jtitle>Annals of nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asai, Makoto</au><au>Fujikawa, Akihiko</au><au>Noda, Akihiro</au><au>Miyoshi, Sosuke</au><au>Matsuoka, Nobuya</au><au>Nishimura, Shintaro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Donepezil- and scopolamine-induced rCMRglu changes assessed by PET in conscious rhesus monkeys</atitle><jtitle>Annals of nuclear medicine</jtitle><stitle>Ann Nucl Med</stitle><addtitle>Ann Nucl Med</addtitle><date>2009-12-01</date><risdate>2009</risdate><volume>23</volume><issue>10</issue><spage>877</spage><epage>882</epage><pages>877-882</pages><issn>0914-7187</issn><eissn>1864-6433</eissn><abstract>Objective
[
18
F]Fluoro-2-deoxyglucose positron emission tomography (FDG-PET) is a useful tool for measuring the regional cerebral metabolic rate of glucose (rCMRglu), which is an index of neuronal activity. Donepezil, an acetylcholine esterase inhibitor (AChEI), has been recommended as a treatment option for patients with Alzheimer’s disease (AD). We aimed to characterize the effects of donepezil on rCMRglu using FDG-PET in non-human primates.
Methods
We investigated the effects of administration of donepezil (500 μg/kg, i.m.), the non-selective muscarinic ACh receptor antagonist scopolamine (30 μg/kg, i.m.), and the coadministration of both drugs on the rCMRglu of conscious young rhesus monkeys.
Results
Donepezil increased the rCMRglu in all regions of interest except in the thalamus. Scopolamine treatment also increased the rCMRglu in all regions of interest except the cerebellum and thalamus. However, these effects disappeared with coadministration of the drugs.
Conclusions
This PET study showed that administration of donepezil or scopolamine alone increased the rCMRglu in conscious rhesus monkeys. We also found that the donepezil-induced increase was abolished by simultaneous administration of scopolamine, suggesting that muscarinic ACh receptor function plays an important role in the effect of donepezil.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>19924379</pmid><doi>10.1007/s12149-009-0316-7</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0914-7187 |
| ispartof | Annals of nuclear medicine, 2009-12, Vol.23 (10), p.877-882 |
| issn | 0914-7187 1864-6433 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Animals Brain - diagnostic imaging Brain - drug effects Brain - metabolism Cholinesterase Inhibitors - administration & dosage Cholinesterase Inhibitors - pharmacology Consciousness Drug Combinations Fluorodeoxyglucose F18 Glucose - metabolism Imaging Indans - administration & dosage Indans - pharmacology Macaca mulatta Male Medicine Medicine & Public Health Nuclear Medicine Original Article Piperidines - administration & dosage Piperidines - pharmacology Positron-Emission Tomography Primates Radiology Scopolamine Hydrobromide - administration & dosage Scopolamine Hydrobromide - pharmacology |
| title | Donepezil- and scopolamine-induced rCMRglu changes assessed by PET in conscious rhesus monkeys |
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