A selective, high affinity 5-HT 2B receptor antagonist inhibits visceral hypersensitivity in rats

RS-127445 is a selective, high affinity 5-HT(2B)receptor antagonist. We investigated whether 5-HT(2B)receptor antagonists can reduce colonic visceral hypersensitivity caused by restraint stress or by proximal colonic inflammation. Visceral hypersensitivity was induced in rats by either restraint str...

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Veröffentlicht in:	Neurogastroenterology and motility 2010-02, Vol.22 (2), p.e69-e76
Hauptverfasser:	Ohashi-Doi, K, Himaki, D, Nagao, K, Kawai, M, Gale, J D, Furness, J B, Kurebayashi, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Colon - drug effects Colon - pathology Colon - physiopathology Dose-Response Relationship, Drug Hypersensitivity - drug therapy Hypersensitivity - physiopathology Indoles - pharmacology Inflammation - pathology Inflammation - physiopathology Male Muscle Contraction - drug effects Muscle Contraction - physiology Muscle, Smooth - drug effects Muscle, Smooth - physiopathology Pain Measurement Pain Threshold - drug effects Pain Threshold - physiology Pyrimidines - pharmacology Rats Rats, Sprague-Dawley Receptor, Serotonin, 5-HT2B - physiology Restraint, Physical Serotonin 5-HT2 Receptor Antagonists Statistics, Nonparametric Stress, Physiological - physiology Trinitrobenzenesulfonic Acid - toxicity Urea - analogs & derivatives Urea - pharmacology
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