Influence of common variants near INSIG2, in FTO, and near MC4R genes on overweight and the metabolic profile in adolescence: the TRAILS (TRacking Adolescents' Individual Lives Survey) Study

BACKGROUND: Overweight is a complex trait in which both environmental and genetic factors play a role. OBJECTIVE: We aimed to evaluate the influence of common genetic variants identified by genome-wide association studies on overweight and the metabolic profile in adolescence. DESIGN: In a populatio...

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Veröffentlicht in:	The American journal of clinical nutrition 2010-02, Vol.91 (2), p.321-328
Hauptverfasser:	Liem, Eryn T, Vonk, Judith M, Sauer, Pieter JJ, van der Steege, Gerrit, Oosterom, Elvira, Stolk, Ronald P, Snieder, Harold
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent adolescent nutrition adolescents Alpha-Ketoglutarate-Dependent Dioxygenase FTO anthropometric measurements Biological and medical sciences blood glucose Blood Glucose - analysis blood lipids blood pressure Blood Pressure - physiology body composition Body Composition - physiology Body Mass Index body weight boys Child development Cohort Studies DNA DNA - chemistry DNA - genetics Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology gender differences Genes Genetic Variation Genetics Genotype girls height human diseases Humans insulin Insulin - blood Intracellular Signaling Peptides and Proteins - genetics Lipids - blood longitudinal studies Male Membrane Proteins - genetics Metabolism metabolome nutritional status Obesity overweight Overweight - blood Overweight - genetics Overweight - metabolism Polymorphism, Single Nucleotide Prospective Studies Proteins - genetics Receptor, Melanocortin, Type 4 - genetics Regression analysis single nucleotide polymorphism skinfold thickness Vertebrates: anatomy and physiology, studies on body, several organs or systems waist circumference Waist Circumference - physiology
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