The JAK2 46/1 haplotype confers susceptibility to essential thrombocythemia regardless of JAK2V617F mutational status—clinical correlates in a study of 226 consecutive patients

The germline JAK2 haplotype 46/1, tagged by the ‘C’ allele of single-nucleotide polymorphism (SNP) rs12343867 (C/T), has been associated with JAK2 V617F (VF)-positive myeloproliferative neoplasms. SNP rs12343867 was genotyped using bone marrow DNA in 226 consecutive patients with essential thrombocy...

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Veröffentlicht in:	Leukemia 2010-01, Vol.24 (1), p.110-114
Hauptverfasser:	Pardanani, A, Lasho, T L, Finke, C M, Gangat, N, Wolanskyj, A P, Hanson, C A, Tefferi, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Blood & organ donations Bone marrow Cancer Cancer Research Critical Care Medicine Diseases of red blood cells Female Gene mutations Genetic aspects Genetic Predisposition to Disease Genotype & phenotype Haplotypes Health aspects Hematologic and hematopoietic diseases Hematology Hemoglobin Humans Intensive Internal Medicine Janus Kinase 2 - genetics Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical prognosis Medical sciences Medicine Medicine & Public Health Middle Aged Mutation Oncology original-article Pathogenesis Polycythemias Polymorphism, Single Nucleotide Risk factors Thrombocythemia Thrombocythemia, Essential - genetics Thrombocytosis Thrombosis Tumors
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