Role of Endogenous ET-1 in the Regulation of Myocardial Blood Flow in Lean and Obese Humans

Endothelin is an important determinant of peripheral vascular tone, and increased endogenous endothelin activity contributes to peripheral vascular dysfunction in human obesity. The contributions of endothelin to the regulation of coronary vascular tone in health in humans have not been well studied...

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Veröffentlicht in:	Obesity (Silver Spring, Md.) Md.), 2010-01, Vol.18 (1), p.63-70
Hauptverfasser:	Mather, Kieren J, Lteif, Amale A, Veeneman, Emily, Fain, Richard, Giger, Susan, Perry, Kevin, Hutchins, Gary D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adult ammonia Analysis of Variance antagonists blood flow Blood Glucose - metabolism Blood pressure Body Mass Index Cardiovascular disease cholesterol Coronary Circulation - drug effects Coronary Circulation - physiology Diabetes diabetes mellitus Endothelin A Receptor Antagonists Endothelin-1 - physiology Endothelium Female Hemodynamics - drug effects Humans hyperlipidemia Hypertension Male Metabolism myocardium Nitric oxide Obesity Obesity - physiopathology Patient Selection Peptides, Cyclic - pharmacology Physiology Positron-Emission Tomography receptors Regression Analysis Tomography
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