β-Adrenergic-AMPK Pathway Phosphorylates Acetyl-CoA Carboxylase in a High-epinephrine Rat Model, SPORTS

We established a new animal model called SPORTS (Spontaneously-Running Tokushima-Shikoku) rats, which show high-epinephrine (Epi) levels. Recent reports show that Epi activates adenosine monophosphate (AMP)–activated protein kinase (AMPK) in adipocytes. Acetyl-CoA carboxylase (ACC) is the rate-limit...

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Veröffentlicht in:	Obesity (Silver Spring, Md.) Md.), 2010-01, Vol.18 (1), p.48-54
Hauptverfasser:	Hattori, Atsushi, Mawatari, Kazuaki, Tsuzuki, Satomi, Yoshioka, Emiko, Toda, Satomi, Yoshida, Masaki, Yasui, Sonoko, Furukawa, Hiroko, Morishima, Masaki, Ono, Katasushige, Ohnishi, Takamasa, Nakano,Masayuki, Harada, Nagakatsu, Takahashi, Akira, Nayaya, Yutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	abdominal fat acetyl-CoA carboxylase Acetyl-CoA Carboxylase - metabolism adenosine monophosphate adipocytes Adrenergic beta-Antagonists - pharmacology AMP-Activated Protein Kinases - metabolism Analysis of Variance animal models Animals antagonists Blood Glucose - metabolism Blotting, Western Body Weight - drug effects Body Weight - physiology Eating enzyme activity Enzyme-Linked Immunosorbent Assay Epinephrine - metabolism fatty acids food intake Glucose Tolerance Test glucose tolerance tests high fat diet Insulin - blood insulin resistance Intra-Abdominal Fat - drug effects Intra-Abdominal Fat - metabolism Male males obesity Obesity - metabolism phosphorylation Phosphorylation - drug effects propranolol Propranolol - pharmacology Pyrazoles - pharmacology Pyrimidines - pharmacology Rats Receptors, Adrenergic, beta - metabolism signal transduction sports sucrose triacylglycerols Up-Regulation - drug effects visceral fat weight gain Western blotting
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