Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP) by flavonoids and drug response

The present article aims to review the up-to-date information on the most recent studies of the interaction of flavonoids with ABC transporters, in particular the drug pharmacokinetic consequences of such a relationship. In addition, the modulation of the expression of the ABC transporters by flavon...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2010-02, Vol.99 (2), p.598-617
Hauptverfasser:	Alvarez, Ana I., Real, Rebeca, Pérez, Miriam, Mendoza, Gracia, Prieto, Julio G., Merino, Gracia
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporters Animals ATP Binding Cassette Transporter, Sub-Family G, Member 2 ATP-Binding Cassette Transporters - biosynthesis ATP-Binding Cassette Transporters - drug effects ATP-Binding Cassette Transporters - metabolism ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis ATP-Binding Cassette, Sub-Family B, Member 1 - drug effects ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism BCRP/ABCG2 Biological and medical sciences Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - metabolism drug interaction Enzyme Inhibitors - pharmacology flavonoids Flavonoids - metabolism Flavonoids - pharmacology Flavonoids - toxicity General pharmacology Humans Medical sciences MRP2/ABCC2 Multidrug Resistance-Associated Proteins - biosynthesis Multidrug Resistance-Associated Proteins - drug effects Multidrug Resistance-Associated Proteins - metabolism Neoplasm Proteins - biosynthesis Neoplasm Proteins - drug effects Neoplasm Proteins - metabolism P-glycoprotein/ABCB1 Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments
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