Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP) by flavonoids and drug response
The present article aims to review the up-to-date information on the most recent studies of the interaction of flavonoids with ABC transporters, in particular the drug pharmacokinetic consequences of such a relationship. In addition, the modulation of the expression of the ABC transporters by flavon...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 2010-02, Vol.99 (2), p.598-617 |
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| creator | Alvarez, Ana I. Real, Rebeca Pérez, Miriam Mendoza, Gracia Prieto, Julio G. Merino, Gracia |
| description | The present article aims to review the up-to-date information on the most recent studies of the interaction of flavonoids with ABC transporters, in particular the drug pharmacokinetic consequences of such a relationship. In addition, the modulation of the expression of the ABC transporters by flavonoids is also illustrated. Flavonoids are a large group of plant polyphenols present extensively in our daily diets and herbal products. High intake of isoflavones has been associated with a variety of beneficial effects on several common diseases. These polyphenols interact with ABC drug transporters involved in drug resistance and drug absorption, distribution and excretion. A number of studies have demonstrated inhibition of drug transporters by flavonoids. This flavonoid-ABC-transporter interaction could be beneficial for poorly absorbed drugs but could also result in severe drug intoxication, especially drugs with a narrow therapeutic window. On the other hand, flavonoids are themselves substrates of ABC transporters. These proteins can affect the oral availability and tissue distribution of these compounds, modifying their beneficial effects. The challenge is to find a suitable way to predict harmful drug–flavonoid interactions mediated by these transporters. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:598–617, 2010 |
| doi_str_mv | 10.1002/jps.21851 |
| format | Article |
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In addition, the modulation of the expression of the ABC transporters by flavonoids is also illustrated. Flavonoids are a large group of plant polyphenols present extensively in our daily diets and herbal products. High intake of isoflavones has been associated with a variety of beneficial effects on several common diseases. These polyphenols interact with ABC drug transporters involved in drug resistance and drug absorption, distribution and excretion. A number of studies have demonstrated inhibition of drug transporters by flavonoids. This flavonoid-ABC-transporter interaction could be beneficial for poorly absorbed drugs but could also result in severe drug intoxication, especially drugs with a narrow therapeutic window. On the other hand, flavonoids are themselves substrates of ABC transporters. These proteins can affect the oral availability and tissue distribution of these compounds, modifying their beneficial effects. The challenge is to find a suitable way to predict harmful drug–flavonoid interactions mediated by these transporters. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:598–617, 2010</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.21851</identifier><identifier>PMID: 19544374</identifier><identifier>CODEN: JPMSAE</identifier><language>eng</language><publisher>Hoboken: Elsevier Inc</publisher><subject>ABC transporters ; Animals ; ATP Binding Cassette Transporter, Sub-Family G, Member 2 ; ATP-Binding Cassette Transporters - biosynthesis ; ATP-Binding Cassette Transporters - drug effects ; ATP-Binding Cassette Transporters - metabolism ; ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis ; ATP-Binding Cassette, Sub-Family B, Member 1 - drug effects ; ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism ; BCRP/ABCG2 ; Biological and medical sciences ; Cytochrome P-450 Enzyme Inhibitors ; Cytochrome P-450 Enzyme System - metabolism ; drug interaction ; Enzyme Inhibitors - pharmacology ; flavonoids ; Flavonoids - metabolism ; Flavonoids - pharmacology ; Flavonoids - toxicity ; General pharmacology ; Humans ; Medical sciences ; MRP2/ABCC2 ; Multidrug Resistance-Associated Proteins - biosynthesis ; Multidrug Resistance-Associated Proteins - drug effects ; Multidrug Resistance-Associated Proteins - metabolism ; Neoplasm Proteins - biosynthesis ; Neoplasm Proteins - drug effects ; Neoplasm Proteins - metabolism ; P-glycoprotein/ABCB1 ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments</subject><ispartof>Journal of pharmaceutical sciences, 2010-02, Vol.99 (2), p.598-617</ispartof><rights>2010 Wiley-Liss, Inc.</rights><rights>Copyright © 2009 Wiley‐Liss, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>(c) 2009 Wiley-Liss, Inc. and the American Pharmacists Association.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5021-361adc1cc64e2e8bd4ba68b8741b56b0afd52e8a5217cf24c48206b4c9c092043</citedby><cites>FETCH-LOGICAL-c5021-361adc1cc64e2e8bd4ba68b8741b56b0afd52e8a5217cf24c48206b4c9c092043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.21851$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.21851$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22364417$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19544374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alvarez, Ana I.</creatorcontrib><creatorcontrib>Real, Rebeca</creatorcontrib><creatorcontrib>Pérez, Miriam</creatorcontrib><creatorcontrib>Mendoza, Gracia</creatorcontrib><creatorcontrib>Prieto, Julio G.</creatorcontrib><creatorcontrib>Merino, Gracia</creatorcontrib><title>Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP) by flavonoids and drug response</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>The present article aims to review the up-to-date information on the most recent studies of the interaction of flavonoids with ABC transporters, in particular the drug pharmacokinetic consequences of such a relationship. In addition, the modulation of the expression of the ABC transporters by flavonoids is also illustrated. Flavonoids are a large group of plant polyphenols present extensively in our daily diets and herbal products. High intake of isoflavones has been associated with a variety of beneficial effects on several common diseases. These polyphenols interact with ABC drug transporters involved in drug resistance and drug absorption, distribution and excretion. A number of studies have demonstrated inhibition of drug transporters by flavonoids. This flavonoid-ABC-transporter interaction could be beneficial for poorly absorbed drugs but could also result in severe drug intoxication, especially drugs with a narrow therapeutic window. On the other hand, flavonoids are themselves substrates of ABC transporters. These proteins can affect the oral availability and tissue distribution of these compounds, modifying their beneficial effects. The challenge is to find a suitable way to predict harmful drug–flavonoid interactions mediated by these transporters. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:598–617, 2010</description><subject>ABC transporters</subject><subject>Animals</subject><subject>ATP Binding Cassette Transporter, Sub-Family G, Member 2</subject><subject>ATP-Binding Cassette Transporters - biosynthesis</subject><subject>ATP-Binding Cassette Transporters - drug effects</subject><subject>ATP-Binding Cassette Transporters - metabolism</subject><subject>ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis</subject><subject>ATP-Binding Cassette, Sub-Family B, Member 1 - drug effects</subject><subject>ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism</subject><subject>BCRP/ABCG2</subject><subject>Biological and medical sciences</subject><subject>Cytochrome P-450 Enzyme Inhibitors</subject><subject>Cytochrome P-450 Enzyme System - metabolism</subject><subject>drug interaction</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>flavonoids</subject><subject>Flavonoids - metabolism</subject><subject>Flavonoids - pharmacology</subject><subject>Flavonoids - toxicity</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>MRP2/ABCC2</subject><subject>Multidrug Resistance-Associated Proteins - biosynthesis</subject><subject>Multidrug Resistance-Associated Proteins - drug effects</subject><subject>Multidrug Resistance-Associated Proteins - metabolism</subject><subject>Neoplasm Proteins - biosynthesis</subject><subject>Neoplasm Proteins - drug effects</subject><subject>Neoplasm Proteins - metabolism</subject><subject>P-glycoprotein/ABCB1</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFu1DAQhi0EokvhwAsgX1Cp1LS2YyfZY3cFLVVblgJC6sVy7Elxm40X21mat8dLlnKhJ8ueb-Yffwi9puSQEsKOblfhkNFK0CdoQgUjWUFo-RRNUo1lueDTHfQihFtCSEGEeI526FRwnpd8gu4unOlbFa3rsGtw_AFY6WjXNg6b-_FsjqNXXVg5H8EH_G6R3bSDdivvItjuAF9cLdgBns2vFvu4HnDTqrXrnDUBq85g4_sb7CG1dwFeomeNagO82p676NuH91_np9n5p5OP8-PzTAvCaJYXVBlNtS44MKhqw2tVVHVVclqLoiaqMSK9K8FoqRvGNa8YKWqup5pMGeH5Ltob56Ylf_YQolzaoKFtVQeuD7LMUwRJYCL3R1J7F4KHRq68XSo_SErkRq1MauUftYl9s53a10sw_8itywS83QIqaNU2SZu24YFjLC84p2Xijkbul21heDxRni2-_I3Oxg4bItw_dCh_J4syL4X8fnkiz66vyYzRz3KzST7ykCyvLXgZtIVOg7EedJTG2f988Dd8S69m</recordid><startdate>201002</startdate><enddate>201002</enddate><creator>Alvarez, Ana I.</creator><creator>Real, Rebeca</creator><creator>Pérez, Miriam</creator><creator>Mendoza, Gracia</creator><creator>Prieto, Julio G.</creator><creator>Merino, Gracia</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>American Pharmaceutical Association</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201002</creationdate><title>Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP) by flavonoids and drug response</title><author>Alvarez, Ana I. ; Real, Rebeca ; Pérez, Miriam ; Mendoza, Gracia ; Prieto, Julio G. ; Merino, Gracia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5021-361adc1cc64e2e8bd4ba68b8741b56b0afd52e8a5217cf24c48206b4c9c092043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>ABC transporters</topic><topic>Animals</topic><topic>ATP Binding Cassette Transporter, Sub-Family G, Member 2</topic><topic>ATP-Binding Cassette Transporters - biosynthesis</topic><topic>ATP-Binding Cassette Transporters - drug effects</topic><topic>ATP-Binding Cassette Transporters - metabolism</topic><topic>ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis</topic><topic>ATP-Binding Cassette, Sub-Family B, Member 1 - drug effects</topic><topic>ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism</topic><topic>BCRP/ABCG2</topic><topic>Biological and medical sciences</topic><topic>Cytochrome P-450 Enzyme Inhibitors</topic><topic>Cytochrome P-450 Enzyme System - metabolism</topic><topic>drug interaction</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>flavonoids</topic><topic>Flavonoids - metabolism</topic><topic>Flavonoids - pharmacology</topic><topic>Flavonoids - toxicity</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>MRP2/ABCC2</topic><topic>Multidrug Resistance-Associated Proteins - biosynthesis</topic><topic>Multidrug Resistance-Associated Proteins - drug effects</topic><topic>Multidrug Resistance-Associated Proteins - metabolism</topic><topic>Neoplasm Proteins - biosynthesis</topic><topic>Neoplasm Proteins - drug effects</topic><topic>Neoplasm Proteins - metabolism</topic><topic>P-glycoprotein/ABCB1</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alvarez, Ana I.</creatorcontrib><creatorcontrib>Real, Rebeca</creatorcontrib><creatorcontrib>Pérez, Miriam</creatorcontrib><creatorcontrib>Mendoza, Gracia</creatorcontrib><creatorcontrib>Prieto, Julio G.</creatorcontrib><creatorcontrib>Merino, Gracia</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alvarez, Ana I.</au><au>Real, Rebeca</au><au>Pérez, Miriam</au><au>Mendoza, Gracia</au><au>Prieto, Julio G.</au><au>Merino, Gracia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP) by flavonoids and drug response</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>2010-02</date><risdate>2010</risdate><volume>99</volume><issue>2</issue><spage>598</spage><epage>617</epage><pages>598-617</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><coden>JPMSAE</coden><abstract>The present article aims to review the up-to-date information on the most recent studies of the interaction of flavonoids with ABC transporters, in particular the drug pharmacokinetic consequences of such a relationship. In addition, the modulation of the expression of the ABC transporters by flavonoids is also illustrated. Flavonoids are a large group of plant polyphenols present extensively in our daily diets and herbal products. High intake of isoflavones has been associated with a variety of beneficial effects on several common diseases. These polyphenols interact with ABC drug transporters involved in drug resistance and drug absorption, distribution and excretion. A number of studies have demonstrated inhibition of drug transporters by flavonoids. This flavonoid-ABC-transporter interaction could be beneficial for poorly absorbed drugs but could also result in severe drug intoxication, especially drugs with a narrow therapeutic window. On the other hand, flavonoids are themselves substrates of ABC transporters. These proteins can affect the oral availability and tissue distribution of these compounds, modifying their beneficial effects. The challenge is to find a suitable way to predict harmful drug–flavonoid interactions mediated by these transporters. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:598–617, 2010</abstract><cop>Hoboken</cop><pub>Elsevier Inc</pub><pmid>19544374</pmid><doi>10.1002/jps.21851</doi><tpages>20</tpages></addata></record> |
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| subjects | ABC transporters Animals ATP Binding Cassette Transporter, Sub-Family G, Member 2 ATP-Binding Cassette Transporters - biosynthesis ATP-Binding Cassette Transporters - drug effects ATP-Binding Cassette Transporters - metabolism ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis ATP-Binding Cassette, Sub-Family B, Member 1 - drug effects ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism BCRP/ABCG2 Biological and medical sciences Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - metabolism drug interaction Enzyme Inhibitors - pharmacology flavonoids Flavonoids - metabolism Flavonoids - pharmacology Flavonoids - toxicity General pharmacology Humans Medical sciences MRP2/ABCC2 Multidrug Resistance-Associated Proteins - biosynthesis Multidrug Resistance-Associated Proteins - drug effects Multidrug Resistance-Associated Proteins - metabolism Neoplasm Proteins - biosynthesis Neoplasm Proteins - drug effects Neoplasm Proteins - metabolism P-glycoprotein/ABCB1 Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments |
| title | Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP) by flavonoids and drug response |
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