Vascular targeting by EndoTAG™‐1 enhances therapeutic efficacy of conventional chemotherapy in lung and pancreatic cancer

Cationic lipid complexed paclitaxel (EndoTAG™‐1) is a novel vascular targeting agent for the treatment of cancer. Here, the aim was to investigate intratumoral drug distribution after EndoTAG™‐1 therapy and analyze the impact of EndoTAG™‐1 scheduling on antitumoral efficacy. The therapeutic effect o...

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Veröffentlicht in:	International journal of cancer 2010-03, Vol.126 (5), p.1235-1245
Hauptverfasser:	Eichhorn, Martin E., Ischenko, Ivan, Luedemann, Siiri, Strieth, Sebastian, Papyan, Armine, Werner, Alexander, Bohnenkamp, Hermann, Guenzi, Eric, Preissler, Gerhard, Michaelis, Uwe, Jauch, Karl‐Walter, Bruns, Christiane J., Dellian, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Biological and medical sciences Carcinoma, Lewis Lung cationic liposomes Cisplatin - administration & dosage combination therapy Cricetinae Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Drug Administration Schedule Drug Delivery Systems Humans Immunohistochemistry Lipopeptides Liposomes Lung Neoplasms - blood supply Lung Neoplasms - drug therapy Male Medical sciences Mice Neovascularization, Pathologic - drug therapy paclitaxel Paclitaxel - administration & dosage Pancreatic Neoplasms - blood supply Pancreatic Neoplasms - drug therapy Pneumology tumor angiogenesis Tumors Tumors of the respiratory system and mediastinum vascular targeting therapy
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