Regulatory role of DC‐derived osteopontin in systemic allergen sensitization

Osteopontin (OPN) is a secreted phosphoglycoprotein with a wide range of functions, and is involved in various pathophysiological conditions. However, the role of OPN in IgE and Th2‐associated allergic responses remains incompletely defined. The aim of this study was to elucidate the role of OPN in...

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Veröffentlicht in:	European journal of immunology 2009-12, Vol.39 (12), p.3323-3330
Hauptverfasser:	Kurokawa, Masatsugu, Konno, Satoshi, Takahashi, Ayumu, Plunkett, Beverly, Rittling, Susan R., Matsui, Yutaka, Kon, Shigeyuki, Morimoto, Junko, Uede, Toshimitsu, Matsukura, Satoshi, Kokubu, Fumio, Adachi, Mitsuru, Nishimura, Masaharu, Huang, Shau‐Ku
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Allergens - immunology Animals Bone marrow‐derived DC Bronchial Hyperreactivity - genetics Bronchial Hyperreactivity - immunology Bronchial Hyperreactivity - metabolism CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - metabolism Enzyme-Linked Immunosorbent Assay IgE Immunoglobulin E - blood Immunoglobulin E - immunology Immunoglobulin G - blood Immunoglobulin G - immunology Interferon-gamma - metabolism Interleukin-12 - genetics Interleukin-12 - metabolism Interleukin-13 - metabolism Lipopolysaccharides - pharmacology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Osteopontin Osteopontin - genetics Osteopontin - metabolism Ovalbumin - immunology Recombinant Proteins - pharmacology Th2 cytokines
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