Th17 cytokine IL-22 induces IL-20 production in keratinocytes: A novel immunological cascade with potential relevance in psoriasis

Psoriasis is a common chronic skin disease. Recent studies demonstrated that IL-20 and IL-22, cytokines produced by keratinocytes and T cells, respectively, both inhibit keratinocyte terminal differentiation and induce psoriasis-like epidermis alterations. Here, we investigated the relationship betw...

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Veröffentlicht in:	European journal of immunology 2009-12, Vol.39 (12), p.3570-3581
Hauptverfasser:	Wolk, Kerstin, Witte, Ellen, Warszawska, Katarzyna, Schulze-Tanzil, Gundula, Witte, Katrin, Philipp, Sandra, Kunz, Stefanie, Döcke, Wolf-Dietrich, Asadullah, Khusru, Volk, Hans-Dieter, Sterry, Wolfram, Sabat, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmune disease Cells, Cultured Cytokines Enzyme-Linked Immunosorbent Assay Humans IL‐10 cytokine family Immunohistochemistry Inflammation Interleukin-17 - metabolism Interleukin-22 Interleukins - genetics Interleukins - metabolism Interleukins - pharmacology Keratinocytes - cytology Keratinocytes - drug effects Keratinocytes - metabolism Male Mice Mice, Inbred BALB C Psoriasis - blood Psoriasis - immunology Psoriasis - pathology Reverse Transcriptase Polymerase Chain Reaction RNA Stability - drug effects RNA, Messenger - genetics RNA, Messenger - metabolism Severity of Illness Index Skin Skin - immunology Skin - metabolism Skin - pathology T-Lymphocytes, Helper-Inducer - metabolism Tumor Necrosis Factor-alpha - metabolism
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