The initial phase of fracture healing is specifically sensitive to mechanical conditions
Interfragmentary movements affect the quality and quantity of callus formation. The mounting plane of monolateral external fixators may give direction to those movements. Therefore, the aim of this study was to determine the influence of the fixator mounting plane on the process of fracture healing....
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| Veröffentlicht in: | Journal of orthopaedic research 2003-07, Vol.21 (4), p.662-669 |
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| container_title | Journal of orthopaedic research |
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| creator | Klein, Petra Schell, Hanna Streitparth, Florian Heller, Markus Kassi, Jean-Pierre Kandziora, Frank Bragulla, Hermann Haas, Norbert P Duda, Georg N |
| description | Interfragmentary movements affect the quality and quantity of callus formation. The mounting plane of monolateral external fixators may give direction to those movements. Therefore, the aim of this study was to determine the influence of the fixator mounting plane on the process of fracture healing.
Identically configured fixators were mounted either medially or anteromedially on the tibiae of sheep. Interfragmentary movements and ground reaction forces were evaluated in vivo during a nine week period. Histomorphological and biomechanical parameters described the bone healing processes.
Changing only the mounting plane led to a modification of interfragmentary movements in the initial healing phase. The difference in interfragmentary movements between the groups was only significant during the first post-operative period. However, these initial differences in mechanical conditions influenced callus tissue formation significantly. The group with the anteromedially mounted fixator, initially showing significantly more interfragmentary movements, ended up with a significantly smaller callus diameter and a significantly higher callus stiffness as a result of advanced fracture healing. This demonstrates that the initial phase of healing is sensitive to mechanical conditions and influences the course of healing. Therefore, initial mechanical stability of an osteosynthesis should be considered an important factor in clinical fracture treatment. |
| doi_str_mv | 10.1016/S0736-0266(02)00259-0 |
| format | Article |
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Identically configured fixators were mounted either medially or anteromedially on the tibiae of sheep. Interfragmentary movements and ground reaction forces were evaluated in vivo during a nine week period. Histomorphological and biomechanical parameters described the bone healing processes.
Changing only the mounting plane led to a modification of interfragmentary movements in the initial healing phase. The difference in interfragmentary movements between the groups was only significant during the first post-operative period. However, these initial differences in mechanical conditions influenced callus tissue formation significantly. The group with the anteromedially mounted fixator, initially showing significantly more interfragmentary movements, ended up with a significantly smaller callus diameter and a significantly higher callus stiffness as a result of advanced fracture healing. This demonstrates that the initial phase of healing is sensitive to mechanical conditions and influences the course of healing. Therefore, initial mechanical stability of an osteosynthesis should be considered an important factor in clinical fracture treatment.</description><identifier>ISSN: 0736-0266</identifier><identifier>EISSN: 1554-527X</identifier><identifier>DOI: 10.1016/S0736-0266(02)00259-0</identifier><identifier>PMID: 12798066</identifier><identifier>CODEN: JOREDR</identifier><language>eng</language><publisher>Hoboken: Elsevier Ltd</publisher><subject>Animals ; Bony Callus - physiology ; External fixator ; External Fixators ; Female ; Fracture healing ; Fracture Healing - physiology ; Interfragmentary movements ; Sheep ; Stress, Mechanical ; Tibial Fractures - physiopathology ; Tibial Fractures - surgery ; Torque ; Torsion Abnormality ; Weight-Bearing</subject><ispartof>Journal of orthopaedic research, 2003-07, Vol.21 (4), p.662-669</ispartof><rights>2003 Orthopaedic Research Society</rights><rights>Copyright © 2003 Orthopaedic Research Society</rights><rights>Copyright Journal of Bone and Joint Surgery, Inc. Jul 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5664-9c4fdf3ee0e0cc39ead828093697e88f41a84f04f475ecfa1c652c63fc8165b43</citedby><cites>FETCH-LOGICAL-c5664-9c4fdf3ee0e0cc39ead828093697e88f41a84f04f475ecfa1c652c63fc8165b43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2FS0736-0266%2802%2900259-0$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2FS0736-0266%2802%2900259-0$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27904,27905,45554,45555,46389,46813</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12798066$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klein, Petra</creatorcontrib><creatorcontrib>Schell, Hanna</creatorcontrib><creatorcontrib>Streitparth, Florian</creatorcontrib><creatorcontrib>Heller, Markus</creatorcontrib><creatorcontrib>Kassi, Jean-Pierre</creatorcontrib><creatorcontrib>Kandziora, Frank</creatorcontrib><creatorcontrib>Bragulla, Hermann</creatorcontrib><creatorcontrib>Haas, Norbert P</creatorcontrib><creatorcontrib>Duda, Georg N</creatorcontrib><title>The initial phase of fracture healing is specifically sensitive to mechanical conditions</title><title>Journal of orthopaedic research</title><addtitle>J. Orthop. Res</addtitle><description>Interfragmentary movements affect the quality and quantity of callus formation. The mounting plane of monolateral external fixators may give direction to those movements. Therefore, the aim of this study was to determine the influence of the fixator mounting plane on the process of fracture healing.
Identically configured fixators were mounted either medially or anteromedially on the tibiae of sheep. Interfragmentary movements and ground reaction forces were evaluated in vivo during a nine week period. Histomorphological and biomechanical parameters described the bone healing processes.
Changing only the mounting plane led to a modification of interfragmentary movements in the initial healing phase. The difference in interfragmentary movements between the groups was only significant during the first post-operative period. However, these initial differences in mechanical conditions influenced callus tissue formation significantly. The group with the anteromedially mounted fixator, initially showing significantly more interfragmentary movements, ended up with a significantly smaller callus diameter and a significantly higher callus stiffness as a result of advanced fracture healing. This demonstrates that the initial phase of healing is sensitive to mechanical conditions and influences the course of healing. Therefore, initial mechanical stability of an osteosynthesis should be considered an important factor in clinical fracture treatment.</description><subject>Animals</subject><subject>Bony Callus - physiology</subject><subject>External fixator</subject><subject>External Fixators</subject><subject>Female</subject><subject>Fracture healing</subject><subject>Fracture Healing - physiology</subject><subject>Interfragmentary movements</subject><subject>Sheep</subject><subject>Stress, Mechanical</subject><subject>Tibial Fractures - physiopathology</subject><subject>Tibial Fractures - surgery</subject><subject>Torque</subject><subject>Torsion Abnormality</subject><subject>Weight-Bearing</subject><issn>0736-0266</issn><issn>1554-527X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkc1uEzEURi0EoqHwCCCLBYLFgP_tWQFKaAFFVEARFRvL9VwTl8lMsGcKeXs8TVQkNmVjy_a5n3zvQeghJc8poerFZ6K5qghT6ilhzwhhsq7ILTSjUopKMn12G82ukQN0L-cLQoimzNxFB5Tp2hClZujsdAU4dnGIrsWblcuA-4BDcn4YE-AVuDZ233HMOG_AxxC9a9stztDlUnMJeOjxGvzKddML9n3XlPu-y_fRneDaDA_2-yH6cvTmdP62Wp4cv5u_XlZeKiWq2ovQBA5AgHjPa3CNYYbUXNUajAmCOiMCEUFoCT446pVkXvHgDVXyXPBD9GSXu0n9zxHyYNcxe2hb10E_Zqs5V0TX5EaQmpoxJk0BH_8DXvRj6koTlnFJKWNCFkjuIJ_6nBMEu0lx7dLWUmInQfZKkJ2mXxZ7JchOv3i0Dx_P19D8rdobKcCrHfArtrD9v1T7_uQTpeVAiaDTSKpdRMwD_L6OcOmHVZprab9-OLaLj98WYnk0t4vCv9zxUDxdRkg2-widhyYm8INt-nhDV38AOF7BFw</recordid><startdate>200307</startdate><enddate>200307</enddate><creator>Klein, Petra</creator><creator>Schell, Hanna</creator><creator>Streitparth, Florian</creator><creator>Heller, Markus</creator><creator>Kassi, Jean-Pierre</creator><creator>Kandziora, Frank</creator><creator>Bragulla, Hermann</creator><creator>Haas, Norbert P</creator><creator>Duda, Georg N</creator><general>Elsevier Ltd</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>200307</creationdate><title>The initial phase of fracture healing is specifically sensitive to mechanical conditions</title><author>Klein, Petra ; Schell, Hanna ; Streitparth, Florian ; Heller, Markus ; Kassi, Jean-Pierre ; Kandziora, Frank ; Bragulla, Hermann ; Haas, Norbert P ; Duda, Georg N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5664-9c4fdf3ee0e0cc39ead828093697e88f41a84f04f475ecfa1c652c63fc8165b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Bony Callus - physiology</topic><topic>External fixator</topic><topic>External Fixators</topic><topic>Female</topic><topic>Fracture healing</topic><topic>Fracture Healing - physiology</topic><topic>Interfragmentary movements</topic><topic>Sheep</topic><topic>Stress, Mechanical</topic><topic>Tibial Fractures - physiopathology</topic><topic>Tibial Fractures - surgery</topic><topic>Torque</topic><topic>Torsion Abnormality</topic><topic>Weight-Bearing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klein, Petra</creatorcontrib><creatorcontrib>Schell, Hanna</creatorcontrib><creatorcontrib>Streitparth, Florian</creatorcontrib><creatorcontrib>Heller, Markus</creatorcontrib><creatorcontrib>Kassi, Jean-Pierre</creatorcontrib><creatorcontrib>Kandziora, Frank</creatorcontrib><creatorcontrib>Bragulla, Hermann</creatorcontrib><creatorcontrib>Haas, Norbert P</creatorcontrib><creatorcontrib>Duda, Georg N</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of orthopaedic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klein, Petra</au><au>Schell, Hanna</au><au>Streitparth, Florian</au><au>Heller, Markus</au><au>Kassi, Jean-Pierre</au><au>Kandziora, Frank</au><au>Bragulla, Hermann</au><au>Haas, Norbert P</au><au>Duda, Georg N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The initial phase of fracture healing is specifically sensitive to mechanical conditions</atitle><jtitle>Journal of orthopaedic research</jtitle><addtitle>J. Orthop. Res</addtitle><date>2003-07</date><risdate>2003</risdate><volume>21</volume><issue>4</issue><spage>662</spage><epage>669</epage><pages>662-669</pages><issn>0736-0266</issn><eissn>1554-527X</eissn><coden>JOREDR</coden><abstract>Interfragmentary movements affect the quality and quantity of callus formation. The mounting plane of monolateral external fixators may give direction to those movements. Therefore, the aim of this study was to determine the influence of the fixator mounting plane on the process of fracture healing.
Identically configured fixators were mounted either medially or anteromedially on the tibiae of sheep. Interfragmentary movements and ground reaction forces were evaluated in vivo during a nine week period. Histomorphological and biomechanical parameters described the bone healing processes.
Changing only the mounting plane led to a modification of interfragmentary movements in the initial healing phase. The difference in interfragmentary movements between the groups was only significant during the first post-operative period. However, these initial differences in mechanical conditions influenced callus tissue formation significantly. The group with the anteromedially mounted fixator, initially showing significantly more interfragmentary movements, ended up with a significantly smaller callus diameter and a significantly higher callus stiffness as a result of advanced fracture healing. This demonstrates that the initial phase of healing is sensitive to mechanical conditions and influences the course of healing. Therefore, initial mechanical stability of an osteosynthesis should be considered an important factor in clinical fracture treatment.</abstract><cop>Hoboken</cop><pub>Elsevier Ltd</pub><pmid>12798066</pmid><doi>10.1016/S0736-0266(02)00259-0</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of orthopaedic research, 2003-07, Vol.21 (4), p.662-669 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Free Content; Alma/SFX Local Collection |
| subjects | Animals Bony Callus - physiology External fixator External Fixators Female Fracture healing Fracture Healing - physiology Interfragmentary movements Sheep Stress, Mechanical Tibial Fractures - physiopathology Tibial Fractures - surgery Torque Torsion Abnormality Weight-Bearing |
| title | The initial phase of fracture healing is specifically sensitive to mechanical conditions |
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