The Anti-angiogenic Activity of NSITC, a Specific Cathepsin L Inhibitor

Increased neovasculature and resistance to chemotherapy are hallmarks of aggressive cancer; therefore, the development of approaches to simultaneously inhibit these two processes is highly desirable. Previous findings from our laboratory have demonstrated that cathepsin L plays a key role in the dev...

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Veröffentlicht in:	Anticancer research 2009-11, Vol.29 (11), p.4473-4481
Hauptverfasser:	Rebbaa, Abdelhadi, Chu, Fei, Sudha, Thangirala, Gallati, Christine, Dier, Usawadee, Dyskin, Evgeny, Yalcin, Murat, Bianchini, Christine, Shaker, Olfat, Mousa, Shaker A
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - pharmacology Animals Cathepsin L - antagonists & inhibitors Cell Adhesion - drug effects Cell Movement - drug effects Chick Embryo Dipeptides - pharmacology Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - enzymology Humans Male Mice Mice, Inbred C57BL Neovascularization, Physiologic - drug effects Protease Inhibitors - pharmacology
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