Ror‐family receptor tyrosine kinases in noncanonical Wnt signaling: Their implications in developmental morphogenesis and human diseases

The Ror‐family receptor tyrosine kinases (RTKs) play crucial roles in the development of various organs and tissues. In mammals, Ror2, a member of the Ror‐family RTKs, has been shown to act as a receptor or coreceptor for Wnt5a to mediate noncanonical Wnt signaling. Ror2‐ and Wnt5a‐deficient mice ex...

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Veröffentlicht in:	Developmental dynamics 2010-01, Vol.239 (1), p.1-15
Hauptverfasser:	Minami, Yasuhiro, Oishi, Isao, Endo, Mitsuharu, Nishita, Michiru
Format:	Artikel
Sprache:	eng
Schlagworte:	brachydactyly type B (BDB) Cell Movement - physiology Cell Polarity - physiology convergent extension (CE) movements cytoskeletal reorganization developmental expression Gene Expression Regulation, Developmental - physiology Genetic Diseases, Inborn - genetics Humans Models, Biological Morphogenesis - physiology noncanonical Wnt signaling planar cell polarity (PCP) polarized cell migration Proto-Oncogene Proteins - metabolism Receptor Tyrosine Kinase-like Orphan Receptors - metabolism recessive Robinow syndrome (RRS) Ror1 Ror2 Ror‐family receptor tyrosine kinases (RTKs) Signal Transduction - physiology tumor invasion Wnt Proteins - metabolism Wnt-5a Protein Wnt/JNK pathway Wnt/β‐catenin pathway Wnt5a
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