Vascular disease burden and in-hospital outcomes among patients undergoing percutaneous coronary intervention in New York State
The presence of atherosclerosis in extracardiac vascular beds is associated with an increased risk of adverse cardiovascular outcomes among stable patients with coronary artery disease (CAD). However, there is little data regarding the impact of the presence and extent of vascular disease on outcome...
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| Veröffentlicht in: | Circulation. Cardiovascular interventions 2009-08, Vol.2 (4), p.317-322 |
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| creator | Berger, Jeffrey S Petersen, John L Brown, David L |
| description | The presence of atherosclerosis in extracardiac vascular beds is associated with an increased risk of adverse cardiovascular outcomes among stable patients with coronary artery disease (CAD). However, there is little data regarding the impact of the presence and extent of vascular disease on outcomes in patients with CAD undergoing percutaneous coronary intervention.
We analyzed 69,045 consecutive patients from the New York State Coronary Angioplasty Reporting System database who underwent percutaneous coronary intervention between 1998 and 1999. Vascular disease burden was assessed by history of aortoiliac, femoral-popliteal, and carotid disease. Patients were stratified into 3 groups: CAD alone, CAD and 1 additional site, and CAD and 2 or 3 additional sites. A logistic regression model was constructed to determine the relation between vascular disease burden and in-hospital mortality. Any history of vascular disease was present in 5915 (8.6%) of the population, of whom 4840 (82%) had CAD and 1 other disease location and 1075 (18%) had CAD and 2 or 3 other disease locations. There was a significant relationship between the number of disease locations and hospital mortality, ranging from 0.7% in patients with CAD alone to 2.0% and 2.6% for patients with 1 or >or =2 disease locations, respectively (P |
| doi_str_mv | 10.1161/CIRCINTERVENTIONS.108.847459.108.847459 |
| format | Article |
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We analyzed 69,045 consecutive patients from the New York State Coronary Angioplasty Reporting System database who underwent percutaneous coronary intervention between 1998 and 1999. Vascular disease burden was assessed by history of aortoiliac, femoral-popliteal, and carotid disease. Patients were stratified into 3 groups: CAD alone, CAD and 1 additional site, and CAD and 2 or 3 additional sites. A logistic regression model was constructed to determine the relation between vascular disease burden and in-hospital mortality. Any history of vascular disease was present in 5915 (8.6%) of the population, of whom 4840 (82%) had CAD and 1 other disease location and 1075 (18%) had CAD and 2 or 3 other disease locations. There was a significant relationship between the number of disease locations and hospital mortality, ranging from 0.7% in patients with CAD alone to 2.0% and 2.6% for patients with 1 or >or =2 disease locations, respectively (P<0.001). In unadjusted analysis, in-hospital mortality was approximately 3-fold higher (odds ratio, 2.89; 95% CI, 2.31 to 3.60; P<0.001) and 4-fold higher (odds ratio, 3.78; 95% CI, 2.57 to 5.56; P<0.001) for inpatients with CAD and additional vascular disease at 1 site and > or =2 sites, respectively. After multivariable adjustment, each additional vascular bed affected was associated with a 50% increase in in-hospital mortality (odds ratio, 1.50; 95% CI, 1.27 to 1.78; P<0.001).
Among patients with CAD undergoing percutaneous coronary intervention, vascular disease burden is associated with higher rates of adverse events and is an independent predictor of in-hospital mortality.</description><identifier>ISSN: 1941-7640</identifier><identifier>EISSN: 1941-7632</identifier><identifier>DOI: 10.1161/CIRCINTERVENTIONS.108.847459.108.847459</identifier><identifier>PMID: 20031734</identifier><language>eng</language><publisher>United States</publisher><subject>Aged ; Angioplasty, Balloon, Coronary - adverse effects ; Angioplasty, Balloon, Coronary - mortality ; Atherosclerosis - complications ; Atherosclerosis - mortality ; Coronary Artery Disease - complications ; Coronary Artery Disease - mortality ; Coronary Artery Disease - therapy ; Female ; Heart Diseases - etiology ; Heart Diseases - mortality ; Hospital Mortality ; Humans ; Logistic Models ; Male ; Middle Aged ; New York ; Odds Ratio ; Peripheral Vascular Diseases - complications ; Peripheral Vascular Diseases - mortality ; Registries ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome</subject><ispartof>Circulation. Cardiovascular interventions, 2009-08, Vol.2 (4), p.317-322</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-9a70e68db201b9ffa52deae347635bdf154c2beeb7f2f7a69d06e909288729053</citedby><cites>FETCH-LOGICAL-c509t-9a70e68db201b9ffa52deae347635bdf154c2beeb7f2f7a69d06e909288729053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3686,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20031734$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berger, Jeffrey S</creatorcontrib><creatorcontrib>Petersen, John L</creatorcontrib><creatorcontrib>Brown, David L</creatorcontrib><title>Vascular disease burden and in-hospital outcomes among patients undergoing percutaneous coronary intervention in New York State</title><title>Circulation. Cardiovascular interventions</title><addtitle>Circ Cardiovasc Interv</addtitle><description>The presence of atherosclerosis in extracardiac vascular beds is associated with an increased risk of adverse cardiovascular outcomes among stable patients with coronary artery disease (CAD). However, there is little data regarding the impact of the presence and extent of vascular disease on outcomes in patients with CAD undergoing percutaneous coronary intervention.
We analyzed 69,045 consecutive patients from the New York State Coronary Angioplasty Reporting System database who underwent percutaneous coronary intervention between 1998 and 1999. Vascular disease burden was assessed by history of aortoiliac, femoral-popliteal, and carotid disease. Patients were stratified into 3 groups: CAD alone, CAD and 1 additional site, and CAD and 2 or 3 additional sites. A logistic regression model was constructed to determine the relation between vascular disease burden and in-hospital mortality. Any history of vascular disease was present in 5915 (8.6%) of the population, of whom 4840 (82%) had CAD and 1 other disease location and 1075 (18%) had CAD and 2 or 3 other disease locations. There was a significant relationship between the number of disease locations and hospital mortality, ranging from 0.7% in patients with CAD alone to 2.0% and 2.6% for patients with 1 or >or =2 disease locations, respectively (P<0.001). In unadjusted analysis, in-hospital mortality was approximately 3-fold higher (odds ratio, 2.89; 95% CI, 2.31 to 3.60; P<0.001) and 4-fold higher (odds ratio, 3.78; 95% CI, 2.57 to 5.56; P<0.001) for inpatients with CAD and additional vascular disease at 1 site and > or =2 sites, respectively. After multivariable adjustment, each additional vascular bed affected was associated with a 50% increase in in-hospital mortality (odds ratio, 1.50; 95% CI, 1.27 to 1.78; P<0.001).
Among patients with CAD undergoing percutaneous coronary intervention, vascular disease burden is associated with higher rates of adverse events and is an independent predictor of in-hospital mortality.</description><subject>Aged</subject><subject>Angioplasty, Balloon, Coronary - adverse effects</subject><subject>Angioplasty, Balloon, Coronary - mortality</subject><subject>Atherosclerosis - complications</subject><subject>Atherosclerosis - mortality</subject><subject>Coronary Artery Disease - complications</subject><subject>Coronary Artery Disease - mortality</subject><subject>Coronary Artery Disease - therapy</subject><subject>Female</subject><subject>Heart Diseases - etiology</subject><subject>Heart Diseases - mortality</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>New York</subject><subject>Odds Ratio</subject><subject>Peripheral Vascular Diseases - complications</subject><subject>Peripheral Vascular Diseases - mortality</subject><subject>Registries</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>1941-7640</issn><issn>1941-7632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplUctOwzAQtBCI9y8g3zil2M7D8RFVpVSqWqmUSpwiJ95AILGD7YA48esYtSAkTju7O5p9DEJXlIwozejVeLYazxbryWozWaxny8XdiJJ8lCc8ScUfuIeOqUhoxLOY7f_ihByhE-eeCQnljB2iI0ZITHmcHKPPjXTV0EqLVeNAOsDlYBVoLLXCjY6ejOsbL1tsBl-ZDhyWndGPuJe-Ae0dHrQC-2ia7xrYavBSgxkcrow1WtqPIOLBvgVuY3RI8ALe8YOxL_jOSw9n6KCWrYPzXTxF9zeT9fg2mi-ns_H1PKpSInwkJCeQ5apkhJairmXKFEiIk3BpWqqapknFSoCS16zmMhOKZCCIYHnOmSBpfIout7q9Na8DOF90jaugbbfrFjyOM8IzkgTmdMusrHHOQl30tunCJQUlxbcZxT8zQicvtg78gUHpYjdzKDtQvzo_34-_AFs-jS8</recordid><startdate>20090801</startdate><enddate>20090801</enddate><creator>Berger, Jeffrey S</creator><creator>Petersen, John L</creator><creator>Brown, David L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090801</creationdate><title>Vascular disease burden and in-hospital outcomes among patients undergoing percutaneous coronary intervention in New York State</title><author>Berger, Jeffrey S ; Petersen, John L ; Brown, David L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-9a70e68db201b9ffa52deae347635bdf154c2beeb7f2f7a69d06e909288729053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Angioplasty, Balloon, Coronary - adverse effects</topic><topic>Angioplasty, Balloon, Coronary - mortality</topic><topic>Atherosclerosis - complications</topic><topic>Atherosclerosis - mortality</topic><topic>Coronary Artery Disease - complications</topic><topic>Coronary Artery Disease - mortality</topic><topic>Coronary Artery Disease - therapy</topic><topic>Female</topic><topic>Heart Diseases - etiology</topic><topic>Heart Diseases - mortality</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>New York</topic><topic>Odds Ratio</topic><topic>Peripheral Vascular Diseases - complications</topic><topic>Peripheral Vascular Diseases - mortality</topic><topic>Registries</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berger, Jeffrey S</creatorcontrib><creatorcontrib>Petersen, John L</creatorcontrib><creatorcontrib>Brown, David L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation. Cardiovascular interventions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berger, Jeffrey S</au><au>Petersen, John L</au><au>Brown, David L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vascular disease burden and in-hospital outcomes among patients undergoing percutaneous coronary intervention in New York State</atitle><jtitle>Circulation. Cardiovascular interventions</jtitle><addtitle>Circ Cardiovasc Interv</addtitle><date>2009-08-01</date><risdate>2009</risdate><volume>2</volume><issue>4</issue><spage>317</spage><epage>322</epage><pages>317-322</pages><issn>1941-7640</issn><eissn>1941-7632</eissn><abstract>The presence of atherosclerosis in extracardiac vascular beds is associated with an increased risk of adverse cardiovascular outcomes among stable patients with coronary artery disease (CAD). However, there is little data regarding the impact of the presence and extent of vascular disease on outcomes in patients with CAD undergoing percutaneous coronary intervention.
We analyzed 69,045 consecutive patients from the New York State Coronary Angioplasty Reporting System database who underwent percutaneous coronary intervention between 1998 and 1999. Vascular disease burden was assessed by history of aortoiliac, femoral-popliteal, and carotid disease. Patients were stratified into 3 groups: CAD alone, CAD and 1 additional site, and CAD and 2 or 3 additional sites. A logistic regression model was constructed to determine the relation between vascular disease burden and in-hospital mortality. Any history of vascular disease was present in 5915 (8.6%) of the population, of whom 4840 (82%) had CAD and 1 other disease location and 1075 (18%) had CAD and 2 or 3 other disease locations. There was a significant relationship between the number of disease locations and hospital mortality, ranging from 0.7% in patients with CAD alone to 2.0% and 2.6% for patients with 1 or >or =2 disease locations, respectively (P<0.001). In unadjusted analysis, in-hospital mortality was approximately 3-fold higher (odds ratio, 2.89; 95% CI, 2.31 to 3.60; P<0.001) and 4-fold higher (odds ratio, 3.78; 95% CI, 2.57 to 5.56; P<0.001) for inpatients with CAD and additional vascular disease at 1 site and > or =2 sites, respectively. After multivariable adjustment, each additional vascular bed affected was associated with a 50% increase in in-hospital mortality (odds ratio, 1.50; 95% CI, 1.27 to 1.78; P<0.001).
Among patients with CAD undergoing percutaneous coronary intervention, vascular disease burden is associated with higher rates of adverse events and is an independent predictor of in-hospital mortality.</abstract><cop>United States</cop><pmid>20031734</pmid><doi>10.1161/CIRCINTERVENTIONS.108.847459.108.847459</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Heart Association Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Aged Angioplasty, Balloon, Coronary - adverse effects Angioplasty, Balloon, Coronary - mortality Atherosclerosis - complications Atherosclerosis - mortality Coronary Artery Disease - complications Coronary Artery Disease - mortality Coronary Artery Disease - therapy Female Heart Diseases - etiology Heart Diseases - mortality Hospital Mortality Humans Logistic Models Male Middle Aged New York Odds Ratio Peripheral Vascular Diseases - complications Peripheral Vascular Diseases - mortality Registries Retrospective Studies Risk Assessment Risk Factors Time Factors Treatment Outcome |
| title | Vascular disease burden and in-hospital outcomes among patients undergoing percutaneous coronary intervention in New York State |
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