Rho/ROCK and MEK/ERK activation by transforming growth factor-α induces articular cartilage degradation

Identification and characterization of therapeutic targets for joint conditions, such as osteoarthritis (OA), is exceedingly important for addressing the increasing burden of disease. Transforming growth factor-α (TGFα) is upregulated by articular chondrocytes in experimentally induced and human OA....

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Veröffentlicht in:	Laboratory investigation 2010-01, Vol.90 (1), p.20-30
Hauptverfasser:	Appleton, C Thomas G, Usmani, Shirine E, Mort, John S, Beier, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggrecans - metabolism Animals articular cartilage Biological and medical sciences Biotechnology Bone and Bones - metabolism Cartilage, Articular - metabolism Cartilage, Articular - pathology Cell Proliferation - drug effects Cells, Cultured chondrocyte Chondrocytes - metabolism Collagen Type II - metabolism Diseases of the osteoarticular system Enzyme Activation epidermal growth factor receptor Extracellular Matrix - drug effects Extracellular Matrix - genetics Fundamental and applied biological sciences. Psychology Gene Expression Regulation Humans Intracellular Membranes - metabolism Investigative techniques, diagnostic techniques (general aspects) Laboratory Medicine Male Medical sciences Medicine Medicine & Public Health Metabolism - genetics Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinase Kinases - metabolism Osteoarthritis Pathology Rats Rats, Sprague-Dawley Recombinant Proteins - pharmacology research-article rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - metabolism rhoA GTP-Binding Protein - antagonists & inhibitors rhoA GTP-Binding Protein - metabolism Signal Transduction - drug effects transforming growth factor alpha Transforming Growth Factor alpha - pharmacology
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