Salmonella typhimurium Strains Carrying Independent Mutations Display Similar Virulence Phenotypes Yet Are Controlled by Distinct Host Defense Mechanisms

The outcome of Salmonella infection in the mammalian host favors whoever succeeds best in disturbing the equilibrium between coordinate expression of bacterial (virulence) genes and host defense mechanisms. Intracellular persistence in host cells is critical for pathogenesis and disease, because Sal...

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Veröffentlicht in:	The Journal of immunology (1950) 2003-06, Vol.170 (12), p.6133-6140
Hauptverfasser:	Raupach, Barbel, Kurth, Nicole, Pfeffer, Klaus, Kaufmann, Stefan H. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antigens, CD - genetics Antigens, CD - physiology Immunity, Innate - genetics Immunocompromised Host - genetics Interferon-gamma - physiology Intracellular Fluid - immunology Intracellular Fluid - microbiology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Mutation Phenotype Plasmids Receptors, Antigen, T-Cell, alpha-beta - physiology Receptors, Tumor Necrosis Factor - deficiency Receptors, Tumor Necrosis Factor - genetics Receptors, Tumor Necrosis Factor - physiology Receptors, Tumor Necrosis Factor, Type I Salmonella Infections, Animal - genetics Salmonella Infections, Animal - immunology Salmonella Infections, Animal - microbiology Salmonella typhimurium - genetics Salmonella typhimurium - growth & development Salmonella typhimurium - immunology Salmonella typhimurium - pathogenicity Signal Transduction - genetics Signal Transduction - immunology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - microbiology Tumor Necrosis Factor-alpha - physiology Virulence
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