Cytogenetics of neurofibromas: two case reports and literature review

Cytogenetics of neurofibromas: two case reports and literature review

Abstract Only a few karyotypes of neurofibromas have been documented in the literature. In this report, we describe two new cases in which conventional cytogenetics demonstrated the presence of abnormal clones. Combining karyotypes of the nine previously reported cases, we found that the most freque...

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Veröffentlicht in:Cancer genetics and cytogenetics 2010, Vol.196 (1), p.93-95
Hauptverfasser: Liu, Kenian, DeAngelo, Patricia, Mahmet, Kathleen, Phytides, Penny, Osborne, Lisa, Pletcher, Beth A
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Female
Hematology, Oncology and Palliative Medicine
Humans
Karyotyping
Male
Medical Education
Neurofibroma - genetics
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Zusammenfassung:Abstract Only a few karyotypes of neurofibromas have been documented in the literature. In this report, we describe two new cases in which conventional cytogenetics demonstrated the presence of abnormal clones. Combining karyotypes of the nine previously reported cases, we found that the most frequent structural rearrangements involved chromosome 9p. Including the two cases reported here, 5/11 cases involved 9p, and four of these involved the 9p21∼p22 region.
ISSN:0165-4608
1873-4456
DOI:10.1016/j.cancergencyto.2009.07.004