Thromboangiitis obliterans with multiple large vessel involvement: case report and analysis of immunophenotypes
Abstract Thromboangiitis obliterans (TAO, Buerger's disease) is an idiopathic, recurrent, segmental, nonatherosclerotic, inflammatory, occlusive vascular disease with a poorly understood pathogenesis. Intestinal or multi-organ involvement is rare. Recent immunohistochemical analyses of ordinary...
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| Veröffentlicht in: | Cardiovascular pathology 2010, Vol.19 (1), p.59-62 |
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| container_title | Cardiovascular pathology |
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| creator | Edo, Naoki Miyai, Kosuke Ogata, Sho Nakanishi, Kuniaki Hiroi, Sadayuki Tominaga, Susumu Aiko, Satoshi Kawai, Toshiaki |
| description | Abstract Thromboangiitis obliterans (TAO, Buerger's disease) is an idiopathic, recurrent, segmental, nonatherosclerotic, inflammatory, occlusive vascular disease with a poorly understood pathogenesis. Intestinal or multi-organ involvement is rare. Recent immunohistochemical analyses of ordinary TAO have indicated an inflammatory and immunologic pathogenesis. We report a case of TAO involving multiple large vessels. By immunohistochemistry, CD3(+) T cells were revealed around the recanalization sites within the abdominal aorta. CD4(+) T cells were almost equal in number to CD8(+) T cells. These findings indicate the participation of inflammatory and immunologic processes in TAO with multi-organ involvement (as in ordinary TAO). |
| doi_str_mv | 10.1016/j.carpath.2008.10.004 |
| format | Article |
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Intestinal or multi-organ involvement is rare. Recent immunohistochemical analyses of ordinary TAO have indicated an inflammatory and immunologic pathogenesis. We report a case of TAO involving multiple large vessels. By immunohistochemistry, CD3(+) T cells were revealed around the recanalization sites within the abdominal aorta. CD4(+) T cells were almost equal in number to CD8(+) T cells. These findings indicate the participation of inflammatory and immunologic processes in TAO with multi-organ involvement (as in ordinary TAO).</description><identifier>ISSN: 1054-8807</identifier><identifier>EISSN: 1879-1336</identifier><identifier>DOI: 10.1016/j.carpath.2008.10.004</identifier><identifier>PMID: 19135391</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Fatal Outcome ; Humans ; Immunohistochemistry ; Immunophenotype ; Immunophenotyping ; Intestinal Buerger's disease ; Male ; Middle Aged ; Pathology ; Smoking ; T-Lymphocyte Subsets - immunology ; Thromboangiitis obliterans ; Thromboangiitis Obliterans - immunology ; Thromboangiitis Obliterans - pathology ; Thromboangiitis Obliterans - physiopathology</subject><ispartof>Cardiovascular pathology, 2010, Vol.19 (1), p.59-62</ispartof><rights>Elsevier Inc.</rights><rights>2010 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-cd7d2cae3b973a97591964a187eb49a0d4a174465883ee972c46cd2b65767493</citedby><cites>FETCH-LOGICAL-c419t-cd7d2cae3b973a97591964a187eb49a0d4a174465883ee972c46cd2b65767493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.carpath.2008.10.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19135391$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Edo, Naoki</creatorcontrib><creatorcontrib>Miyai, Kosuke</creatorcontrib><creatorcontrib>Ogata, Sho</creatorcontrib><creatorcontrib>Nakanishi, Kuniaki</creatorcontrib><creatorcontrib>Hiroi, Sadayuki</creatorcontrib><creatorcontrib>Tominaga, Susumu</creatorcontrib><creatorcontrib>Aiko, Satoshi</creatorcontrib><creatorcontrib>Kawai, Toshiaki</creatorcontrib><title>Thromboangiitis obliterans with multiple large vessel involvement: case report and analysis of immunophenotypes</title><title>Cardiovascular pathology</title><addtitle>Cardiovasc Pathol</addtitle><description>Abstract Thromboangiitis obliterans (TAO, Buerger's disease) is an idiopathic, recurrent, segmental, nonatherosclerotic, inflammatory, occlusive vascular disease with a poorly understood pathogenesis. 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These findings indicate the participation of inflammatory and immunologic processes in TAO with multi-organ involvement (as in ordinary TAO).</description><subject>Fatal Outcome</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Immunophenotype</subject><subject>Immunophenotyping</subject><subject>Intestinal Buerger's disease</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pathology</subject><subject>Smoking</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>Thromboangiitis obliterans</subject><subject>Thromboangiitis Obliterans - immunology</subject><subject>Thromboangiitis Obliterans - pathology</subject><subject>Thromboangiitis Obliterans - physiopathology</subject><issn>1054-8807</issn><issn>1879-1336</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcGO1DAMhisEYpeFRwDlxqlD0qRNwwG0WsEu0kocmHuUpp6dDGlS4nTQvD2pZiQkLhwsW9bv3_LnqnrL6IZR1n04bKxJs8n7TUNpX3obSsWz6pr1UtWM8-55qWkr6r6n8qp6hXigRSiEeFldMcV4yxW7ruJ2n-I0RBOenMsOSRy8y5BMQPLb5T2ZFp_d7IF4k56AHAERPHHhGP0RJgj5I7EGgSSYY8rEhLGE8SdcvXbETdMS4ryHEPNpBnxdvdgZj_Dmkm-q7dcv27uH-vH7_be728faCqZybUc5NtYAH5TkRslWMdUJU46DQShDx1JLIbq27zmAko0VnR2boWtlJ4XiN9X7s-2c4q8FMOvJoQXvTYC4oJYFEOWUsaJsz0qbImKCnZ6Tm0w6aUb1Slof9IW0Xkmv7UK6zL27bFiGCca_Uxe0RfD5LIBy5tFB0mgdBAujS2CzHqP774pP_zhY74Kzxv-EE-AhLqmQRs00NprqH-u712_TnlLGRc__AHRkqT0</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Edo, Naoki</creator><creator>Miyai, Kosuke</creator><creator>Ogata, Sho</creator><creator>Nakanishi, Kuniaki</creator><creator>Hiroi, Sadayuki</creator><creator>Tominaga, Susumu</creator><creator>Aiko, Satoshi</creator><creator>Kawai, Toshiaki</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2010</creationdate><title>Thromboangiitis obliterans with multiple large vessel involvement: case report and analysis of immunophenotypes</title><author>Edo, Naoki ; Miyai, Kosuke ; Ogata, Sho ; Nakanishi, Kuniaki ; Hiroi, Sadayuki ; Tominaga, Susumu ; Aiko, Satoshi ; Kawai, Toshiaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-cd7d2cae3b973a97591964a187eb49a0d4a174465883ee972c46cd2b65767493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Fatal Outcome</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Immunophenotype</topic><topic>Immunophenotyping</topic><topic>Intestinal Buerger's disease</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pathology</topic><topic>Smoking</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>Thromboangiitis obliterans</topic><topic>Thromboangiitis Obliterans - immunology</topic><topic>Thromboangiitis Obliterans - pathology</topic><topic>Thromboangiitis Obliterans - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Edo, Naoki</creatorcontrib><creatorcontrib>Miyai, Kosuke</creatorcontrib><creatorcontrib>Ogata, Sho</creatorcontrib><creatorcontrib>Nakanishi, Kuniaki</creatorcontrib><creatorcontrib>Hiroi, Sadayuki</creatorcontrib><creatorcontrib>Tominaga, Susumu</creatorcontrib><creatorcontrib>Aiko, Satoshi</creatorcontrib><creatorcontrib>Kawai, Toshiaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiovascular pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Edo, Naoki</au><au>Miyai, Kosuke</au><au>Ogata, Sho</au><au>Nakanishi, Kuniaki</au><au>Hiroi, Sadayuki</au><au>Tominaga, Susumu</au><au>Aiko, Satoshi</au><au>Kawai, Toshiaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thromboangiitis obliterans with multiple large vessel involvement: case report and analysis of immunophenotypes</atitle><jtitle>Cardiovascular pathology</jtitle><addtitle>Cardiovasc Pathol</addtitle><date>2010</date><risdate>2010</risdate><volume>19</volume><issue>1</issue><spage>59</spage><epage>62</epage><pages>59-62</pages><issn>1054-8807</issn><eissn>1879-1336</eissn><abstract>Abstract Thromboangiitis obliterans (TAO, Buerger's disease) is an idiopathic, recurrent, segmental, nonatherosclerotic, inflammatory, occlusive vascular disease with a poorly understood pathogenesis. Intestinal or multi-organ involvement is rare. Recent immunohistochemical analyses of ordinary TAO have indicated an inflammatory and immunologic pathogenesis. We report a case of TAO involving multiple large vessels. By immunohistochemistry, CD3(+) T cells were revealed around the recanalization sites within the abdominal aorta. CD4(+) T cells were almost equal in number to CD8(+) T cells. These findings indicate the participation of inflammatory and immunologic processes in TAO with multi-organ involvement (as in ordinary TAO).</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>19135391</pmid><doi>10.1016/j.carpath.2008.10.004</doi><tpages>4</tpages></addata></record> |
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| ispartof | Cardiovascular pathology, 2010, Vol.19 (1), p.59-62 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Fatal Outcome Humans Immunohistochemistry Immunophenotype Immunophenotyping Intestinal Buerger's disease Male Middle Aged Pathology Smoking T-Lymphocyte Subsets - immunology Thromboangiitis obliterans Thromboangiitis Obliterans - immunology Thromboangiitis Obliterans - pathology Thromboangiitis Obliterans - physiopathology |
| title | Thromboangiitis obliterans with multiple large vessel involvement: case report and analysis of immunophenotypes |
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