CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids

BACKGROUND: Disruption of the circadian system may be causal for manifestations of the metabolic syndrome (MetS). OBJECTIVE: The objective was to study the associations of 5 CLOCK polymorphisms with MetS features by analyzing fatty acid (FA) composition from dietary and red blood cell (RBC) membrane...

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Veröffentlicht in:	The American journal of clinical nutrition 2009-12, Vol.90 (6), p.1466-1475
Hauptverfasser:	Garaulet, Marta, Lee, Yu-Chi, Shen, Jian, Parnell, Laurence D, Arnett, Donna K, Tsai, Michael Y, Lai, Chao-Qiang, Ordovas, Jose M
Format:	Artikel
Sprache:	eng
Schlagworte:	administration & dosage Adult Aged analysis anthropometric measurements Biochemistry Biological and medical sciences Biological variation Body Mass Index cell membranes chemistry circadian rhythm CLOCK Proteins CLOCK Proteins - genetics Diet diet therapy diet-related diseases dietary nutrient sources Erythrocyte Membrane Erythrocyte Membrane - chemistry erythrocytes etiology Fatty acids Fatty Acids, Monounsaturated Fatty Acids, Monounsaturated - administration & dosage Fatty Acids, Monounsaturated - analysis Feeding. Feeding behavior Female food choices food intake functional foods Fundamental and applied biological sciences. Psychology genetic variation genetics Genetics of Lipid Lowering Drugs and Diet Network study Genotype Haplotypes Humans hypertension Insulin Resistance Lipids Male medicinal properties men Metabolic syndrome Metabolic Syndrome - etiology Metabolic Syndrome - genetics Middle Aged monounsaturated fatty acids neutrophils nutritive value Obesity and eating disorders Original Research Communications Polymorphism Polymorphism, Single Nucleotide postprandial state Risk risk factors Vertebrates: anatomy and physiology, studies on body, several organs or systems women
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