The effect of peripheral administration of growth hormone on AD-like cognitive deficiency in NBM-lesioned rats
This study aimed to evaluate the peripheral administration of growth hormone (GH) on AD-like cognitive deficiency in NBM-lesioned rats induced by ibotenic acid (5 μg/μl, in each side). Forty-eight male Wistar rats (20–24 months old; weighing 330 ± 30 g) randomly divided into six groups ( n = 8). The...
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| Veröffentlicht in: | Neuroscience letters 2009-11, Vol.466 (1), p.47-51 |
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| creator | Doulah, A.H. Rohani, A. Haeri Haddad, M. Khaksari Motamedi, F. Farbood, Y. Badavi, M. Malek, M. Sarkaki, A. |
| description | This study aimed to evaluate the peripheral administration of growth hormone (GH) on AD-like cognitive deficiency in NBM-lesioned rats induced by ibotenic acid (5
μg/μl, in each side). Forty-eight male Wistar rats (20–24 months old; weighing 330
±
30
g) randomly divided into six groups (
n
=
8). The groups include control group, which were intact rats; n-L
+
GH group: non-lesioned rats with GH treatment (1
mg/kg, 9.00
am, for 10 consecutive days); n-L
+
Veh group: non-lesioned rats with vehicle treatment; L group: NBM-lesioned rats; L
+
GH group: NBM-lesioned rats with GH treatment and L
+
Veh group: NBM-lesioned rats with same volume of vehicle treatment. Peripheral administration of GH in control had no effect on learning and memory, while in L
+
GH group produced a significant enhancement in spatial learning and memory comparing to L and L
+
Veh groups. The percent of time spent in goal quarter during probe trial has decreased significantly in L and L
+
Veh groups compared to n-L groups. While it has increased significantly in L
+
GH group compared to L and L
+
Veh groups. No significant difference in percent of time spent was seen between the control and n-L groups. The GH has known as a mediate that effect through IGF-1. As the IGF-1 itself is earlier shown to improve cognitive function it is likely that the observed effect of GH is mediated through release of IGF-1 from peripheral tissue into the circulation for further transport across the BBB. This mechanism may result in the improvement of learning and memory in rats with NBM lesion. |
| doi_str_mv | 10.1016/j.neulet.2009.09.016 |
| format | Article |
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μg/μl, in each side). Forty-eight male Wistar rats (20–24 months old; weighing 330
±
30
g) randomly divided into six groups (
n
=
8). The groups include control group, which were intact rats; n-L
+
GH group: non-lesioned rats with GH treatment (1
mg/kg, 9.00
am, for 10 consecutive days); n-L
+
Veh group: non-lesioned rats with vehicle treatment; L group: NBM-lesioned rats; L
+
GH group: NBM-lesioned rats with GH treatment and L
+
Veh group: NBM-lesioned rats with same volume of vehicle treatment. Peripheral administration of GH in control had no effect on learning and memory, while in L
+
GH group produced a significant enhancement in spatial learning and memory comparing to L and L
+
Veh groups. The percent of time spent in goal quarter during probe trial has decreased significantly in L and L
+
Veh groups compared to n-L groups. While it has increased significantly in L
+
GH group compared to L and L
+
Veh groups. No significant difference in percent of time spent was seen between the control and n-L groups. The GH has known as a mediate that effect through IGF-1. As the IGF-1 itself is earlier shown to improve cognitive function it is likely that the observed effect of GH is mediated through release of IGF-1 from peripheral tissue into the circulation for further transport across the BBB. This mechanism may result in the improvement of learning and memory in rats with NBM lesion.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2009.09.016</identifier><identifier>PMID: 19765635</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Alzheimer Disease - drug therapy ; Alzheimer Disease - pathology ; Alzheimer Disease - psychology ; Animals ; Basal Nucleus of Meynert - pathology ; Biological and medical sciences ; Cognition Disorders - drug therapy ; Cognition Disorders - pathology ; Cognition Disorders - psychology ; Disease Models, Animal ; Fundamental and applied biological sciences. Psychology ; Growth hormone ; Growth Hormone - administration & dosage ; Growth Hormone - therapeutic use ; Ibotenic acid ; Injections, Subcutaneous ; Learning - drug effects ; Male ; Maze Learning - drug effects ; Memory - drug effects ; Morris water maze ; NBM ; Rats ; Rats, Wistar ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 2009-11, Vol.466 (1), p.47-51</ispartof><rights>2009 Elsevier Ireland Ltd</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-ae05743765a72ff40d7a051598f88be9a2e9d100410bb491c85f62954254ca813</citedby><cites>FETCH-LOGICAL-c422t-ae05743765a72ff40d7a051598f88be9a2e9d100410bb491c85f62954254ca813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neulet.2009.09.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22075691$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19765635$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Doulah, A.H.</creatorcontrib><creatorcontrib>Rohani, A. Haeri</creatorcontrib><creatorcontrib>Haddad, M. Khaksari</creatorcontrib><creatorcontrib>Motamedi, F.</creatorcontrib><creatorcontrib>Farbood, Y.</creatorcontrib><creatorcontrib>Badavi, M.</creatorcontrib><creatorcontrib>Malek, M.</creatorcontrib><creatorcontrib>Sarkaki, A.</creatorcontrib><title>The effect of peripheral administration of growth hormone on AD-like cognitive deficiency in NBM-lesioned rats</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>This study aimed to evaluate the peripheral administration of growth hormone (GH) on AD-like cognitive deficiency in NBM-lesioned rats induced by ibotenic acid (5
μg/μl, in each side). Forty-eight male Wistar rats (20–24 months old; weighing 330
±
30
g) randomly divided into six groups (
n
=
8). The groups include control group, which were intact rats; n-L
+
GH group: non-lesioned rats with GH treatment (1
mg/kg, 9.00
am, for 10 consecutive days); n-L
+
Veh group: non-lesioned rats with vehicle treatment; L group: NBM-lesioned rats; L
+
GH group: NBM-lesioned rats with GH treatment and L
+
Veh group: NBM-lesioned rats with same volume of vehicle treatment. Peripheral administration of GH in control had no effect on learning and memory, while in L
+
GH group produced a significant enhancement in spatial learning and memory comparing to L and L
+
Veh groups. The percent of time spent in goal quarter during probe trial has decreased significantly in L and L
+
Veh groups compared to n-L groups. While it has increased significantly in L
+
GH group compared to L and L
+
Veh groups. No significant difference in percent of time spent was seen between the control and n-L groups. The GH has known as a mediate that effect through IGF-1. As the IGF-1 itself is earlier shown to improve cognitive function it is likely that the observed effect of GH is mediated through release of IGF-1 from peripheral tissue into the circulation for further transport across the BBB. This mechanism may result in the improvement of learning and memory in rats with NBM lesion.</description><subject>Alzheimer Disease - drug therapy</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer Disease - psychology</subject><subject>Animals</subject><subject>Basal Nucleus of Meynert - pathology</subject><subject>Biological and medical sciences</subject><subject>Cognition Disorders - drug therapy</subject><subject>Cognition Disorders - pathology</subject><subject>Cognition Disorders - psychology</subject><subject>Disease Models, Animal</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Growth hormone</subject><subject>Growth Hormone - administration & dosage</subject><subject>Growth Hormone - therapeutic use</subject><subject>Ibotenic acid</subject><subject>Injections, Subcutaneous</subject><subject>Learning - drug effects</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Memory - drug effects</subject><subject>Morris water maze</subject><subject>NBM</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9v1DAQxS0EotuFb4CQL7SnbMeOncQXpNLyp1KBSzlbXmfc9ZLYi50t6rfHYVdwqzTSSPZvnt7MI-QNgxUD1lxsVwH3A04rDqBWc7HmGVmwruVVq1r-nCygBlHVSsAJOc15CwCSSfGSnDDVNrKp5YKEuw1SdA7tRKOjO0x-t8FkBmr60Qefp2QmH8P8eZ_i72lDNzGNMSAtj5fX1eB_IrXxPvjJPyDt0XnrMdhH6gP99uFrNWAu89jTIpRfkRfODBlfH_uS_Pj08e7qS3X7_fPN1eVtZQXnU2UQZCvqYtK03DkBfWtm76pzXbdGZTiqngEIBuu1UMx20jVcScGlsKZj9ZKcH3R3Kf7aY5706LPFYTAB4z7rtq4bYKK0JTl7kuQMil4HBRQH0KaYc0Knd8mPJj1qBnpORG_1IRE9J6LnYk0Ze3vU369H7P8PHSMowLsjYLI1g0smWJ__cZxDKxs1r_T-wGG524PHpPPfQ2PvU0lP99E_7eQP346rEw</recordid><startdate>20091127</startdate><enddate>20091127</enddate><creator>Doulah, A.H.</creator><creator>Rohani, A. Haeri</creator><creator>Haddad, M. Khaksari</creator><creator>Motamedi, F.</creator><creator>Farbood, Y.</creator><creator>Badavi, M.</creator><creator>Malek, M.</creator><creator>Sarkaki, A.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20091127</creationdate><title>The effect of peripheral administration of growth hormone on AD-like cognitive deficiency in NBM-lesioned rats</title><author>Doulah, A.H. ; Rohani, A. Haeri ; Haddad, M. Khaksari ; Motamedi, F. ; Farbood, Y. ; Badavi, M. ; Malek, M. ; Sarkaki, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-ae05743765a72ff40d7a051598f88be9a2e9d100410bb491c85f62954254ca813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Alzheimer Disease - drug therapy</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer Disease - psychology</topic><topic>Animals</topic><topic>Basal Nucleus of Meynert - pathology</topic><topic>Biological and medical sciences</topic><topic>Cognition Disorders - drug therapy</topic><topic>Cognition Disorders - pathology</topic><topic>Cognition Disorders - psychology</topic><topic>Disease Models, Animal</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Growth hormone</topic><topic>Growth Hormone - administration & dosage</topic><topic>Growth Hormone - therapeutic use</topic><topic>Ibotenic acid</topic><topic>Injections, Subcutaneous</topic><topic>Learning - drug effects</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>Memory - drug effects</topic><topic>Morris water maze</topic><topic>NBM</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Doulah, A.H.</creatorcontrib><creatorcontrib>Rohani, A. Haeri</creatorcontrib><creatorcontrib>Haddad, M. Khaksari</creatorcontrib><creatorcontrib>Motamedi, F.</creatorcontrib><creatorcontrib>Farbood, Y.</creatorcontrib><creatorcontrib>Badavi, M.</creatorcontrib><creatorcontrib>Malek, M.</creatorcontrib><creatorcontrib>Sarkaki, A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Doulah, A.H.</au><au>Rohani, A. Haeri</au><au>Haddad, M. Khaksari</au><au>Motamedi, F.</au><au>Farbood, Y.</au><au>Badavi, M.</au><au>Malek, M.</au><au>Sarkaki, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of peripheral administration of growth hormone on AD-like cognitive deficiency in NBM-lesioned rats</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2009-11-27</date><risdate>2009</risdate><volume>466</volume><issue>1</issue><spage>47</spage><epage>51</epage><pages>47-51</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>This study aimed to evaluate the peripheral administration of growth hormone (GH) on AD-like cognitive deficiency in NBM-lesioned rats induced by ibotenic acid (5
μg/μl, in each side). Forty-eight male Wistar rats (20–24 months old; weighing 330
±
30
g) randomly divided into six groups (
n
=
8). The groups include control group, which were intact rats; n-L
+
GH group: non-lesioned rats with GH treatment (1
mg/kg, 9.00
am, for 10 consecutive days); n-L
+
Veh group: non-lesioned rats with vehicle treatment; L group: NBM-lesioned rats; L
+
GH group: NBM-lesioned rats with GH treatment and L
+
Veh group: NBM-lesioned rats with same volume of vehicle treatment. Peripheral administration of GH in control had no effect on learning and memory, while in L
+
GH group produced a significant enhancement in spatial learning and memory comparing to L and L
+
Veh groups. The percent of time spent in goal quarter during probe trial has decreased significantly in L and L
+
Veh groups compared to n-L groups. While it has increased significantly in L
+
GH group compared to L and L
+
Veh groups. No significant difference in percent of time spent was seen between the control and n-L groups. The GH has known as a mediate that effect through IGF-1. As the IGF-1 itself is earlier shown to improve cognitive function it is likely that the observed effect of GH is mediated through release of IGF-1 from peripheral tissue into the circulation for further transport across the BBB. This mechanism may result in the improvement of learning and memory in rats with NBM lesion.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>19765635</pmid><doi>10.1016/j.neulet.2009.09.016</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Neuroscience letters, 2009-11, Vol.466 (1), p.47-51 |
| issn | 0304-3940 1872-7972 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733601473 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alzheimer Disease - drug therapy Alzheimer Disease - pathology Alzheimer Disease - psychology Animals Basal Nucleus of Meynert - pathology Biological and medical sciences Cognition Disorders - drug therapy Cognition Disorders - pathology Cognition Disorders - psychology Disease Models, Animal Fundamental and applied biological sciences. Psychology Growth hormone Growth Hormone - administration & dosage Growth Hormone - therapeutic use Ibotenic acid Injections, Subcutaneous Learning - drug effects Male Maze Learning - drug effects Memory - drug effects Morris water maze NBM Rats Rats, Wistar Vertebrates: nervous system and sense organs |
| title | The effect of peripheral administration of growth hormone on AD-like cognitive deficiency in NBM-lesioned rats |
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