Structural and biophysical determinants of single Ca(V)3.1 and Ca(V)3.2 T-type calcium channel inhibition by N(2)O

We investigated the biophysical mechanism of inhibition of recombinant T-type calcium channels Ca(V)3.1 and Ca(V)3.2 by nitrous oxide (N(2)O). To identify functionally important channel structures, chimeras with reciprocal exchange of the N-terminal domains I and II and C-terminal domains III and IV...

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Veröffentlicht in:	Cell calcium (Edinburgh) 2009-10, Vol.46 (4), p.293-302
Hauptverfasser:	Bartels, Peter, Behnke, Kerstin, Michels, Guido, Groner, Ferdi, Schneider, Toni, Henry, Margit, Barrett, Paula Q, Kang, Ho-Won, Lee, Jung-Ha, Wiesen, Martin H J, Matthes, Jan, Herzig, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium Channels, T-Type - chemistry Calcium Channels, T-Type - drug effects Calcium Channels, T-Type - genetics Calcium Channels, T-Type - metabolism Cell Line, Transformed Electrophysiology - methods Humans Ion Channel Gating - genetics Ion Channel Gating - physiology Nitrous Oxide - metabolism Nitrous Oxide - pharmacology Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - drug effects Recombinant Fusion Proteins - metabolism
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