Genistein induces G2/M cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways

Genistein is a major isoflavonoid in dietary soybean, commonly consumed in Asia. Genistein exerts inhibitory effects on the proliferation of various cancer cells and plays an important role in cancer prevention. However, the molecular and cellular mechanisms of genistein on human ovarian cancer cell...

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Veröffentlicht in:	Cell biology international 2009-12, Vol.33 (12), p.1237-1244
Hauptverfasser:	Ouyang, Gaoliang, Yao, Luming, Ruan, Kai, Song, Gang, Mao, Yubin, Bao, Shideng
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticarcinogenic Agents - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - genetics Ataxia Telangiectasia Mutated Proteins bcl-2-Associated X Protein - metabolism bcl-X Protein - metabolism BRCA1 Protein - metabolism CDC2 Protein Kinase cdc25 Phosphatases - metabolism Cell Cycle - drug effects Cell Cycle - genetics Cell Cycle Proteins - metabolism Cell Line, Tumor Cell Proliferation - drug effects Checkpoint Kinase 1 Checkpoint Kinase 2 Cyclin B - metabolism Cyclin-Dependent Kinases DNA Damage - drug effects DNA damage checkpoint DNA-Binding Proteins - metabolism Female Genistein Genistein - pharmacology Humans Ovarian cancer cell Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Phosphorylation Protein Kinases - metabolism Protein-Serine-Threonine Kinases - metabolism Signal Transduction - drug effects Signal Transduction - genetics Tumor Suppressor Proteins - metabolism
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