Muscle-conditioned media and cAMP promote survival and neurite outgrowth of adult spinal cord motor neurons

Embryonic spinal cord motor neurons (MNs) can be maintained in vitro for weeks with a cocktail of trophic factors and muscle-derived factors under serum-containing conditions. Here we investigated the beneficial effects of muscle-derived factors in the form of muscle-conditioned medium (MCM) on the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Experimental neurology 2009-12, Vol.220 (2), p.303-315
Hauptverfasser:	Montoya G., Jose V., Sutachan, Jhon Jairo, Chan, Wai Si, Sideris, Alexandra, Blanck, Thomas J.J., Recio-Pinto, Esperanza
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Adult rat Animals BDNF Biological and medical sciences cAMP Cell Survival - drug effects Cells, Cultured Culture Media, Conditioned Culture Media, Serum-Free Cyclic AMP - pharmacology Electrophysiology GDNF Image Processing, Computer-Assisted Immunohistochemistry Injuries of the nervous system and the skull. Diseases due to physical agents Intercellular Signaling Peptides and Proteins - pharmacology MAP2 Medical sciences Motor neurons Motor Neurons - drug effects Muscle conditioned medium Muscle, Skeletal - physiology Neurites - drug effects Neurology Neurons - drug effects Rats Rats, Sprague-Dawley SMI32 Spinal cord Spinal Cord - cytology Spinal Cord - drug effects Traumas. Diseases due to physical agents Ventral horn
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!