Evaluation of the Potential for Drug-Induced Liver Injury Based on in Vitro Covalent Binding to Human Liver Proteins

Prediction of idiosyncratic drug-induced liver injury (DILI) is difficult, and the underlying mechanisms are not fully understood. However, many drugs causing DILI are considered to form reactive metabolites and covalently bind to cellular macromolecules in the liver. The objective of this study was...

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Veröffentlicht in:	Drug metabolism and disposition 2009-12, Vol.37 (12), p.2383-2392
Hauptverfasser:	Usui, Toru, Mise, Masashi, Hashizume, Takanori, Yabuki, Masashi, Komuro, Setsuko
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - metabolism Clinical trial. Drug monitoring Cytochrome P-450 Enzyme System - metabolism Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment General pharmacology Glucuronic Acid - metabolism Glucuronosyltransferase - metabolism Glutathione - metabolism Hepatocytes - drug effects Hepatocytes - metabolism Humans Liver - drug effects Liver - metabolism Medical sciences Metabolomics Microsomes, Liver - drug effects Microsomes, Liver - metabolism NADP - metabolism Pharmacology. Drug treatments Protein Binding Reproducibility of Results Risk Assessment Risk Factors Toxicity: digestive system
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