Neo-vascularization and bone formation mediated by fetal mesenchymal stem cell tissue-engineered bone grafts in critical-size femoral defects

Abstract Tissue-engineered bone grafts (TEBG) require highly osteogenic cell sources for use in fracture repair applications. Compared to other sources of mesenchymal stem cells (MSC), human fetal MSC (hfMSC) have recently been shown to be more proliferative and osteogenic. We studied the functional...

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Veröffentlicht in:	Biomaterials 2010-02, Vol.31 (4), p.608-620
Hauptverfasser:	Zhang, Zhi-Yong, Teoh, Swee-Hin, Chong, Mark S.K, Lee, Eddy S.M, Tan, Lay-Geok, Mattar, Citra N, Fisk, Nicholas M, Choolani, Mahesh, Chan, Jerry
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Bone tissue engineering Critical size defect Dentistry Femur - blood supply Fetal mesenchymal stem cells Fetus - cytology Humans Immunohistochemistry Male Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - physiology Microscopy, Atomic Force Neovascularization, Physiologic - physiology Osteogenesis - physiology Poly-caprolactone Random Allocation Rat femur Rats Rats, Sprague-Dawley Tissue Engineering - methods Tomography, X-Ray Computed
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