Comparison of Dual Source Computed Tomography Versus Intravascular Ultrasound for Evaluation of Coronary Arteries at Least One Year After Cardiac Transplantation
This study evaluated the ability of dual-source computed tomography (DSCT) to detect coronary allograft vasculopathy (CAV) in heart transplant recipients using intravascular ultrasound (IVUS) as the standard of reference. Thirty patients with heart transplants (81% men, mean age 40 years) underwent...
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| Veröffentlicht in: | The American journal of cardiology 2009-11, Vol.104 (10), p.1351-1356 |
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| creator | Schepis, Tiziano, MD Achenbach, Stephan, MD Weyand, Michael, MD Raum, Philip, MD Marwan, Mohamed, MD Pflederer, Tobias, MD Daniel, Werner G., MD Tandler, Rene, MD Kondruweit, Markus, MD Ropers, Dieter, MD |
| description | This study evaluated the ability of dual-source computed tomography (DSCT) to detect coronary allograft vasculopathy (CAV) in heart transplant recipients using intravascular ultrasound (IVUS) as the standard of reference. Thirty patients with heart transplants (81% men, mean age 40 years) underwent DSCT (330-ms gantry rotation, 2 × 64 × 0.6-mm collimation, 60- to 80-ml contrast agent, no additional β blockers) before invasive coronary angiography including IVUS of 1 vessel. Detection of CAV by DSCT was qualitatively defined as the presence of any coronary plaque. Mean heart rate during dual-source computed tomographic scanning was 80 ± 14 beats/min. Four hundred fifty-nine segments with a vessel caliber ≥1.5 mm according to quantitative coronary angiography were evaluated in 30 patients. Of these, 96% were considered to have excellent or good image quality. IVUS detected CAV in 17 of 30 patients (57%) and in 41 of 110 coronary segments (37%). Compared to IVUS, sensitivity, specificity, positive and negative predictive values for the detection of CAV by DSCT were 85%, 84%, 76%, and 91%, respectively. In conclusion, DSCT permits the investigation of transplant recipients concerning the presence of CAV with good image quality and high diagnostic accuracy. |
| doi_str_mv | 10.1016/j.amjcard.2009.06.060 |
| format | Article |
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Thirty patients with heart transplants (81% men, mean age 40 years) underwent DSCT (330-ms gantry rotation, 2 × 64 × 0.6-mm collimation, 60- to 80-ml contrast agent, no additional β blockers) before invasive coronary angiography including IVUS of 1 vessel. Detection of CAV by DSCT was qualitatively defined as the presence of any coronary plaque. Mean heart rate during dual-source computed tomographic scanning was 80 ± 14 beats/min. Four hundred fifty-nine segments with a vessel caliber ≥1.5 mm according to quantitative coronary angiography were evaluated in 30 patients. Of these, 96% were considered to have excellent or good image quality. IVUS detected CAV in 17 of 30 patients (57%) and in 41 of 110 coronary segments (37%). Compared to IVUS, sensitivity, specificity, positive and negative predictive values for the detection of CAV by DSCT were 85%, 84%, 76%, and 91%, respectively. In conclusion, DSCT permits the investigation of transplant recipients concerning the presence of CAV with good image quality and high diagnostic accuracy.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2009.06.060</identifier><identifier>PMID: 19892049</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Cardiology ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular disease ; Coronary Angiography - methods ; Coronary Artery Disease - diagnosis ; Coronary vessels ; Coronary Vessels - diagnostic imaging ; Female ; Heart Rate ; Heart Transplantation ; Humans ; Male ; Medical sciences ; Middle Aged ; Predictive Value of Tests ; Prospective Studies ; Sensitivity and Specificity ; Studies ; Tomography ; Tomography, X-Ray Computed - methods ; Transplants & implants ; Ultrasonic imaging ; Ultrasonography, Interventional ; Young Adult</subject><ispartof>The American journal of cardiology, 2009-11, Vol.104 (10), p.1351-1356</ispartof><rights>Elsevier Inc.</rights><rights>2009 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. 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Thirty patients with heart transplants (81% men, mean age 40 years) underwent DSCT (330-ms gantry rotation, 2 × 64 × 0.6-mm collimation, 60- to 80-ml contrast agent, no additional β blockers) before invasive coronary angiography including IVUS of 1 vessel. Detection of CAV by DSCT was qualitatively defined as the presence of any coronary plaque. Mean heart rate during dual-source computed tomographic scanning was 80 ± 14 beats/min. Four hundred fifty-nine segments with a vessel caliber ≥1.5 mm according to quantitative coronary angiography were evaluated in 30 patients. Of these, 96% were considered to have excellent or good image quality. IVUS detected CAV in 17 of 30 patients (57%) and in 41 of 110 coronary segments (37%). Compared to IVUS, sensitivity, specificity, positive and negative predictive values for the detection of CAV by DSCT were 85%, 84%, 76%, and 91%, respectively. 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Vascular system</topic><topic>Cardiovascular</topic><topic>Cardiovascular disease</topic><topic>Coronary Angiography - methods</topic><topic>Coronary Artery Disease - diagnosis</topic><topic>Coronary vessels</topic><topic>Coronary Vessels - diagnostic imaging</topic><topic>Female</topic><topic>Heart Rate</topic><topic>Heart Transplantation</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Studies</topic><topic>Tomography</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Transplants & implants</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography, Interventional</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schepis, Tiziano, MD</creatorcontrib><creatorcontrib>Achenbach, Stephan, MD</creatorcontrib><creatorcontrib>Weyand, Michael, MD</creatorcontrib><creatorcontrib>Raum, Philip, MD</creatorcontrib><creatorcontrib>Marwan, Mohamed, MD</creatorcontrib><creatorcontrib>Pflederer, Tobias, MD</creatorcontrib><creatorcontrib>Daniel, Werner G., MD</creatorcontrib><creatorcontrib>Tandler, Rene, MD</creatorcontrib><creatorcontrib>Kondruweit, Markus, MD</creatorcontrib><creatorcontrib>Ropers, Dieter, MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schepis, Tiziano, MD</au><au>Achenbach, Stephan, MD</au><au>Weyand, Michael, MD</au><au>Raum, Philip, MD</au><au>Marwan, Mohamed, MD</au><au>Pflederer, Tobias, MD</au><au>Daniel, Werner G., MD</au><au>Tandler, Rene, MD</au><au>Kondruweit, Markus, MD</au><au>Ropers, Dieter, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Dual Source Computed Tomography Versus Intravascular Ultrasound for Evaluation of Coronary Arteries at Least One Year After Cardiac Transplantation</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2009-11-15</date><risdate>2009</risdate><volume>104</volume><issue>10</issue><spage>1351</spage><epage>1356</epage><pages>1351-1356</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>This study evaluated the ability of dual-source computed tomography (DSCT) to detect coronary allograft vasculopathy (CAV) in heart transplant recipients using intravascular ultrasound (IVUS) as the standard of reference. Thirty patients with heart transplants (81% men, mean age 40 years) underwent DSCT (330-ms gantry rotation, 2 × 64 × 0.6-mm collimation, 60- to 80-ml contrast agent, no additional β blockers) before invasive coronary angiography including IVUS of 1 vessel. Detection of CAV by DSCT was qualitatively defined as the presence of any coronary plaque. Mean heart rate during dual-source computed tomographic scanning was 80 ± 14 beats/min. Four hundred fifty-nine segments with a vessel caliber ≥1.5 mm according to quantitative coronary angiography were evaluated in 30 patients. Of these, 96% were considered to have excellent or good image quality. IVUS detected CAV in 17 of 30 patients (57%) and in 41 of 110 coronary segments (37%). Compared to IVUS, sensitivity, specificity, positive and negative predictive values for the detection of CAV by DSCT were 85%, 84%, 76%, and 91%, respectively. In conclusion, DSCT permits the investigation of transplant recipients concerning the presence of CAV with good image quality and high diagnostic accuracy.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>19892049</pmid><doi>10.1016/j.amjcard.2009.06.060</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Biological and medical sciences Cardiology Cardiology. Vascular system Cardiovascular Cardiovascular disease Coronary Angiography - methods Coronary Artery Disease - diagnosis Coronary vessels Coronary Vessels - diagnostic imaging Female Heart Rate Heart Transplantation Humans Male Medical sciences Middle Aged Predictive Value of Tests Prospective Studies Sensitivity and Specificity Studies Tomography Tomography, X-Ray Computed - methods Transplants & implants Ultrasonic imaging Ultrasonography, Interventional Young Adult |
| title | Comparison of Dual Source Computed Tomography Versus Intravascular Ultrasound for Evaluation of Coronary Arteries at Least One Year After Cardiac Transplantation |
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